Doctors discover the Earth is Round

[Guest guest]

The same doctors who don't believe a word of what WE tell them we are suffering

from, due to mold exposure, have decided to believe their lab rats.  Great!

Probably, after another 20 or 30 years of cutting up dead rats, they will

announce that THEY have discovered that mold also causes a TOXIC reaction. Ain't

medical science wonderful?

 

Joe

...........................................................

 

Chronic intranasal administration of Aspergillus fumigatus spores leads to

aggravation of airway inflammation and remodelling in asthmatic rats

Fu-Sheng GAO, Jian-Ou QIAO, Yi ZHANG AND Xian-Qiao JIN

Department of Respiratory Medicine, First People's Hospital Affiliated to

Shanghai Jiao Tong University, Shanghai, China

Correspondence to  Xian-Qiao Jin, Department of Respiratory Medicine, First

People's Hospital Affiliated to Shanghai Jiao Tong University, Haining Road 100,

Shanghai 200080, China. Email: jinxianqiao@...

Copyright Journal compilation © 2009 Asian Pacific Society of Respirology

KEYWORDS

airway remodelling • Aspergillus fumigatus • asthma • bronchial

hyperresponsiveness • inflammation

ABSTRACT

Background and objective:  Epidemiological evidence indicates a close link

between exposure to fungi and deterioration of asthma. However, the role of

fungi as an exogenous precipitant for initiation and progression of asthma has

been incompletely explored. In this study, the effects of Aspergillus fumigatus

exposure on airway inflammation and remodelling in a rat model of chronic asthma

were investigated.

Methods:  The rat model of chronic asthma was established by systemic

sensitization and repeated challenge with ovalbumin (OVA). The asthmatic rats

were exposed to chronic intranasal inhalation of A. fumigatus spores. Changes in

airway inflammation, remodelling and BHR were measured after exposure to the

fungus.

Results:  Chronic inhalation of A. fumigatus spores elevated the production of

T helper 2 (Th2) cytokines, increased the concentration of total serum IgE, and

resulted in the recruitment of eosinophils and lymphocyte infiltration into the

airways of asthmatic rats. Goblet cell hyperplasia, mucus hyperproduction and

subepithelial collagen deposition were also induced by inhalation of the fungus.

The remodelling changes induced by inhalation of the fungus paralleled the

changes in BHR in this rat model of asthma.

Conclusions:  Chronic exposure to A. fumigatus aggravated Th2 airway

inflammation, promoted airway remodelling and increased BHR in OVA-sensitized

and -challenged rats.

 

http://www3.interscience.wiley.com/journal/121682088/abstract

 

 

[Guest guest]

LOL Joe, You got that right. What a load of rat poison...

 Sickbuilding Syndrome should be one of your greatest

concerns.www.biotoxin.info

The same doctors who don't believe a word of what WE tell them we are suffering

from, due to mold exposure, have decided to believe their lab rats.  Great!

Probably, after another 20 or 30 years of cutting up dead rats, they will

announce that THEY have discovered that mold also causes a TOXIC reaction. Ain't

medical science wonderful?

 

Joe

[Guest guest]

tomorrow on " doctors " on tv, they are discussing INDOOR toxins.

v.

From: josephsalowitz@... <josephsalowitz@...>

Subject: [] Doctors discover the Earth is Round

" " < >

Date: Tuesday, March 31, 2009, 6:32 AM

The same doctors who don't believe a word of what WE tell them we are suffering

from, due to mold exposure, have decided to believe their lab rats.  Great!

Probably, after another 20 or 30 years of cutting up dead rats, they will

announce that THEY have discovered that mold also causes a TOXIC reaction. Ain't

medical science wonderful?

 

Joe

.............. ......... ......... ......... ......... ......... .

 

Chronic intranasal administration of Aspergillus fumigatus spores leads to

aggravation of airway inflammation and remodelling in asthmatic rats

Fu-Sheng GAO, Jian-Ou QIAO, Yi ZHANG AND Xian-Qiao JIN

Department of Respiratory Medicine, First People's Hospital Affiliated to

Shanghai Jiao Tong University, Shanghai, China

Correspondence to  Xian-Qiao Jin, Department of Respiratory Medicine, First

People's Hospital Affiliated to Shanghai Jiao Tong University, Haining Road 100,

Shanghai 200080, China. Email: jinxianqiao@ 126.com

Copyright Journal compilation © 2009 Asian Pacific Society of Respirology

KEYWORDS

airway remodelling • Aspergillus fumigatus • asthma • bronchial

hyperresponsiveness • inflammation

ABSTRACT

Background and objective:  Epidemiological evidence indicates a close link

between exposure to fungi and deterioration of asthma. However, the role of

fungi as an exogenous precipitant for initiation and progression of asthma has

been incompletely explored. In this study, the effects of Aspergillus fumigatus

exposure on airway inflammation and remodelling in a rat model of chronic asthma

were investigated.

Methods:  The rat model of chronic asthma was established by systemic

sensitization and repeated challenge with ovalbumin (OVA). The asthmatic rats

were exposed to chronic intranasal inhalation of A. fumigatus spores. Changes in

airway inflammation, remodelling and BHR were measured after exposure to the

fungus.

Results:  Chronic inhalation of A. fumigatus spores elevated the production of

T helper 2 (Th2) cytokines, increased the concentration of total serum IgE, and

resulted in the recruitment of eosinophils and lymphocyte infiltration into the

airways of asthmatic rats. Goblet cell hyperplasia, mucus hyperproduction and

subepithelial collagen deposition were also induced by inhalation of the fungus.

The remodelling changes induced by inhalation of the fungus paralleled the

changes in BHR in this rat model of asthma..

Conclusions:  Chronic exposure to A. fumigatus aggravated Th2 airway

inflammation, promoted airway remodelling and increased BHR in OVA-sensitized

and -challenged rats.

 

http://www3. interscience. wiley.com/ journal/12168208 8/abstract

 

 

[Guest guest]

What channel is that?

>

> tomorrow on " doctors " on tv, they are discussing INDOOR toxins.

> v.