Vitamin D may exacerbate autoimmune disease

[Guest guest]

This is very interesting, since most of us are trying to clear our systems of

pathogens, the last thing we want is to give them running room to explore the

rest of our bodys.

Vitamin D may exacerbate autoimmune disease

http://www.eurekalert.org/pub_releases/2009-04/arf-vdm040809.php

Deficiency in vitamin D has been widely regarded as contributing to autoimmune

disease, but a review appearing in Autoimmunity Reviews explains that low levels

of vitamin D in patients with autoimmune disease may be a result rather than a

cause of disease and that supplementing with vitamin D may actually exacerbate

autoimmune disease.

Authored by a team of researchers at the California-based non-profit

Autoimmunity Research Foundation, the paper goes on to point out that molecular

biologists have long known that the form of vitamin D derived from food and

supplements, 25-hydroxyvitamin D (25-D), is a secosteroid rather than a vitamin.

Like corticosteroid medications, vitamin D may provide short-term relief by

lowering inflammation but may exacerbate disease symptoms over the long-term.

The insights are based on molecular research showing that 25-D inactivates

rather than activates its native receptor - the Vitamin D nuclear receptor or

VDR. Once associated solely with calcium metabolism, the VDR is now known to

transcribe at least 913 genes and largely control the innate immune response by

expressing the bulk of the body's antimicrobial peptides, natural antimicrobials

that target bacteria.

Written under the guidance of professor Trevor Marshall of Murdoch University,

Western Australia, the paper contends that 25-D's actions must be considered in

light of recent research on the Human Microbiome. Such research shows that

bacteria are far more pervasive than previously thought – 90% of cells in the

body are estimated to be non-human – increasing the likelihood that autoimmune

diseases are caused by persistent pathogens, many of which have yet to be named

or have their DNA characterized.

Marshall and team explain that by deactivating the VDR and subsequently the

immune response, 25-D lowers the inflammation caused by many of these bacteria

but allows them to spread more easily in the long-run. They outline how

long-term harm caused by high levels of 25-D has been missed because the

bacteria implicated in autoimmune disease grow very slowly. For example, a

higher incidence in brain lesions, allergies, and atopy in response to vitamin D

supplementation have been noted only after decades of supplementation with the

secosteroid.

Furthermore, low levels of 25-D are frequently noted in patients with

autoimmune disease, leading to a current consensus that a deficiency of the

secosteroid may contribute to the autoimmune disease process. However, Marshall

and team explain that these low levels of 25-D are a result, rather than a

cause, of the disease process. Indeed, Marshall's research shows that in

autoimmune disease, 25-D levels are naturally down-regulated in response to VDR

dysregulation by chronic pathogens. Under such circumstances, supplementation

with extra vitamin D is not only counterproductive but harmful, as it slows the

ability of the immune system to deal with such bacteria.

The team points out the importance of examining alternate models of vitamin D

metabolism.

" Vitamin D is currently being recommended at historically unprecedented doses, "

states Amy Proal, one of the paper's co-authors. " Yet at the same time, the rate

of nearly every autoimmune disease continues to escalate. "

###

For the past five years, Autoimmunity Research Foundation has been running an

observational study in which patients are administered pulsed low dose

antibiotics and a VDR agonist in order to kill chronic bacteria implicated in

their diseases. Specific data on the cohort was recently presented by CAPT

H. , USPHS (ret) at the International Congress on Autoimmunity in

Porto, Portugal:

Transcript:

http://autoimmunityresearch.org/transcripts/ICA2008_Transcript_Tom.pdf

Video: http://vimeo.com/1789735

Resources

Citation: Albert PJ et al. In press. Autoimmunity Reviews. " Vitamin D: The

alternative hypothesis. "

Full-text preprint:

http://autoimmunityresearch.org/transcripts/AR-Albert-VitD.pdf

DOI: http://dx.doi.org/10.1016/j.autrev.2009.02.011

Presentation on clinical data:

Transcript:

http://autoimmunityresearch.org/transcripts/ICA2008_Transcript_Tom.pdf

Video: http://vimeo.com/1789735

Foundation website: http://AutoimmunityResearch.org/

---------------------------------

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[Guest guest]

I don't know why I needed extra calcium after my mold exposure, and

have needed it since (10 years now). If I don't take it, my whole body

cramps up.

Barth

d> ---

d> All this conflicting information is just too much sometimes. All the EI

clinics here have just started testing for Vit D deificiency and " insist " that

you need to supplement it to get well. Its is

d> SO confusing to say the least. D

d> In , a Townsend <kmtown2003@...> wrote:

>>

>>

>> This is very interesting, since most of us are trying to clear our systems of

pathogens, the last thing we want is to give them running room to explore the

rest of our bodys.

>>

[Guest guest]

Well, they had best come up with a remedy then. Since the heart is a

muscle, I'm not going to risk a heart attack by not taking extra D.

Barth

---

KT> This is very interesting, since most of us are trying to clear our systems

of pathogens, the last thing we want is to give them running room to explore the

rest of our bodys.

