Re: 10-year old daughter with Hashimoto's-saw Gastroenterologist today/repeated labs

[Guest guest]

Hi ,

Your daughter's results can be normal meaning she doesn't have Celiac disease.

But, she could have the genes that predispose to gluten intolerance. I suggest

you actually get a hard copy of the resuls and all test reports.

As an example, test results of HLA-DQ Gene Molecular analysis: HLA-DQB1*0301,

0301 means DQ7, DQ7. The way you interpret the 0301 is that the first two

digits show DQ3 and the last two digits show a subtype of 1 - which is also

called a DQ7.

This stuff is confusing because scientists first learned about DQ1-DQ4, but then

realized that what they called DQ1 actually was comprised of two different

genes, thus the subtypes 1 and 2 for DQ1 (also referred to as DQ5 and DQ6

respectively) and then the same for DQ3 with its 3 subtypes - thus you have DQ7,

DQ8 and DQ9. Thus, DQ1 and DQ3 are rarely used anymore. (I mistakenly added them

in as gluten intolerant marker before.) Celiacs is DQ2/8 while gluten

intolerance includes DQ5, 6, 7, and 9.

The above example is a really good example of why having the full HLA-DR gene

testing can be useful. My daughter has one DQ7 aka 0301 (along with DQ9 aka

0303) and it wasn't until we had the full gene testing done that we could figure

out her remaining big issues. Depending upon your DRB1 and DRB3, DRB4 and DRB5

results, you could have a genotype that predisposes you to become very ill due

to exposure to any kind of toxin - mold, heavy metals, toxins produced by

infections - i.e., bacterial, fungal, viral and parasitic infections all result

in additional biotoxins in your body. So if anyone has a DRB1 (not to be

mistaken for DQ) of 4 along with DQ7, then s/he has that genotype where the body

does NOT recognize the toxins, so it doesn't remove them leading to severe

illness on top of AITD. Besides being predisposed to gluten intolerance the DQ6

genotype also correlates with a predisposition to become very ill upon exposure

to mold.

This stuff is complicated and many doctors are clueless because they do NOT do

this testing on a regular basis. Research so you know the truth. Many Endos do

NOT keep up on new research.

Furthermore, I encourage you to look at the TSI and TBII (TRab) tests if

anything is detectable (even in the normal ranges) you may be in for a

continuous whirlwind of unknowledgeable medical professionals like my husband

and I experienced before getting reliable and efficient medical care for our

daughter.

Her initial TSI/TBII labs were normal and very low but nonetheless detectable.

It is NOT normal to have *any* TSI or TBII whatsoever. These antibodies can

increase even when FT3 and FT4 come back into the normal reference range. We

have found that all PedEndos and most Endos do NOT even understand autoimmune

thyroid disease. It is the MOST unDx'd and Under treated disease in the world.

Some drs will not test because they don't know how to properly read these tests.

I will not go into detail about interpreting these tests here, but I can explain

if the need arises.

My last suggestion is if she has heart issues such as a fast heart beat get her

on a beta blocker before heart damage occurs. My daughter took a BB before we

found her competent help. Currently she takes a anti-thyroid drug and a

thyroxine (synthetic T4) med.

Best wishes to you and your daughter,

~Bj aka

> & gt;

> & gt; Hi everyone,

> & gt;

> & gt; As you may remember, our 10-year old daughter was diagnosed with

Hashimoto's 18 days ago when she was found to be hyperthyoid with a high thyroid

peroxidase antibody titer. Her other antibody levels were negative and our endo

told us that she was in the active inflammatory phase of Hashimoto's when the

thyroid hormone gets released into the blood stream causing high levels and that

if this continues, eventually she will be hypothyroid.

> & gt;

> & gt; Our pediatric endocrinologist recommended that we do nothing for now and

recheck her thyroid blood tests in a month or two. She said levels take at least

a month or longer to come down significantly.

> & gt;

> & gt; Well, we didn't wait that long to recheck her blood test. We waited 18

days. In the last 18 days, we went gluten-free because of all the studies I've

read suggesting that a gluten-free diet may help autoimmune thyroid issues

especially in gluten sensitive folks.

> & gt;

> & gt; Well, I have some good news. Thankfully our daughter's thyroid functions

tests were much better today - almost normal. Her free T3 and T4 have come down

dramatically and her TSH is better. Her thyroid peroxidase antibodies are still

very positive but our endocrinologist said that can stay high for a long time.

Please see below for today's results and the results from 3 weeks ago (June 28).

The normal values are on the right side.

> & gt;

> & gt; We also checked serologies for Celiac today (including the genetic tests

HLA DQ-2 and DQ-8), but we won't get those back until later in the week. The

gastroenterologist that we saw today said that even if teh Celiac tests all come

back normal, there's still a reasonable likelihood that our daughter is gluten

sensitive and that it's very possible that the Hashimoto's is related to gluten.

> & gt;

> & gt; The plan, for now, is to continue the gluten-free diet and recheck

thyroid blood tests again in two weeks - hopefully they'll be normal by then.

> & gt;

> & gt; We're also planning to see an allergist next week.

> & gt;

> & gt; Thanks, everyone for all the advice.

> & gt;

> & gt;

> & gt;

> & gt; July 16, 2012 (today)

> & gt;

> & gt; FREE T3 INDEX PROFILE

> & gt; FREE T3 INDEX @ 210 78-162

> & gt; T-UPTAKE 0.9 TBI 0.9-1.3

> & gt; T3,TOTAL @ 189 ng/dL 85-185

> & gt; FREE T4 INDEX PROFILE

> & gt; FREE T4 INDEX @ 14.2 4.5-10.5

> & gt; T4,TOTAL @ 12.8 mcg/dL 4.9-11.4

> & gt; T-UPTAKE 0.9 TBI 0.9-1.3

> & gt; THYROID PEROXIDASE ANTIBODY @ & gt; 600 IU/mL & lt; or = 20

> & gt; TSH 0.82 mcIU/mL 0.3-4.7

> & gt;

> & gt;

> & gt; June 28, 2012

> & gt;

> & gt; FREE T3 INDEX PROFILE

> & gt; FREE T3 INDEX @ 558 78-162

> & gt; T-UPTAKE @ 0.5 TBI 0.9-1.3

> & gt; T3,TOTAL @ 279 ng/dL 85-185

> & gt; FREE T4 INDEX PROFILE

> & gt; FREE T4 INDEX @ 33.0 4.5-10.5

> & gt; T4,TOTAL @ 16.5 mcg/dL 4.9-11.4

> & gt; T-UPTAKE @ 0.5 TBI 0.9-1.3

> & gt; THYROID PEROXIDASE ANTIBODY @ & gt; 600 IU/mL & lt; or = 20

> & gt; TSH 0.43 mcIU/mL 0.3-4.7

> & gt;

>