Re: Pain In Fibromyalgia (and anxiety) Is Linked To Changes In Brain Mo...

[Guest guest]

To All,

Yes, when my PTSD was at its worse I had the flashbacks and the

nightmares. They are not as common anymore. I still have the

hypervigilence and do not like being startled. My dog is pretty good

at keeping me from that.....Also, just so you know alittle obsessive

compulsive behavior is common because serotonin is out of whack!

Incidentally, anxiety is very common with exposures. In addition, the

vanilloid receptor is implicated in MCS and so the health effects are

the same. Please remember that mold gives off MVOCs and your

olfactory receptors are picking it up even if you are not aware of

it.

The vanilloid receptors are located throughtout the body not just the

brain. " The sensitivity of this receptor to numerous physicochemical

factors (temperature, charge, acidity) and its widespread

distribution in the brain and other peripheral organ systems suggest

that the TRPV1 may be key to the inflammation associated with

environmental chemicals. Toxicologists have reported an initiating

role for TRPV1 in mediating airway inflammation (e.g.,

hyperresponsiveness, asthma) caused by chemical irritants and air

pollutants (e.g., particulate matter, ozone, pesticides (Veronesi et

al., 2001)). Identifying this receptor as a common responder to

multiple chemical toxicants could explain how diverse pollutants and

inhaled substances produce the respiratory dysfunction associated

with environmental contaminants. (1) In addition, high expression of

TRPV1 has been detected in several inflammatory diseases of the colon

and ileum, whereas neuropeptides released upon sensory nerve

stimulation triggered by TRPV1 activation seem to play a role in

intestinal motility disorders. TRPV1 antagonists, which will soon be

available for clinical testing, may undergo scrutiny for the

treatment of inflammatory diseases of the gut. (2)

Supplemental:

Symptoms of PTSD (3)

*Re-experiencing the traumatic event, through: unwanted, intrusive

memories dreams or nightmares, flashbacks

*Increased arousal, in the form of:

*Anxiety

*Difficulty sleeping

*Irritability

*Difficulty concentrating

*Being easily startled or angered

*Increased heart rate and breathing

*Nausea, diarrhea

Intense anxiety after experiencing sights, sounds, smells or events

that serve as reminders of the trauma and restimulate those

receptors, or on anniversaries of the trauma

*Avoidance of feeling or reminders, in the form of:

*Sadness, depression, feelings of numbness

*Avoiding everyday things that remind you of what happened

*Guilt, self-doubt, feelings of helplessness or hopelessness

*Loss of interest in activities.

http://www.heirs-online.com/TRPV1.html

Kim

Health Educator and Medical Researcher

Health Education Information and Resource Services

kkramer@...

1.The TRPV1 Receptor: Target of Toxicants and Therapeutics

Bellina Veronesi*,1 and Marga Oortgiesen. Toxicological Sciences 2006

89(1):1-3; doi:10.1093/toxsci/kfj034.

2. Activation and sensitisation of the vanilloid receptor: role in

gastrointestinal inflammation and function

Pierangelo Geppetti and Marcello Trevisani

Br J Pharmacol. 2004 April; 141(8): 1313–1320. Published online 2004

March 29. doi: 10.1038/sj.bjp.0705768.

3. Coping with Post-Traumatic Stress Disorder. What Every Woman

Should Know. National Women's Health Resource Center, November 2005.

http://www.healthywomen.org/ptsd/pg1.html

4. http://www.answers.com/topic/multiple-chemical-sensitivity-1?

cat=health

[Guest guest]

Thanks again Kim. this is me, the complusiveness, oh, and my neves go

nuts and it makes me physically ill around loud noises, even upsets

my stomach. even quite ticking type noises bother me. my PTSD has

mellowed out to, but I also know that getting around certain

chemicals/toxins can change my mood real quick. I spent alot of time

trying to understand the NO before I came across martin pall's

articles but when I did it all made sence. I think he nailed it.

thank you for posting this info.

>

> To All,

>

> Yes, when my PTSD was at its worse I had the flashbacks and the

> nightmares. They are not as common anymore. I still have the

> hypervigilence and do not like being startled. My dog is pretty

good

> at keeping me from that.....Also, just so you know alittle

obsessive

> compulsive behavior is common because serotonin is out of whack!

> Incidentally, anxiety is very common with exposures. In addition,

the

> vanilloid receptor is implicated in MCS and so the health effects

are

> the same. Please remember that mold gives off MVOCs and your

> olfactory receptors are picking it up even if you are not aware of

> it.

>

> The vanilloid receptors are located throughtout the body not just

the

> brain. " The sensitivity of this receptor to numerous

physicochemical

> factors (temperature, charge, acidity) and its widespread

> distribution in the brain and other peripheral organ systems

suggest

> that the TRPV1 may be key to the inflammation associated with

> environmental chemicals. Toxicologists have reported an initiating

> role for TRPV1 in mediating airway inflammation (e.g.,

> hyperresponsiveness, asthma) caused by chemical irritants and air

> pollutants (e.g., particulate matter, ozone, pesticides (Veronesi

et

> al., 2001)). Identifying this receptor as a common responder to

> multiple chemical toxicants could explain how diverse pollutants

and

> inhaled substances produce the respiratory dysfunction associated

> with environmental contaminants. (1) In addition, high expression

of

> TRPV1 has been detected in several inflammatory diseases of the

colon

> and ileum, whereas neuropeptides released upon sensory nerve

> stimulation triggered by TRPV1 activation seem to play a role in

> intestinal motility disorders. TRPV1 antagonists, which will soon

be

> available for clinical testing, may undergo scrutiny for the

> treatment of inflammatory diseases of the gut. (2)

>

> Supplemental:

> Symptoms of PTSD (3)

> *Re-experiencing the traumatic event, through: unwanted, intrusive

> memories dreams or nightmares, flashbacks

> *Increased arousal, in the form of:

> *Anxiety

> *Difficulty sleeping

> *Irritability

> *Difficulty concentrating

> *Being easily startled or angered

> *Increased heart rate and breathing

> *Nausea, diarrhea

>

> Intense anxiety after experiencing sights, sounds, smells or events

> that serve as reminders of the trauma and restimulate those

> receptors, or on anniversaries of the trauma

>

> *Avoidance of feeling or reminders, in the form of:

> *Sadness, depression, feelings of numbness

> *Avoiding everyday things that remind you of what happened

> *Guilt, self-doubt, feelings of helplessness or hopelessness

> *Loss of interest in activities.

>

> http://www.heirs-online.com/TRPV1.html

>

> Kim

> Health Educator and Medical Researcher

> Health Education Information and Resource Services

> kkramer@...

>

> 1.The TRPV1 Receptor: Target of Toxicants and Therapeutics

> Bellina Veronesi*,1 and Marga Oortgiesen. Toxicological Sciences

2006

> 89(1):1-3; doi:10.1093/toxsci/kfj034.

>

> 2. Activation and sensitisation of the vanilloid receptor: role in

> gastrointestinal inflammation and function

> Pierangelo Geppetti and Marcello Trevisani

> Br J Pharmacol. 2004 April; 141(8): 1313–1320. Published online

2004

> March 29. doi: 10.1038/sj.bjp.0705768.

>

> 3. Coping with Post-Traumatic Stress Disorder. What Every Woman

> Should Know. National Women's Health Resource Center, November

2005.

> http://www.healthywomen.org/ptsd/pg1.html

>

> 4. http://www.answers.com/topic/multiple-chemical-sensitivity-1?

> cat=health

>