Acute Inhalation Toxicity of a Saline Suspension of T-2 Mycotoxin in Mice

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Accession Number : ADA190156

Title : Acute Inhalation Toxicity of a Saline Suspension of T-2

Mycotoxin in Mice

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Descriptive Note : Interim rept.

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES

FORT DETRICK MD

Personal Author(s) : Creasia, D. A. ; Nealley, M. L. ; , L. J.,

III ; York, C. G. ; Wannemacher, R. W., Jr

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Report Date : 07 NOV 1986

Pagination or Media Count : 18

Abstract : Acute Inhalation Toxicity of a Saline Suspension of T-2

Mycotoxin and Mice. CREASIA, D.A., NEALLEY, M.L., JONES, L.J., III,

YORK, C.G., WANNEMACHER, R,W,, JP., AND BUNNER, D.L.(1986). Toxicol.

Appl. Pharmacol. In a previous paper (Creasia et al., 1986), we

reported that inhalation of an ethanol/T-2 aerosol was 20 to 40

times more toxic to mice than systematic or dermal administration of

T-2. There was concern, however, that the aerosolized ethanol

vehicle might alter absorption of inhaled T-2 from the respiratory

tract. In order to eliminate this question, we exposed mice to

aerosols of T-2 in saline. We found that the LC50 for mice after a

10-min aerosol exposure of T-2 in saline was 0.04 + or - 0.008 mg T-

2/liter of air, lower than the LC50 (0.080 + or - 0.02 mg T-2/

liter) for an aerosol of T-2 in ethanol. We also found that, for any

comparable total body burden of T-2, mice exposed to T-2 in saline

retained a greater percent of T-2 in the respiratory tract than did

mice exposed to T-2 in ethanol. This suggests that the respiratory

tract may be a target organ for inhaled T-2 mycotoxin. Keywords:

Phytotoxins.

Descriptors : *TOXICITY, *PHYTOTOXINS, AEROSOLS, RESPIRATORY

SYSTEM, VEHICLES, EXPOSURE(PHYSIOLOGY), MICE, BIOLOGICAL ABSORPTION,

ORGANS(ANATOMY), SALINE SOLUTION, INHALATION, ETHANOLS, FUSARIUM.

Subject Categories : TOXICOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE

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