Re: Win your mold case in court

[Guest guest]

I hasd no problems saving it as a pdf file on my desktop and it is printable.

Or you can just do the following

EVERY screen can be copied, but, articles like this that are long you have

to do it for each " screen shot "

1. hit ctrl and print screen buttons at the same time

2. open up a new word doc and hit ctrl V

that's it.....

[Guest guest]

This is what happens to the brain when you are exposed to indoor or outdoor air

pollutants, Jack D. Thrasher, Ph.D.

1: Inhal Toxicol. 2008 Mar;20(5):499-506. Links

Systemic inflammation, endothelial dysfunction, and activation in clinically

healthy children exposed to air pollutants.

Calderón-Garcidueñas L, Villarreal-Calderon R, Valencia-Salazar G,

Henríquez-Roldán C, Gutiérrez-Castrellón P, -Jardón R, Osnaya-Brizuela N,

Romero L, -Jardón R, Solt A, W.

Instituto Nacional de Pediatría, Mexico City, Mexico.

Mexico City children are chronically exposed to significant concentrations of

air pollutants and exhibit chronic respiratory-tract inflammation.

Epidemiological, controlled human exposures, laboratory-based animal models, and

in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction,

and endothelial damage mediators are upregulated upon exposure to particulate

matter (PM). Endothelial dysfunction is a critical event in cardiovascular

disease. The focus of this work was to investigate whether exposure to ambient

air pollution including PM(2.5) produces systemic inflammation and endothelial

injury in healthy children. We measured markers of endothelial activation, and

inflammatory mediators in 52 children age 8.6+/-0.1 yr, residents of Mexico City

(n: 28) or of Polotitlán (n: 24), a city with low levels of pollutants. Mexico

City children had significant increases in inflammatory mediators and

vasoconstrictors, including tumor necrosis factor (TNF)alpha, prostaglandin (PG)

E2, C-reactive protein, interleukin-1beta, and endothelin-1. There was a

significant anti-inflammatory response, and a downregulation of vascular

adhesion molecule-1, intercellular adhesion molecule-1 and -2, and selectins sE

and sL. Results from linear regression found TNF a positively associated with

24- and 48-h cumulative levels of PM(2.5), while the 7-d PM(2.5) value was

negatively associated with the numbers of white blood cells in peripheral blood

in highly exposed children. Systemic subclinical inflammation, increased

endothelin- 1, and significant downregulation of soluble adhesion molecules are

seen in Mexico City children. Children chronically exposed to fine PM above the

standard could be at risk of developing cardiovascular diseases,

atherosclerosis, stroke, and other systemic effects later in life.

PMID: 18368620 [PubMed - in process]

Jack D. Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 775-636-8513

Cell - 505-937-1150

Fax - 775-636-7403