Re: Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experim

[Guest guest]

--- In , LiveSimply <quackadillian@...>

> Quite a few chemotherapy drugs are based on mycotoxins. In fact, the

> strongest trichothecene toxins in stachybotrys were examined as

> possible immunosuppressant drugs but the study was discontinued

> because they were too toxic.

Live,

This is not true. The trichothecene mycotoxin that was used as the

chemotherapeutic agent was diacetoxyscirpenol (DAS or anguidine). It

is obtained from Fusarium sp. not Stachybotrys. As far as I know

Stachy toxins have never been used in medicine.

from the work of Wannemacher (Chapter 34 TRICHOTHECENE MYCOTOXINS):

Chemotherapy: The trichothecenes inhibit cell division causing cell

death. This was used as a basis for chemotherapy drug trial.25-27

Cancer patients were given daily doses (0.077 mg/kg) of DAS

(anguidine) for 5 days. They developed signs and symptoms of toxicity

which included nausea, vomiting, diarrhea, burning erythema,

confusion, ataxia, chills, fever, hypotension and hair loss. 26,27

The antitumor activity was either absent or minimal and the drug

trials were stopped because of patient intolerance.

-Branislav

[Guest guest]

Branislav, you might be right. I thought I originally saw the abstract

on PubMed or jstage..but I definitely remember reading the paper you

mentioned. Its quite possible that I confused the two.

Regardless, THANK YOU