Guest guest Posted March 27, 2008 Report Share Posted March 27, 2008 I am going to comment on two of posts including this one and the one about irritable bowel syndrome (IBS). As I have said before, there is an awful lot of research that medical practitioners are not reading or addressing. In the other post you posted a study about IBS. " The results in that study were that a high incidence of illness behavior, anxiety, sleep problems etc. were independent factors of IBS onset and that similar relationships have been found in other " functional " disorders. " Technically, IBS is the " disturbance in the interaction of the gut, brain and nervous system " . I think one could consider IBS as a progenitor or indicator of future inflammatory bowel disease, as well as many other diseases and that the causal factors are the same as what I have discussed in other posts. In a recent study, it was found that IBS is linked both to allergic eczema (allergic dermatitis) and depression. In childhood, allergic eczema is associated with gastrointestinal dysfunction (1) which may be the result of polymorphisms of genes for glutathione transferases and other enzymes which would alter the detoxification processes that would be needed to deal with the effects of food allergy on intestinal receptors, and as you will see in the next paragraph estradiol, and oxidative stress. Allf of which could account for the chronic abdominal pain in children that is mentioned in the CAP (chronic abdominal pain) study. In that post, your question was what was the relationship to the blood-brain barrier between boys and girls. As of right now, I have not explored that connection too much. However, as you will find out below the blood-brain barrier per se does not have to be involved because the gut is considered a " second " brain. I will discuss what I mean by this later on. To answer your question about why the CAP was prevalent in girls more so than boys..... As I am sure you are aware, the levels of oxidative stress is higher in women than in men. This is because of the levels of estradiol hormones that circulate in the female. If you notice, most of the study group in the CAP study included those ranging from 11-14 years of age which would be ages where estradiol levels are increasing as well as, glucose levels are fluctuating because of insulin growth factor which would increase oxidation and free radical production(2). In addition, " The main hydroxylation reactions of estradiol occur in the liver involve the CYP450 enzymes CYP3A and CYP1A2, and their chief product is 2-hydroxyestradiol, which is a catechol estradiol and polymorphisms of GST or CYPs would leave more estradiol to contribute to oxidative stress. " (3) It would be very useful to further analyze whether the results of CAP were also due to the effects of food allergy and its effects on the intestinal mucosa in the early stages and caused by stimulation of intestinal receptors. Of course, a simple food sensitivity test would identify potential food AG-AB reactions. They have already associated that many of the symptoms of IBS are due to the pain responses from the stimulation of pain receptors including the NMDA, vanilloid activity and nitric oxide (4). While in the case definition of IBS is considered to start around 20, there is no reason that symptoms of underlying disfunction of the GI tract does not begin early on which could be attributed to food allergy. (5) Celiac disease is one disease where inflammation damages the cilia of the intestines leading to the alteration of nutrient absorption caused from the ingestion of certain protein substances called " gluten " Celiac disease is just one of many diseases where inflammation alters biological functioning (6). There is no doubt intestinal issues can very well lead to psychological changes because of the effects of the enteric nervous system in the gut uses the vanilloid and NMDA receptors and nitric oxide as part of its major roles of functioning. The enteric nervous system is a system that is considered a " second brain " and has " a sophisticated nearly self- contained network of neural circuitry, neurotransmitters and proteins and acts independently of the " big " brain and CNS. The neurotransmitter, serotonin acts as a messenger between the two and is implicated in irritable bowel syndrome when levels get too high when something else in the " gut " goes wrong. (7) 1. Predictors of abdominal pain in schoolchildren: A 4-year population-based prospective study. A EL-Metwally, Smita Ls Halder, G , Macfarlane, Gareth . 2.Allergy Disorders Linked With Irritable Bowel Syndrome by Preidt. Source:American College of Allergy, Asthma & Immunology, news release, January 2008. http://www.heirs-online.com/Irrittable_Bowel_Syndrome.html 3. Advances in Diabetes for the Millennium: Diabetes in Women by Lois Jovanovic, MD. Medscape General Medicine 6(3s):3, 2004. http://www.heirs-online.com/Diabetes.html 4. Why is the Prevalence of CFS Higher in Women than in Men? Presented by A Van Konynenburg, Ph.D at 8th International IACFS Conference on Chronic Fatigue Syndrome, Fibromyalgia and other Related Illnesses. Ft. Lauderdale, Florida, U.S.A. January 10-14, 2007. http://www.heirs-online.com/Fibromyalgia.html 5. Explaining " Unexplained Illness " . Disease Paradign for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post- Traumatic Stress Disorder, Gulf War Syndrome and Others. Pall, Ph.D. Harrington Park Press. A Division of Haworth Press. Pg. 65. Copyright 2007. 6. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Pierangelo Geppetti and Marcello Trevisani. British Journal of Pharmacology, (2004) 141, 1313– 1320. http://www.heirs-online.com/TRPV1.html 7. Food Labeling; Gluten-Free Labeling of Foods. Department of Health and Human Services. Food and Drug Administration. 21 CFR Part 101 [Docket No. 2005N–0279] RIN 0910–ZA26 http://www.cfsan.fda.gov/~acrobat/fr070123.pdf 8. The Other Brain Also Deals With Many Woes by Harriett Brown, New York Times. August 23, 2005. http://www.heirs-online.com/Irrittable_Bowel_Syndrome.html --- In , " happyruiam " <happyru@...> wrote: > > MOLD/IBS? > > Pain. 2007 Oct 8; : 17928145 (P,S,E,B,D) Psychosocial risk markers > for new onset irritable bowel syndrome - Results of a large > prospective population-based study................................................................. ... > > Quote Link to comment Share on other sites More sharing options...
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