Antibiotics and pathogens

[Guest guest]

Hi and others,

wrt antibiotics and info – because such a wide subject, clarifying either the condition or pathogen will help greatly, eg the one I found below, as S aeruginosa is the main naughty bug I have, and is resistant to all oral abs except for Ciprofloxacin/Ciproxin (and other generic names)

http://prod.hopkins-abxguide.org/pathogens/bacteria/pseudomonas_aeruginosa.html?contentInstanceId=255806

Go to this page and select the particular pathogen.

http://prod.hopkins-abxguide.org/diagnosis/respiratory/bronchiectasis.html?contentInstanceId=255342

Something else to note: some abx are more prone to causing fungal infection (oral, lungs, skin etc etc, and can become VERY difficult to get under control – avoid if you can!)

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve & db=PubMed & dopt=AbstractPlus & list_uids=17443506

Below is an excerpt from an article “Prolonged antibiotics for purulent bronchiectasis in children and adults” on this website:

“ Response rates showed significant effects in favour of prolonged antibiotic treatment (Peto OR (95% CI), 3.37 (1.60 to 7.09)). Conversely for exacerbation rates there was no significant difference between prolonged antibiotics and placebo (Peto OR (95% CI), 0.96 (0.27 to 3.46)). For withdrawals there was no significant difference between treatment and placebo management (Peto OR (95% CI), 1.06 (0.42 to 2.65)). Data for lung function showed no significant benefit in favour of antibiotic treatment (% predicted FEV1 mean difference -1.05 % (95% CI -6.93 to 4.83)). AUTHORS' CONCLUSIONS: The evidence available shows a small benefit for the use of prolonged antibiotics in the treatment of bronchiectasis. [bold & itals mine] This review is limited by the diversity of the trials. Further randomised controlled trials with adequate power and standardised end points are required. “

(, just realised I hadn’t actually sent this, so hope it’s of use still),

cheers

Joy

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