Another Convert to our Reality

[Guest guest]

 

The American Society for Microbiology and the Infectious Diseases Society of

America Press Release, below.

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Medical News from

ICAAC-IDSA: A Joint Meeting of ASM and IDSA Meeting

 

ICAAC-IDSA: Fungi Geneticist Warns of Sick Building Syndrome

WASHINGTON, Oct. 29 -- It was the smell of her Hurricane Katrina-damaged home

that transformed fungi geneticist Joan , Ph.D., from a sick building

syndrome skeptic into a believer.

Dr. , who had spent years studying the genetics of fungi, was so cynical

about claims of sick buildings that she had even testified as an expert witness

for insurance companies, heaping scorn on homeowners' claims about pathological

mold and fungi.

But when Dr. stepped into her New Orleans home after the

hurricane-driven floodwaters had receded from the brick and plaster structure,

her dubious shell began to crack.

" The overwhelming obnoxiousness of the odor and of the enveloping air made me

start to believe in something I never had before -- sick building syndrome, " she

said at the Interscience Conference on Antimicrobial Agents and Chemotherapy,

held jointly with the Infectious Diseases Society of America meeting.

Dr. 's confession came during a press conference before a symposium on

the links between human disease and molds.

Absent actual infection, such as athlete's foot, Dr. 's had thought fungi

could not cause illness, especially the seemingly disparate sick buildings

afflictions -- impotence, headaches, and hemorrhages.

Then came Katrina.

The hurricane left her home uninhabitable and many of her possessions had to be

destroyed -- victims of the way fungi " eat. "

" Fungi have a strange way of gaining nutrition, " Dr. said. " They put

enzymes and acids into the environment, they turn everything out there to slime,

then they reabsorb it. They literally live in their food and in their waste. "

That process, she now thinks, may release volatile organic compounds that can

have an effect on human health.

" Perhaps what we're dealing with was not spores associated with fungi, but some

volatile compound, " suggested Dr. , who left Tulane University in New

Orleans after the hurricane to work at the School of Environmental and

Biological Sciences at Rutgers.

Dr. is in the early stages of analyzing the fungi in New Orleans homes

and then testing the biological effects of fungus-generated volatiles on worms.

In the long run, she hopes to understand -- with the help of animal models --

how fungi might affect the health of humans.

There are more than 3,000 volatile compounds produced by each individual fungus,

making it difficult for researchers to pinpoint which fungus produces which

volatile compound and what effect it might have on human health, said

Denning, M.D., of North Manchester General Hospital in Manchester, England.

" You've got multiple different fungi, multiple different chemicals, and

different susceptibilities and symptoms to work there, " Dr. Denning said. " It's

quite a complex area. "

Dr. Denning's own work, presented here, concerned a randomized clinical trial in

which 60 severe asthma patients were treated with the antifungal medication

itraconazole or given placebo.

He said the patients given the itraconazole had a " very significant benefit in

quality of life, " among 60% of the patients. They also relied on fewer steroids

and inhalers to manage their asthma.

The reason for the success of the treatment, he suggested, is that some people

are " hypersensitive " to fungi.

" These individuals are sensitized so we can detect an abnormal immune response,

and those fungi seem to aggravate their asthma, " he said.

Primary source: ICAAC-IDSA Meeting

Complete ICAAC-IDSA Coverage

 

http://www.medpagetoday.com/MeetingCoverage/ICAAC-IDSA/11529