VeriTox has a new paper re: INHALED mycotoxins

[Guest guest]

_The Concentration of No Toxicologic Concern (CoNTC) and Airborne Mycotoxins

- Journal of Toxicology and Environmental Health,._

(http://www.informaworld.com/smpp/content~db=all?content=10.1080/152873908027063\

89)

Authors: D. Hardin a; Coreen A. Robbins a; Payam Fallah b; Bruce J.

Kelman a

Affiliations: a Veritox®, Inc, Redmond, Washington, USA b Indoor

Environmental Hygiene Laboratory (IDEHL®), Redmond, Washington, USA

DOI: 10.1080/15287390802706389

Publication Frequency: 24 issues per year

Published in: _Journal of Toxicology and Environmental Health, Part A_

(http://www.informaworld.com/smpp/title~content=t713667303~db=all) , Volume

_72_

(http://www.informaworld.com/smpp/title~content=t713667303~db=all~tab=issueslist

~branches=72#v72) , Issue _9 _

(http://www.informaworld.com/smpp/title~content=g909689367~db=all) January 2009

, pages 585 - 598

Subjects: _Environmental & Ecological Toxicology_

(http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~append=71\

4594144,714594094,7145941

48#subject714594148) ; _Environmental Health_

(http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~append=71\

4593678,714593598,725338661#s

ubject725338661) ;

Formats available: HTML (English) : PDF (English)

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Abstract

The threshold of toxicologic concern (TTC) concept was developed as a method

to identify a chemical intake level that is predicted to be without adverse

human health effects assuming daily intake over the course of a 70-yr life

span. The TTC values are based on known structure-activity relationships and do

not require chemical-specific toxicity data. This allows safety assessment

(or prioritization for testing) of chemicals with known molecular structure

but little or no toxicity data. Recently, the TTC concept was extended to

inhaled substances by converting a TTC expressed in micrograms per person per

day

to an airborne concentration (ng/m3), making allowance for intake by routes

in addition to inhalation and implicitly assuming 100% bioavailability of

inhaled toxicants. The resulting concentration of no toxicologic concern

(CoNTC), 30 ng/m3, represents a generic airborne concentration that is expected

to

pose no hazard to humans exposed continuously throughout a 70-yr lifetime.

Published data on the levels of mycotoxins in agricultural dusts or in fungal

spores, along with measured levels of airborne mycotoxins, spores, or dust in

various environments, were used to identify conditions under which mycotoxin

exposures might reach the CoNTC. Data demonstrate that airborne

concentrations of dusts and mold spores sometimes encountered in agricultural

environments

have the potential to produce mycotoxin concentrations greater than the

CoNTC. On the other hand, these data suggest that common exposures to

mycotoxins

from airborne molds in daily life, including in the built indoor environment,

are below the concentration of no toxicologic concern.

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