Re: [] Precipitation Levels May Be Associated With Autism

[Guest guest]

This is a VERY interesting paper..

This paper explains a lot of what Dr. Shoemaker talks about in Mold Warriors..

http://pharmrev.aspetjournals.org/cgi/reprint/56/1/1

(full text)

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

Catania, Stefano Gatti, Gualtiero Colombo and M. Lipton

Divisions of Internal Medicine (A.C., G.C.) and Liver Transplantation

(S.G.), Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a

Carattere Scientifico, Milano, Italy; and Zengen, Inc. (J.M.L.),

Woodland Hills, California

Abstract

I. Introduction

II. Proopiomelanocortin Gene, Gene Expression, and

Post-Translational Processing

A. Proopiomelanocortin Gene

B. Proopiomelanocortin Gene Expression

C. Post-Translational Processing of Proopiomelanocortin

D. Melanocortin Peptides

III. Melanocortin Receptors and Their Endogenous Antagonists

A. MC1 Receptor

B. MC2 Receptor

C. MC3 Receptor

D. MC4 Receptor

E. MC5 Receptor

F. Agouti and Agouti Gene-Related Protein

IV. Intracellular Signaling

V. Structure-Activity Relationship of Melanocortin Peptides

VI. Mechanism of the Anti-Inflammatory Action of Melanocortins

A. Receptor Subtypes Involved in the Anti-Inflammatory Effects

of Melanocortins

B. Influence of Melanocortins on Nuclear

Factor-{kappa}B-Mediated Transcription

C. Melanocortins Modulate Production of Chemical Mediators of

Inflammation

1. Effects in Vitro.

2. Effects in Vivo.

D. Central Control of Peripheral Inflammation

VII. Antipyretic Influences of Melanocortins

VIII. Changes in Endogenous {alpha}-Melanocyte-Stimulating Hormone

in Inflammatory Disorders

IX. Potential Therapeutic Targets Based on Preclinical Studies in

Inflammatory Disorders

A. Acute Inflammation

1. Allergic Inflammation.

2. Autoimmune Uveoretinitis.

3. Gouty Arthritis.

B. Chronic Inflammatory Diseases

1. Rheumatoid Arthritis.

2. Inflammatory Bowel Diseases.

C. Inflammation within the Brain and Neurodegenerative Disorders

D. Peripheral Neuropathies

E. Systemic Host Reactions

1. Septic Shock.

2. Systemic Vasculitis.

3. Acute Respiratory Distress Syndrome.

4. Hemorrhagic Shock.

F. Ischemia and Reperfusion Injury

G. Organ Transplantation

H. Infections

X. Advantages over Currently Used Anti-Inflammatory Drugs and

Potential Disadvantages

Also, I just saw this on another list...

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> Precipitation Levels May Be Associated With Autism

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> ... " The increased amount of time spent indoors also may expose children to

> more harmful chemicals, such as those in cleaning products, ... "

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> http://www.sciencedaily.com/releases/2008/11/081103170607.htm

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> ScienceDaily (Nov. 4, 2008) — Children living in counties with higher levels

> of annual precipitation appear more likely to have higher prevalence rates

> of autism, according to a new report. The results raise the possibility that

> an environmental trigger for autism may be associated with precipitation and

> may affect genetically vulnerable children.

>

>

> In the past 30 years, autism rates have increased from approximately one in

> 2,500 to one in 150 children, according to background information in the

> article. Some of the increase is likely due to more active monitoring and

> changes in diagnostic criteria. " Nevertheless, the possibility of a true

> increase in prevalence cannot be excluded, " the authors write. " Despite the

> increase in prevalence and the resulting increased attention paid to the

> condition, knowledge about what causes autism is limited. It is understood

> that biological factors play an important role, but environmental triggers

> may also be important. "

>

> snip...

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