Vitamin B12, demyelination, remyelination and repair in multiple sclerosis

[Guest guest]

Subject: [soie] MS - Vitamin B12, demyelination, remyelination and repair in

multiple sclerosis

>

> J Neurol Sci. 2005 Jun 15;233(1-2):93-7.

> Vitamin B12, demyelination, remyelination and repair in multiple

> sclerosis.

>

> A, Korem M, Almog R, Galboiz Y.

>

> Division of Neuroimmunology and Multiple Sclerosis Center, Carmel

> Medical Center, Haifa 34362, Israel. millera@...

>

> Multiple Sclerosis (MS) and vitamin B12 deficiency share common

> inflammatory and neurodegenerative pathophysiological

> characteristics. Due to similarities in the clinical

> presentations and MRI findings, the differential diagnosis

> between vitamin B12 deficiency and MS may be difficult.

> Additionally, low or decreased levels of vitamin B12 have been

> demonstrated in MS patients. Moreover, recent studies suggest

> that vitamin B12, in addition to its known role as a co-factor in

> myelin formation, has important immunomodulatory and neurotrophic

> effects. These observations raise the questions of possible

> causal relationship between the two disorders, and suggest

> further studies of the need to close monitoring of vitamin B12

> levels as well as the potential requirement for supplementation

> of vitamin B12 alone or in combination with the immunotherapies

> for MS patients.

>

UK