Bystander effect radiation damage (new paper in PNAS) may also apply to mycotoxin damage to cells..

[Guest guest]

Just a heads-up, a paper recently published in PNAS about a " bystander

effect " causing " collateral damage " to mouse brain cells, may (IMO probably)

also applies to mycotoxin-induced damage to brain and probably other cells..

Read the abstract below..

Oncogenic bystander radiation effects in *Patched* heterozygous mouse

cerebellum

http://www.pnas.org/content/105/34/12445

Abstract

The central dogma of radiation biology, that biological effects of ionizing

radiation are a direct consequence of DNA damage occurring in irradiated

cells, has been challenged by observations that genetic/epigenetic changes

occur in unexposed " bystander cells " neighboring directly-hit cells, due to

cell-to-cell communication or soluble factors released by irradiated cells.

To date, the vast majority of these effects are described in cell-culture

systems, while *in vivo* validation and assessment of biological

consequences within an organism remain uncertain. Here, we describe the

neonatal mouse cerebellum as an accurate *in vivo* model to detect,

quantify, and mechanistically dissect radiation-bystander responses. DNA

double-strand breaks and apoptotic cell death were induced in bystander

cerebellum *in vivo*. Accompanying these genetic events, we report

bystander-related tumor induction in cerebellum of radiosensitive *Patched-1

* (*Ptch1*) heterozygous mice after x-ray exposure of the remainder of the

body. We further show that genetic damage is a critical component of *in

vivo* oncogenic bystander responses, and provide evidence supporting the

role of gap-junctional intercellular communication (GJIC) in transmission of

bystander signals in the central nervous system (CNS). These results

represent the first proof-of-principle that bystander effects are factual *in

vivo* events with carcinogenic potential, and implicate the need for

re-evaluation of approaches currently used to estimate radiation-associated

health risks.

- cancer

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- DNA

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