Open Conference Proceedings Journal 2011 immunogenicity of PEG

[Guest guest]

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> http://benthamscience.com/open/toprocj/articles/V002/104TOPROCJ.pdf

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> PEG antibodies may limit therapeutic efficacy and/or reduce PEGylated proteins

in some patients. Further evaluation suggested...

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> Page 106 discussion and suggestion of sensitivity and need for pre-screening

is BIG!

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> The rate of 22-25% of 350 healthy blood donors showing PEG antibodies is

UNBELIEVABLE!

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> This product is EVERYWHERE in our environment!

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> For the authors to recommend screening for pre-existing anti-PEG along with

the need to monitor for the development of anti-PEG throughout the course of

treatment with any PEG containing agent is substantial...the inference

spellbinding...

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