KT> Vitamin D may exacerbate autoimmune disease

KT> http://www.eurekalert.org/pub_releases/2009-04/arf-vdm040809.php

KT> Deficiency in vitamin D has been widely regarded as contributing to

autoimmune disease, but a review appearing in Autoimmunity Reviews explains that

low levels of vitamin D in patients with

KT> autoimmune disease may be a result rather than a cause of disease and that

supplementing with vitamin D may actually exacerbate autoimmune disease.

KT> Authored by a team of researchers at the California-based non-profit

Autoimmunity Research Foundation, the paper goes on to point out that molecular

biologists have long known that the form of

KT> vitamin D derived from food and supplements, 25-hydroxyvitamin D (25-D), is

a secosteroid rather than a vitamin. Like corticosteroid medications, vitamin D

may provide short-term relief by

KT> lowering inflammation but may exacerbate disease symptoms over the

long-term.

KT> The insights are based on molecular research showing that 25-D inactivates

rather than activates its native receptor - the Vitamin D nuclear receptor or

VDR. Once associated solely with calcium

KT> metabolism, the VDR is now known to transcribe at least 913 genes and

largely control the innate immune response by expressing the bulk of the body's

antimicrobial peptides, natural

KT> antimicrobials that target bacteria.

KT> Written under the guidance of professor Trevor Marshall of Murdoch

University, Western Australia, the paper contends that 25-D's actions must be

considered in light of recent research on the

KT> Human Microbiome. Such research shows that bacteria are far more pervasive

than previously thought – 90% of cells in the body are estimated to be non-human

– increasing the likelihood that

KT> autoimmune diseases are caused by persistent pathogens, many of which have

yet to be named or have their DNA characterized.

KT> Marshall and team explain that by deactivating the VDR and subsequently the

immune response, 25-D lowers the inflammation caused by many of these bacteria

but allows them to spread more easily

KT> in the long-run. They outline how long-term harm caused by high levels of

25-D has been missed because the bacteria implicated in autoimmune disease grow

very slowly. For example, a higher

KT> incidence in brain lesions, allergies, and atopy in response to vitamin D

supplementation have been noted only after decades of supplementation with the

secosteroid.

KT> Furthermore, low levels of 25-D are frequently noted in patients with

autoimmune disease, leading to a current consensus that a deficiency of the

secosteroid may contribute to the autoimmune

KT> disease process. However, Marshall and team explain that these low levels of

25-D are a result, rather than a cause, of the disease process. Indeed,

Marshall's research shows that in autoimmune

KT> disease, 25-D levels are naturally down-regulated in response to VDR

dysregulation by chronic pathogens. Under such circumstances, supplementation

with extra vitamin D is not only

KT> counterproductive but harmful, as it slows the ability of the immune system

to deal with such bacteria.

KT> The team points out the importance of examining alternate models of vitamin

D metabolism.

KT> " Vitamin D is currently being recommended at historically unprecedented

doses, " states Amy Proal, one of the paper's co-authors. " Yet at the same time,

the rate of nearly every autoimmune

KT> disease continues to escalate. "

KT> ###

KT> For the past five years, Autoimmunity Research Foundation has been running

an observational study in which patients are administered pulsed low dose

antibiotics and a VDR agonist in order to

KT> kill chronic bacteria implicated in their diseases. Specific data on the

cohort was recently presented by CAPT H. , USPHS (ret) at the

International Congress on Autoimmunity in Porto,

KT> Portugal:

KT> Transcript:

http://autoimmunityresearch.org/transcripts/ICA2008_Transcript_Tom.pdf

KT> Video: http://vimeo.com/1789735

KT> Resources

KT> Citation: Albert PJ et al. In press. Autoimmunity Reviews. " Vitamin D: The

alternative hypothesis. "

KT> Full-text preprint:

http://autoimmunityresearch.org/transcripts/AR-Albert-VitD.pdf

KT> DOI: http://dx.doi.org/10.1016/j.autrev.2009.02.011

KT> Presentation on clinical data:

KT> Transcript:

http://autoimmunityresearch.org/transcripts/ICA2008_Transcript_Tom.pdf

KT> Video: http://vimeo.com/1789735

KT> Foundation website: http://AutoimmunityResearch.org/

KT> ---------------------------------

KT> Make your Messenger window look the way you want. Express Yourself!

KT>

[Guest guest]

We can easliy get enough Vit D from the sun. 3 times a week for 20 mins

exposing 60% of your body. Gives you ample supply.

Hope that helps

KT

Patilla DaHun <glypella@...> wrote:

Well, they had best come up with a remedy then. Since the heart is

a

muscle, I'm not going to risk a heart attack by not taking extra D.

Barth

---

[Guest guest]

Not easy to do if the weather is freezing, lol! Does make me want to move!

We can easliy get enough Vit D from the sun. 3 times a week for 20 mins

exposing 60% of your body. Gives you ample supply.

Hope that helps

KT