Oxidative stress in fibromyalgia and its relationship to symptoms.

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Clin Rheumatol. 2008 Dec 17. [Epub ahead of print]

Oxidative stress in fibromyalgia and its relationship to symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/19089486?dopt=AbstractPlus Chung CP,

Titova D, Oeser A, Randels M, Avalos I, Milne GL, Morrow JD, Stein CM.

Department of Medicine, School of Medicine, Vanderbilt University, Nashville,

TN, USA.

Oxidative stress is thought to play a role in the pathogenesis of

fibromyalgia. We examined the hypothesis that oxidative stress was increased in

patients with fibromyalgia and related to the severity of symptoms. Urinary

F(2)-isoprostane excretion was measured in 48 patients with fibromyalgia and

compared to those of 96 control subjects. In patients, we examined the

association between oxidative stress and symptoms. Patients with fibromyalgia

were significantly more symptomatic than control subjects, but urinary

F(2)-isoprostane excretion did not differ significantly (2.3 +/- 1.9 vs. 2.8 +/-

2.2 ng/mg creatinine, p = 0.16). In patients with fibromyalgia, F(2)-isoprostane

excretion was associated with fatigue visual analog scale (rho = 0.30, p = 0.04)

but not with pain, quality of life, functional capacity, depression, number of

tender points, or overall impact of fibromyalgia. Oxidative stress is not

increased in patients with fibromyalgia, but as was

previously found in patients with systemic lupus erythematosus, oxidative

stress was associated with fatigue.

PMID: 19089486 [PubMed - as supplied by publisher]