Re: Re: A safe house is key - Hypersensitivity/MAST cells explained

[Guest guest]

At 10:43 AM 4/18/2009, you wrote:

>As says, mold illness upregulates. Sensitivity to mold toxins

>becomes more and more acute. Tolerance to limited exposure

>decreases. Over time, the need for ever-increasingly pristine living

>arrangements becomes apparent.

The technical term for this is " hypersensitivity " , a medical

term. For 40+ years

it was one of the four types of sensitivity. In the last 10 years, the formal

medical definitions of immediate hypersensitivity has changed from a reaction

within seconds to minutes to outside of 24 hours. I do not agree

with this change.

Briefly, dumping many of the tech terms for those who want to read more,

the cause is the immune system cell mediated response is the MAST cell,

a spherical ball created in the thymus and circulated in the blood stream,

has many receptors on it surface for allergens to activate, which causes

certain shaped tunnels to open going through the MAST cell outer membrane,

and the shaped tunnel allows only certain shaped molecules to be released

into the blood stream. These molecules are active immune system chemicals

to heal the body. When the MAST cell receptors are all activated at the same

time, then all the MAST tunnels open, fully, dumping the entire contains of

the MAST cell into the blood stream. Ouch. That has to hurt. The MAST

receptors will eventually release the bound allergen, slowly, leaving a MAST

cell with just 98% of bound receptors. A second exposure will fill

the last 2%,

and again chemicals will be released.

To be cured of this, all the MAST cell receptors must be unbound, meaning

no exposure to the one or more allergens that cause this condition. This can

take 1 year, or 2 in rare cases. By " no exposures " means exactly that. I

read the longest cure was 10 years (documented).

You can find all this in a SciAm.com special edition on the Immune System.

Good reading, even for the layperson, and lots of pretty diagrams and images.

[Guest guest]

<pete-@...> wrote:

At 10:43 AM 4/18/2009, you wrote:

>As says, mold illness upregulates. Sensitivity to mold toxins

>becomes more and more acute. Tolerance to limited exposure

>decreases. Over time, the need for ever-increasingly pristine living

>arrangements becomes apparent.

The technical term for this is " hypersensitivity " , a medical

term. For 40+ years

it was one of the four types of sensitivity. In the last 10 years, the formal

medical definitions of immediate hypersensitivity has changed from a reaction

within seconds to minutes to outside of 24 hours. I do not agree

with this change.

Briefly, dumping many of the tech terms for those who want to read more,

the cause is the immune system cell mediated response is the MAST cell,

a spherical ball created in the thymus and circulated in the blood stream,

has many receptors on it surface for allergens to activate, which causes

certain shaped tunnels to open going through the MAST cell outer membrane,

and the shaped tunnel allows only certain shaped molecules to be released

into the blood stream. These molecules are active immune system chemicals

to heal the body. When the MAST cell receptors are all activated at the same

time, then all the MAST tunnels open, fully, dumping the entire contains of

the MAST cell into the blood stream. Ouch. That has to hurt. The MAST

receptors will eventually release the bound allergen, slowly, leaving a MAST

cell with just 98% of bound receptors. A second exposure will fill

the last 2%,

and again chemicals will be released.

To be cured of this, all the MAST cell receptors must be unbound, meaning

no exposure to the one or more allergens that cause this condition. This can

take 1 year, or 2 in rare cases. By " no exposures " means exactly that. I

read the longest cure was 10 years (documented).

You can find all this in a SciAm.com special edition on the Immune System.

Good reading, even for the layperson, and lots of pretty diagrams and images.