Studies Suggesting Gluten's Role in Autoimmune Thyroid Disease

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1. Study (from Pediatrics) showing that antibodies against the thyroid and

pancreas disappear on a gluten-free diet.

http://www.ncbi.nlm.nih.gov/pubmed?term=Gluten-dependent%20diabetes-related%20an\

d%20thyroid-related%20autoantibodies%20in%20patients%20with%20celiac%20disease

2. Study (from Gastroenterology) showing that the greater the gluten exposure,

the higher the risk of autoimmune thyroid disease.

http://www.ncbi.nlm.nih.gov/pubmed/10419909

3. Here are two studies (including one from a Columbia group published in the

journal Thyroid) showing that gluten-related antibodies can bind to thyroid

follicles and the thyroid matrix suggesting a potential cause of Hashimoto's.

http://www.ncbi.nlm.nih.gov/pubmed/19014325

http://www.ncbi.nlm.nih.gov/pubmed/19352315

4. Here is a multicenter Italian study (from The American Journal of

Gastroenterology) of patients with thyroid disease and gluten-sensitive

enteropathy. One year of gluten-free diet associated with a dramatic

normalization in thyroid function while a gluten-rich diet was associated with

continued thyroid problems. Their conclusion was that " gluten withdrawal may

single-handedly reverse the (thyroid) abnormality " .

http://www.ncbi.nlm.nih.gov/pubmed/11280546

5. Italian study (from The Journal of Pediatrics) showing that in patients with

gluten-sensitive enteropathy Hashimoto's, thyroid antibodies resolve with a

gluten-free diet.

http://www.ncbi.nlm.nih.gov/pubmed/10931424

6. This is an excellent comprehensive review article (from Endocrine Reviews)

about endocrine disease and gluten sensitivity. It says that most studies

suggest that gluten plays a direct role in Hashimoto's.

http://edrv.endojournals.org/content/23/4/464.full.pdf+html

7. Study (from Diabetes & Metabolism Research and Reviews) showing that

gluten-free diet prevented/delayed autoimmune pancreatic disease (type-1

diabetes) in mice.

http://www.ncbi.nlm.nih.gov/pubmed/10585617

8. This study (from The American Journal of Gastroenterology) presented

evidence that gluten is a trigger for antibodies against the thyroid and

pancreas.

http://www.ncbi.nlm.nih.gov/pubmed/10925978

9. Study (from Clinical Gastroenterology & Hepatology) showing that celiac

patients on gluten-free diet had less autoimmune disease in other organs (like

the thyroid) than those who ate gluten. Authors concluded that " gluten-free

diet has a protective effect on endocrine organs. "

http://www.ncbi.nlm.nih.gov/pubmed/18255352

10. Study showing that among gluten sensitive patients the greater the gluten

exposure, the more significant the antibody response against the pancreas.

Authors concluded that " the development of antibodies against the pancreas is

associated with the length of the exposure to gluten. "

http://www.ncbi.nlm.nih.gov/pubmed/15478300

11. Study showing that children with gluten sensitivity have less endocrine

autoimmune disease if they follow gluten-free diet.

http://www.ncbi.nlm.nih.gov/pubmed/15709993

12. Excellent summary article (from popular magazine) about the role of gluten

in autoimmune thyroid disease.

http://www.todaysdietitian.com/newarchives/110310p52.shtml