RE: Re: doc questions

[Guest guest]

–

This information is absolutely fantastic. I do think we have

someone in mainstream medical who is willing to listen. This is why he

asked these questions. I couldn’t provide answers, but now I can show him

this post and talk more with him. He is sincerely interested in this. He is not

placating me in any way.

To answer your question you placed in Question 1, the reports

he/I asked about where the reports listed in the files section of this group.

If you click on “files” there is a list of EG Toxicity. He was

wondering since the reports all comment on EG, was there anything specific to

PEG? Then the question of what’s the difference between EG and PEG came

up. I see now where you were going with the EG Toxicity files (or whoever

posted them) – how EG is linked to PEG.

I will surely share this info with him, as well as these

responses.

Thanks for all this info – it’s very helpful. Is

there anything else you would like to relay to him? He seems to want to hear

us.

Tracie

From:

miralax [mailto:miralax ] On Behalf Of littlelief

Sent: Monday, December 08, 2008 9:16 PM

To: miralax

Subject: Re: doc questions

> >

> > 1. Are there reports pertaining to PEG, as opposed to EG?

> >

not sure what reports are being asked about? The adverse event

reports? As far as I know, the adverse event report database that

Jeanie has posted here before were all from people who had taken

PEG3350 (e.g., Miralax, GoLytely, etc.). They may have been taking

other meds at the same time, but these event reports all include PEG

not EG. To my knowledge, no one in the mainstream medical or research

communities knows of or is willing to acknowledge the hypothesis that

PEG is being degraded in the GI tract by intestinal bacterial strains

(or by other potential mechanisms) - I still haven't had time to write

up a manuscript on that....So, to my knowledge, no one in mainstream

medicine believes that EG-poisoning-like symptoms

can result from ingesting PEG.

One member here was going to ask her child's physician to test her for

EG toxicity because that child was still on Miralax and experiencing

side effects. If I recall correctly, that doctor did not go forward

with EG-toxicity testing (maybe told the parent there's no test for

that...which is wrong. . .I don't remember the details but it all

should be in the message archives here).

I had once contacted a researcher in Germany who reported some

results of giving PEG to patients - they found that a certain

percentage was not re-captured from the patients' stools. I asked her

if they checked for smaller molecules (Miralax has a molecular weight

of 3350 - so that was the only size PEG molecule they were looking for

from the stools - not smaller, possibly broken down molecules) or if

they checked for EG in the bloodstream. She said they did not, but

did not seem interested enough in my hypothesis to recheck the samples

or do more testing.

Anyway - the bottom line is that it seems that no one in mainstream

medicine is willing to acknowledge the possibility of EG being

released after ingestion of PEG and causing EG-poisoning-like symptoms

(such as oxalate crystals in urine and stool).....

> > 2. What is the molecular difference between PEG and EG?

> >

PEG is polyethylene glycol, a polymer of ethylene glycol. Like beads

on a string - where each bead is EG and the string full of beads is

PEG. I've written slightly better explanations of this in posts some

time ago - sorry I'm in hurry & can't look them up right now.

> > 3. Are the adverse reports only on people who used PEG and the

> other

> > meds listed or is it a culmination of any kind of adverse reaction

> to the

> > medications listed?

>

not sure I could answer this one. I haven't looked very closely at

any of the adverse event reports as I knew I didn't want to give my

child this stuff so I didn't need convincing by seeing all the AERs..!

HTH a little...