Re: HLA

[Guest guest]

Hi There,

Thought I would share the following links re: HLA deciphering, disease

association and online databases.

The first link is like a " HLA for Dummies " (like me with HLA) and it was

oh so helpful..it relayed that DR3 is broken down into DR17 & DR18 and

as science progressed DR17 is now DRB1*0301. So if your HLA class II

comes back with a DRB1*0301 it is the same as DR17....different labs may

list the allele differently but they are the same....and this link gives

the conversions ;-) hint: scroll down the page for conversions before

accessing other clickable links at the top of the page--the clickable

linked science is still over my head as I am learning.

http://www.aseatta.org.au/nomencla.htm

And then there is a super database which cross references disease to HLA

through a pull down menu.....sometimes they only list one of the allele

names to select and not the other name of the same allele. For example

only: they may list DR17 or DRB1*0301 under class II HLA. I am still

investigating and playing with the database at this point....so take

some time to learn usage here ;-) Here is the link:

http://sdmc.krdl.org.sg:8080/fimm/DISASSOC/disassoc.html

The aforementioned info is just what I found on the internet while

trying to research personal HLA lab results. I am not an expert so those

who are drawing a blank on HLA---in a nut shell it is used for genetic

tissue match for transplantation and also indicative of the disease

genes you have been born with to my understanding. PLEASE BE ADVISED:

I am not a doctor, not advising anyone medically and just passing on

info as I come across it in researching. Remember just because you have

a gene for a disease, it is my understanding, does not mean you have the

disease or will ever get the disease itself. Hope the links help those

trying to wade through labs and interpretations without their doctorate

degrees ;-)

REPEAT: Remember just because you have a gene for a disease DOES NOT

mean you have the disease or will ever get the disease itself to my

knowledge and I am not a doctor or genetic counselor.

HTH, Carol

[Guest guest]

immature DC's, cytotoxic mycotoxins and liver damage. these are the 3

things that

have stuck out for me as I researched along. immature DC's was the

first and it gave a idea that with chronic exposure/loss of mature

DC's could cause some problems with immune functions and our bodies

ridding forign invaders. cytotoxic mycotoxins because that puts them

on the same playing field as our own cytotoxic t cells and the memic

thing comes to mind and or autoimmunity.

the liver damage based on my own experience and felling strongly that

toxic overload/TILT/high dose exposure, played it's role in TBI and

the immune system I am now left with. and how strange that this

article brings up liver transplant patients and how they suffer less

chance of graft rejection. I still have a problem with believeing or

understanding that previously healthy people can be predisposed to

this illness based on hla. maybe because it seems to me that

inherited disfunctions would show theirself at birth or soon after

and also because theres alot of once thought to be inherited diseases

that are getting known to be aquired. but obviously theres many

things that just may never be a issue until the right invader comes

along.

this is very interesting

stem cell and organ transplant

http://www.bioethics.gov/background/itescu.html

> XIV.HLA and transplantation

> www.austincc.edu/kotria/bblec14hlaSPG05.pdf

>

> RA, HLA-DR,plasmacytoid DC's

> http://arthritis-research.com/content/7/2/R230

>