Re: ??.MOLD EXPOSURE-- Celiac Disease - IBS -and the gut_ brain connection

[Guest guest]

I am going to comment on two of posts including this one and the one

about irritable bowel syndrome (IBS). As I have said before, there is

an awful lot of research that medical practitioners are not reading

or addressing. In the other post you posted a study about IBS. " The

results in that study were that a high incidence of illness behavior,

anxiety, sleep problems etc. were independent factors of IBS onset

and that similar relationships have been found in other " functional "

disorders. " Technically, IBS is the " disturbance in the interaction

of the gut, brain and nervous system " . I think one could consider IBS

as a progenitor or indicator of future inflammatory bowel disease, as

well as many other diseases and that the causal factors are the same

as what I have discussed in other posts. In a recent study, it was

found that IBS is linked both to allergic eczema (allergic

dermatitis) and depression. In childhood, allergic eczema is

associated with gastrointestinal dysfunction (1) which may be the

result of polymorphisms of genes for glutathione transferases and

other enzymes which would alter the detoxification processes that

would be needed to deal with the effects of food allergy on

intestinal receptors, and as you will see in the next paragraph

estradiol, and oxidative stress. Allf of which could account for the

chronic abdominal pain in children that is mentioned in the CAP

(chronic abdominal pain) study.

In that post, your question was what was the relationship to the

blood-brain barrier between boys and girls. As of right now, I have

not explored that connection too much. However, as you will find out

below the blood-brain barrier per se does not have to be involved

because the gut is considered a " second " brain. I will discuss what I

mean by this later on. To answer your question about why the CAP was

prevalent in girls more so than boys..... As I am sure you are

aware, the levels of oxidative stress is higher in women than in

men. This is because of the levels of estradiol hormones that

circulate in the female. If you notice, most of the study group in

the CAP study included those ranging from 11-14 years of age which

would be ages where estradiol levels are increasing as well as,

glucose levels are fluctuating because of insulin growth factor which

would increase oxidation and free radical production(2). In

addition, " The main hydroxylation reactions of estradiol occur in the

liver involve the CYP450 enzymes CYP3A and CYP1A2, and their chief

product is 2-hydroxyestradiol, which is a catechol estradiol and

polymorphisms of GST or CYPs would leave more estradiol to contribute

to oxidative stress. " (3)

It would be very useful to further analyze whether the results of CAP

were also due to the effects of food allergy and its effects on the

intestinal mucosa in the early stages and caused by stimulation of

intestinal receptors. Of course, a simple food sensitivity test would

identify potential food AG-AB reactions. They have already

associated that many of the symptoms of IBS are due to the pain

responses from the stimulation of pain receptors including the NMDA,

vanilloid activity and nitric oxide (4). While in the case definition

of IBS is considered to start around 20, there is no reason that

symptoms of underlying disfunction of the GI tract does not begin

early on which could be attributed to food allergy. (5) Celiac

disease is one disease where inflammation damages the cilia of the

intestines leading to the alteration of nutrient absorption caused

from the ingestion of certain protein substances called " gluten "

Celiac disease is just one of many diseases where inflammation alters

biological functioning (6). There is no doubt intestinal issues can

very well lead to psychological changes because of the effects of the

enteric nervous system in the gut uses the vanilloid and NMDA

receptors and nitric oxide as part of its major roles of

functioning. The enteric nervous system is a system that is

considered a " second brain " and has " a sophisticated nearly self-

contained network of neural circuitry, neurotransmitters and proteins

and acts independently of the " big " brain and CNS. The

neurotransmitter, serotonin acts as a messenger between the two and

is implicated in irritable bowel syndrome when levels get too high

when something else in the " gut " goes wrong. (7)

1. Predictors of abdominal pain in schoolchildren: A 4-year

population-based prospective study. A EL-Metwally, Smita Ls Halder,

G , Macfarlane, Gareth .

2.Allergy Disorders Linked With Irritable Bowel Syndrome by

Preidt. Source:American College of Allergy, Asthma & Immunology, news

release, January 2008.

http://www.heirs-online.com/Irrittable_Bowel_Syndrome.html

3. Advances in Diabetes for the Millennium: Diabetes in Women by Lois

Jovanovic, MD. Medscape General Medicine 6(3s):3, 2004.

http://www.heirs-online.com/Diabetes.html

4. Why is the Prevalence of CFS Higher in Women than in Men?

Presented by A Van Konynenburg, Ph.D at 8th International

IACFS Conference on Chronic Fatigue Syndrome, Fibromyalgia and other

Related Illnesses. Ft. Lauderdale, Florida, U.S.A. January 10-14,

2007.

http://www.heirs-online.com/Fibromyalgia.html

5. Explaining " Unexplained Illness " . Disease Paradign for Chronic

Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-

Traumatic Stress Disorder, Gulf War Syndrome and Others. Pall,

Ph.D. Harrington Park Press. A Division of Haworth Press. Pg. 65.

Copyright 2007.

6. Activation and sensitisation of the vanilloid receptor: role in

gastrointestinal inflammation and function. Pierangelo Geppetti and

Marcello Trevisani. British Journal of Pharmacology, (2004) 141, 1313–

1320.

http://www.heirs-online.com/TRPV1.html

7. Food Labeling; Gluten-Free Labeling of Foods. Department of Health

and Human Services. Food and Drug Administration. 21 CFR Part 101

[Docket No. 2005N–0279] RIN 0910–ZA26

http://www.cfsan.fda.gov/~acrobat/fr070123.pdf

8. The Other Brain Also Deals With Many Woes by Harriett Brown, New

York Times. August 23, 2005.

http://www.heirs-online.com/Irrittable_Bowel_Syndrome.html

--- In , " happyruiam " <happyru@...>

wrote:

>

> MOLD/IBS?

>

> Pain. 2007 Oct 8; : 17928145 (P,S,E,B,D) Psychosocial risk markers

> for new onset irritable bowel syndrome - Results of a large

> prospective population-based

study.................................................................

...

>

>