Re: O/T ( Excellent) Understanding and Preventing Feedborne Mycotoxins (Part 1)

[Guest guest]

I found this on the same website.

" Ability to Adsorb Within Thirty Minutes of Feeding. Since most of the

adsorption of mycotoxins takes place in the small intestines before reaching the

gut, it is utmost important that an adsorbent acts rapidly. Any subsequent

adsorption which takes place after the small intestine is of little benefit as a

majority of the consumed mycotoxins would have already been adsorbed into the

blood and have caused damage to organs, immunosuppression, and reproductive

disorders. "

This is probably why so many of us have chronic problems. It's because once the

mycotoxins are adsorbed binders are of little value. They have already been

adsorbed into the blood and have caused damage.

Sharon H.

Mycotoxin contamination is a recurring nightmare that affects grain and grass

crops in the field, in storage and during mixing and delivery. Some toxins tend

to be more prevalent in temperate or tropic climates, but most fungi and

mycotoxins are found throughout the world.

Due to the increase in the global trading of feedstuffs, mycotoxins are no

longer solely found in certain geographical regions but are more widely

distributed than before. At least 25 percent of the world's cereals, according

to the United Nations' Food and Agriculture Organization (FAO), are affected by

mycotoxins.

Mycotoxins affect animals in different ways. Health and reproductive problems

are common; however, poor performance and lost production efficiency are more

frequent and have the greatest economic impact.

To counteract the effects of mycotoxins, nutritional and veterinary companies

have developed and marketed more than 50 mycotoxin binders. But which of these

binders is the most effective, safe, and economical?

Below is the seven-point test that Alltech, Inc. developed to determine the

efficacy, safety, and economy of a mycotoxin binder.

1. Ability to Adsorb a Wide Range of Mycotoxins. An excellent binder is capable

of adsorbing a wide range of mycotoxins, either singly or combinations of

mycotoxins (broad-spectrum).

2. A Low Effective Inclusion Rate. Porosity and a vast surface area (1 gram of

MTB-100=20 m2) allow esterified glucomannan (MTB-100) to be included at low

rates (500 grams-1.0 kg/ton of feed).

3. Stability Over a Wide pH Range. Changes in pH during digestion do not alter

product effectiveness.

4. High Capacity to Adsorb High Concentrations of 1Vlycotoxins. The naturally

high capacity of MTB-100 to adsorb mycotoxins allows the product to adsorb the

greatest amount of mycotoxin when the toxin is present in high concentrations.

5. High Affinity to Adsorb Low Concentrations of Mycotoxins. Mycotoxins often

become diluted in finished feed and can be present in parts per billion (ppb).

Owing to its naturally high affinity for mycotoxins, MTB-100 can specifically

adsorb the greatest amount of these mycotoxins appearing at low concentrations.

Dr. Karl Dawson, director for research of Alltech, Inc., investigated the

adsorptive ability of MTB-100 and other adsorbents over several toxin

concentrations. The results demonstrated that MTB-100 has a greater affinity to

adsorb mycotoxins present in low concentrations and that the product also had a

superior capacity to adsorb when the mycotoxins were present in high

concentrations.

6.Ability to Adsorb Within Thirty Minutes of Feeding. Since most of the

adsorption of mycotoxins takes place in the small intestines before reaching the

gut, it is utmost important that an adsorbent acts rapidly. Any subsequent

adsorption which takes place after the small intestine is of little benefit as a

majority of the consumed mycotoxins would have already been adsorbed into the

blood and have caused damage to organs, immunosuppression, and reproductive

disorders.

Prof. G. Devegowda of University of Bangalore, India, demonstrated the rapid

adsorption of aflatoxin B 1 and T-2 toxin by MTB-100 in a biological system at

different time intervals after ingestion of feed in broiler chickens. He clearly

showed the ability of MTB-100 to rapidly adsorb mycotoxins within 30 minutes of

feeding.

7. Proven In Vivo Data. The last few years have brought an incredible amount of

information about the nature of binders and adsorbents that can be used to

decrease the bioavailability of mycotoxins. Since these fungal toxins are often

effective at low concentrations, it has been necessary to develop new mechanisms

for understanding the basic adsorption processes involved in toxin clearance.

It is clear that simple " binding assays " do not reflect the efficacy of many

adsorbent materials that interact with mycotoxins. In vitro studies are carried

out in strongly abstracted models of the conditions that exist in the digestive

tract of target animal species. Demonstration of the efficacy of any mycotoxin

adsorbent must therefore be clearly shown through in vivo studies.

Mycotoxin Species No. of In Vivo Trials

Vomitoxin (DON) Dairy cattle 1

Aflatoxin Dairy cattle 2

Aflatoxin Ducks 3

Zearalenone and DON Pigs 1

DON Pigs 1

Fusarium toxins Pigs 1

Fusarium toxins Pigs 3

Aflatoxin Poultry 8

Aflatoxin B1 Poultry 2

Aflatoxin,

Ochratoxin and T-2 Poultry 2

T-2 toxin Poultry 2

DAS Poultry 1

Ochratoxin A Poultry 1

Fusarium toxins Poultry 3

http://www.agribusinessweek.com/understanding-and-preventing-feedborne-mycotoxin\

s-part-1/