Acute Renal Failure from Inhalation of Mycotoxins

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Vol. 64, No. 4, 1993

http://www.online.karger.com/ProdukteDB/produkte.asp?Doi=187411

Free Abstract Article (PDF 2398 KB)

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Case Report

Acute Renal Failure from Inhalation of Mycotoxins

N. Di Paoloa, A. Guarnieria, F. Loib, G. Sacchic, A.M. Mangiarottid,

M. Di Paoloa

aNephrology and Dialysis Department, and

bEnvironmental Health Department, Regional Hospital of Siena;

cInstitute of Anatomy, University of Siena;

dInstitute of Medical Mycology, University of Parma, Italy

Address of Corresponding Author

Nephron 1993;64:621-625 (DOI: 10.1159/000187411)

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Key Words

Acute renal failure

Mycotoxin

Ochratoxin

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Abstract

Mysterious deaths of archeologists after opening Egyptian tombs have

been suspected to be secondary to inhalation of mycotoxin, however,

the hypothesis has never been verified. Recently, we observed a case

of acute renal failure (ARF) undeniably due to inhalation of

ochratoxin of Aspergillus ochraceus. After spending 8 h in a granary

which had been closed for several months, a farmer and his wife

suffered temporary respiratory distress; 24 h later, the woman

developed nonoliguric ARF and biopsy revealed tubulonecrosis which

healed in 24 days. Toxic substances were not found, but a strain of

A. ochraceus producing ochratoxin was isolated from the wheat.

Copyright © 1993 S. Karger AG, Basel

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Author Contacts

Prof. Nicola Di Paolo, Nephrology and Dialysis Department, Regional

Hospital of Siena, Piazza Duomo, 2, I-53100 Siena (Italy)

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Article Information

Accepted: October 23, 1992

Published online: December 12, 2008

Number of Print Pages : 5