Impairment of immune response / trichothecenes

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immune system is linked to the inhibitory effect of trichothecenes

(http://www.inchem.org/documents/ehc/ehc/ehc105.htm#SectionNumber:2.5)

II.4.2.5 Impairment of immune response

Experimental animal studies show that some trichothecenes affect

the immune system and thereby modify the immune response. The

impairment comprises the following functions: antibody formation;

allograft rejection; delayed hypersensitivity; and blastogenic

response to lectins. As a consequence of the impairment, decreased

resistance to microbial infection has been experimentally

established. It is likely that the impairment of the immune system

is linked to the inhibitory effect of trichothecenes on macromolecule

synthesis.