Re: SMALL VESSEL VASCULITIS,BBB,WHITE MATTER LESIONS

[Guest guest]

Jeanine,

Are you feeling better??  You have been posting some good stuff again!! 

I hope your feeling better!

a

From: who <jeaninem660@...>

Subject: [] SMALL VESSEL VASCULITIS,BBB,WHITE MATTER LESIONS

Date: Sunday, August 24, 2008, 4:50 PM

NEUROMYELITIS OPTICA WITH CLINICAL AND HISTOPATHOLOGICAL INVOLVEMENT OF

THE BRAIN

http://msj.sagepub. com/cgi/content/ abstract/ 13/5/679

CHECK OUT THE CITED ABSTRACTS FROM BELOW

http://brain. oxfordjournals. org/cgi/content/ abstract/ 125/7/1450

UBO'S(WHITE MATTER LESIONS,DEMYELINATI ON

NMO,MS,ADEM, EAE

(CSF,VESSEL LEAKS,IMMUNO)

http://brain. oxfordjournals. org/cgi/content/ full/125/ 7/1450

[Guest guest]

the findings indicate that mechanisms associated with innate immunity

may play a role in the formation of hypoxia-like demyelinating lesions

in MS.

http://brain.oxfordjournals.org/cgi/content/abstract/130/11/2800

>

> NEUROMYELITIS OPTICA WITH CLINICAL AND HISTOPATHOLOGICAL INVOLVEMENT

OF

> THE BRAIN

> http://msj.sagepub.com/cgi/content/abstract/13/5/679

> CHECK OUT THE CITED ABSTRACTS FROM BELOW

> http://brain.oxfordjournals.org/cgi/content/abstract/125/7/1450

> UBO'S(WHITE MATTER LESIONS,DEMYELINATION

> NMO,MS,ADEM,EAE

> (CSF,VESSEL LEAKS,IMMUNO)

> http://brain.oxfordjournals.org/cgi/content/full/125/7/1450

>

[Guest guest]

neuromyelitis optica with hypothalamic involvement

http://msj.sagepub.com/cgi/content/abstract/11/5/617

a central demyelinating disease with atipical features.

neuromylitis optica is usually accoiated with vasculitis.

http://msj.sagepub.com/cgi/content/abstract/10/3/308

>

> NEUROMYELITIS OPTICA WITH CLINICAL AND HISTOPATHOLOGICAL INVOLVEMENT

OF

> THE BRAIN

> http://msj.sagepub.com/cgi/content/abstract/13/5/679

> CHECK OUT THE CITED ABSTRACTS FROM BELOW

> http://brain.oxfordjournals.org/cgi/content/abstract/125/7/1450

> UBO'S(WHITE MATTER LESIONS,DEMYELINATION

> NMO,MS,ADEM,EAE

> (CSF,VESSEL LEAKS,IMMUNO)

> http://brain.oxfordjournals.org/cgi/content/full/125/7/1450

>

[Guest guest]

I've heard from several scientists that B-cells are probably involved

in mold triggered autoimmunity.

" Possible explanations for the restricted topography of NMO lesions

The reasons why the spinal cord and optic nerve are preferentially

affected in NMO are unknown. There are several possible explanations.

It is possible, although unlikely, that these sites harbour a

restricted CNS or vascular antigen. Alternatively, it may be that the

spinal cord and optic nerve are particularly vulnerable to

antibody-mediated injury due to the inherent weakness of the BBB at

these sites. The normal BBB is highly impermeable to plasma proteins

and circulating leukocytes, and thus it can protect the CNS against an

immunological reaction. However, in those areas lacking an effective

BBB, such as the spinal nerve roots, it may be proposed that

circulating pathogenic antibodies could gain access to the CNS via

these structures and diffuse out into the immediate vicinity. In EAE

models, active lesions predominantly affect the spinal cord (Lassmann,

1983Go). ON in EAE also tends to predictably occur in the retrobulbar

optic nerve (Guy and Rao, 1984Go). Lesions at these two sites are

thought to reflect the higher degree of BBB permeability in these

regions compared with the brain (Rao, 1981Go; Guy and Rao, 1984Go;

Butter et al., 1991Go). The increased BBB permeability in the spinal

cord may also be due to the inherent vascular properties of this

region, where capillaries are larger than those in the brain. Thus, on

a background of an inflammatory process in the presence of extremely

high antibody titres, lesions might preferentially, but not

exclusively, affect the spinal cord and optic nerve. This hypothesis

would be compatible with the observation that in late stages of NMO,

lesions often disseminate into other CNS regions (Wingerchuk et al.,

1999Go). "

[Guest guest]

Hi K. thanks, well actually I'm not felling to great, losts of

inflammation going on and problems with stomach and bowels, had to

stop the csm about 4 days ago, never made it up to 4 doses, I think I

may have to have another colonopsy, something pretty messed up there.

just procrastening and seeing if it well get better as I've dealt

with it before, not constapaited now but my everything is inflammed

and iy hurts, if it clears up and I can fiqure out some way around it

I well start the csm again, other than take laxitives and get severly

dehyderated, I just dont know. fells like a knife stabing my stomach

on down with every little gas pain, hurts like hell to relax my

bowels or anything else. lol's well you asked

besides that, just waiting on word about other things so what I do is

research to try to keep my mind on other things.nothing moves as fast

as I'd like it too includeing me.

>

> Jeanine,

> Are you feeling better??  You have been posting some good stuff

again!! 

> I hope your feeling better!

> a

>