Microbial volatile organic compounds

[Guest guest]

Crit Rev Toxicol. 2009;39(2):139-93. Links

Microbial volatile organic compounds.

http://www.ncbi.nlm.nih.gov/pubmed/19204852 Korpi A, Järnberg J, Pasanen

AL.

University of Kuopio, Department of Environmental Science, Kuopio, Finland.

anne.korpi@...

Microbial volatile organic compounds (MVOCs) are a variety of compounds formed

in the metabolism of fungi and bacteria. Of more than 200 compounds identified

as MVOCs in laboratory experiments, none can be regarded as exclusively of

microbial origin or as specific for certain microbial species. Thus, the

recognition of microbially contaminated areas by MVOC measurements is not

successful with current methods. In this review, the basic physical and

chemical properties of 96 typical MVOCs have been summarised. Of these,

toxicological and exposure data were gathered for the 15 MVOCs most often

analysed and reported in buildings with moisture and microbial damage. The most

obvious health effect of MVOC exposure is eye and upper-airway irritation.

However, in human experimental exposure studies, symptoms of irritation have

appeared at MVOC concentrations several orders of magnitude higher than those

measured indoors (single MVOC levels in indoor environments have

ranged from a few ng/m(3) up to 1 mg/m(3)). This is also supported by

dose-dependent sensory-irritation response, as determined by the American

Society for Testing and Materials mouse bioassay. On the other hand, the

toxicological database is poor even for the 15 examined MVOCs. There may be

more potent compounds and other endpoints not yet evaluated.

PMID: 19204852 [PubMed - indexed for MEDLINE]

[Guest guest]

a: thanks for posting this. As I have pointed out in this forum MVOCs

are only part of the problem, but do add to the toxic situation of the indoor

environment resulting from microbial growth. The other culprits include

pathogenic and nonpathogenic gram negative and positive bacterial, multiple mold

species, particulates that carry allergens, VOCs and mycotoxins, extracellular

microbial proteins, beta glucan, galactomannans and endotoxins. All of these

impinge upon the occupants of such structures with interctions including

synergism between endotoxins and mycotoxins.

Jack D. Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

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[Guest guest]

Jack,

Thanks for the reminder of the multiplicity of exposures from

indoor dampness. As another example of how research is

continuing consider the recent WHO Collaborating Centre for

Housing and Health Newsletter, No. 4 March, 2009.

Prof Aino Nevalainen, Dept Environmental Health, Natl Inst for

Health and Welfare, Finland, wrote an editorial suggesting that

another organism, actinobacteria, may play a major role in health

effects from indoor dampness.

The evidence is expanding, not contracting.

Carl Grimes

Healthy Habitats LLC

-----

>

> a: thanks for posting this. As I have pointed out in this forum MVOCs

are only part of the problem,

> but do add to the toxic situation of the indoor environment resulting from

microbial growth. The other

> culprits include pathogenic and nonpathogenic gram negative and positive

bacterial, multiple mold species,

> particulates that carry allergens, VOCs and mycotoxins, extracellular

microbial proteins, beta glucan,

> galactomannans and endotoxins. All of these impinge upon the occupants of such

structures with interctions

> including synergism between endotoxins and mycotoxins.

>

> Jack D. Thrasher, Ph.D.

> Toxicologist/Immunotoxicologist/Fetaltoxicologist

> www.drthrasher.org

> toxicologist1@...

> Off: 916-745-4703

> Cell: 575-937-1150

>

> L. Crawley, M.ED., LADC

> Trauma Specialist

> sandracrawley@...

> 916-745-4703 - Off

> 775-309-3994 - Cell

>

> This message and any attachments forwarded with it is to be considered

privileged and confidential. The

> forwarding or redistribution of this message (and any attachments) without my

prior written consent is

> strictly prohibited and may violate privacy laws. Once the intended purpose of

this message has been served,

> please destroy the original message contents. If you have received this

message in error, please reply

> immediately to advise the sender of the miscommunication and then delete the

message and any copies you

> have printed. Thank you in advance for your compliance.

>

>

[Guest guest]

Carl: Several species of the following genera have been isolates:

Streptomyces, Mycobacterium and Nocardia from wet building materials.

Streptomyces and Nocardia produce exotoxins. Several Streptomyces species are

sources of antibiotics and chemotherpeutics. Mycobacterium avium complex is on

the rise worldwide. The actinobacter are also capable of causing multiple small

tumors called mycetomas.

Jack D. Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

This message and any attachments forwarded with it is to be considered

privileged and confidential. The forwarding or redistribution of this message

(and any attachments) without my prior written consent is strictly prohibited

and may violate privacy laws. Once the intended purpose of this message has been

served, please destroy the original message contents. If you have received this

message in error, please reply immediately to advise the sender of the

miscommunication and then delete the message and any copies you have printed.

Thank you in advance for your compliance.

[Guest guest]

Thanks, Jack, for the ever increasing list of concerns of wet

buildings and health. Another part of the actinobacteria

involvement is the leftover waste. In other words, its not just the

organism but the whole complex of what the recent AIHA book

identifies as " filth caused by moisture. "

Carl Grimes

Healthy Habitats LLC

-----

>

> Carl: Several species of the following genera have been isolates:

Streptomyces, Mycobacterium and Nocardia

> from wet building materials. Streptomyces and Nocardia produce exotoxins.

Several Streptomyces species

> are sources of antibiotics and chemotherpeutics. Mycobacterium avium complex

is on the rise worldwide.

> The actinobacter are also capable of causing multiple small tumors called

mycetomas.

>

> Jack D. Thrasher, Ph.D.

> Toxicologist/Immunotoxicologist/Fetaltoxicologist

> www.drthrasher.org

> toxicologist1@...

> Off: 916-745-4703

> Cell: 575-937-1150

>

> L. Crawley, M.ED., LADC

> Trauma Specialist

> sandracrawley@...

> 916-745-4703 - Off

> 775-309-3994 - Cell

>

> This message and any attachments forwarded with it is to be considered

privileged and confidential. The

> forwarding or redistribution of this message (and any attachments) without my

prior written consent is

> strictly prohibited and may violate privacy laws. Once the intended purpose of

this message has been served,

> please destroy the original message contents. If you have received this

message in error, please reply

> immediately to advise the sender of the miscommunication and then delete the

message and any copies you

> have printed. Thank you in advance for your compliance.

>

>

[Guest guest]

Is the AIHI book expensive to buy?

>

> Thanks, Jack, for the ever increasing list of concerns of wet

> buildings and health. Another part of the actinobacteria

> involvement is the leftover waste. In other words, its not just the

> organism but the whole complex of what the recent AIHA book

> identifies as " filth caused by moisture. "

>

> Carl Grimes

> Healthy Habitats LLC

[Guest guest]

The non-member price for the AIHA book " Recognition, Evaluation and Control of

Indoor Mold " is $190.00. www.aiha.org

________________________________

From: barb1283 <barb1283@...>

Sent: Monday, March 9, 2009 5:28:37 PM

Subject: [] Re: Microbial volatile organic compounds

Is the AIHI book expensive to buy?

>

> Thanks, Jack, for the ever increasing list of concerns of wet

> buildings and health. Another part of the actinobacteria

> involvement is the leftover waste. In other words, its not just the

> organism but the whole complex of what the recent AIHA book

> identifies as " filth caused by moisture. "

>

> Carl Grimes

> Healthy Habitats LLC