Acute Respiratory Tract Toxicity of the Trichothecene Mycotoxin, T-2 Toxin.

[Guest guest]

Accession Number : ADA190175

http://oai.dtic.mil/oai/oai?

verb=getRecord & metadataPrefix=html & identifier=ADA190175

Title : Acute Respiratory Tract Toxicity of the Trichothecene

Mycotoxin, T-2 Toxin.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES

FORT DETRICK MD

Personal Author(s) : Creasia, A. ; Lambert, J.

Handle / proxy Url :

http://handle.dtic.mil/100.2/ADA190175 Check NTIS

Availability...

Report Date : 31 MAR 1987

Pagination or Media Count : 25

Abstract : The systemic toxicology of trichothecene mycotoxins in a

variety of laboratory and farm animals is well documented. Toxicity

reports following respiratory exposure, however, are mostly

anecdotal. For instance, Ismailson first called attention to

toxicosis secondary to mold spore inhalation in a binder twine

factory. More recently, Forgacs described symptoms of a severe

pharyngitis, or burning sensation in the nose accompanied by bloody

nasal discharge and a moderate to severe cough in workers that

developed stachybotryotoxicosis after inhaling dusts from

Stachybotrys-contaminated straw. Ueno reported 100% lethality of

five mice 5 days after a 160-minute exposure to 140 ppb of T-2

mycotoxin. However, no information on aerosol generation or aersol

characterization was given, and only very limited information on

exposure conditions was presented. A report issued in 1983 by the

Committee on Protection Against Trichothecene Mycotoxins noted that

there was a lack of information on inhalation exposure to

trichothecene toxins and recommended that this route of exposure be

studied. Keywords: Phytotoxins.

Descriptors : *PHYTOTOXINS, *RESPIRATORY SYSTEM, *TOXICITY,

AEROSOL GENERATORS, ANIMALS, COMBUSTION, DRAINAGE, FUNGI,

HEMORRHAGE, INHALATION, MOLDS(FORMS), NOSES, NOSE(ANATOMY), SENSES

(PHYSIOLOGY), SIGNS AND SYMPTOMS, SPORES, TOXICOLOGY, TOXINS AND

ANTITOXINS, EXPOSURE(PHYSIOLOGY), RESPIRATORY DISEASES, LYMPHOCYTES.

Subject Categories : TOXICOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE

Search DTIC's Public STINET for similiar documents.

Members of the public may purchase hardcopy documents from the

National Technical Information Service.