estradot blood serum study versus estrogel

April 14, 2008

I just read this study that shows that on .5 mg dot your blood serum

is about 50 and on 1 mg dot it is about 100 on post menopausal

women. Mine was 180 on 2 dots. I know that even overdosing on

estrogel that at times mine got low enough to feel warm or awaken in

the night. So, again I like the dots because it is concsistent

steady flow of the estrogen. Here is the study Comparative

bioequivalence studies with Estradot and Menorest transdermal

systems.Hossain M, Quebe-Fehling E, Sergejew T, Schmidt G, Skerjanec

A, Cohen A, Krinsky L, Ibarra de Palacios P.

Novartis Pharma AG, Basel, Switzerland.

OBJECTIVES: To compare the relative bioavailability of Estradot, a

small size, new generation estradiol transdermal system (ETS) to

Menorest, in healthy postmenopausal women. METHODS: In two open-

label, single center, randomized, crossover, bioequivalence studies,

healthy postmenopausal women aged 40-65 years received treatment with

all the test regimens. In Study 1 (single-dose study), patients wore

5 cm(2) (50 microg/day), 10 cm(2) (100 microg/day) Estradot and 29 cm

(2) (100 microg/day) Menorest for 84 h. In Study 2 (multiple-dose

study), patients wore a regimen of four consecutive treatments with a

5 cm(2) (50 microg/day) new generation patch, Estradot and a 14.5 cm

(2) (50 microg/day) patch, Menorest. Blood samples were drawn at

various time-points in both studies. Estradiol and estrone serum

levels were determined by gas chromatography/mass spectrometry or

radioimmunoassay methods. Skin irritation (erythema and edema), patch

adherence and local skin reaction were assessed following patch

removal. RESULTS: In Study 1, baseline-uncorrected C(max) for

estradiol for Estradot 50 and 100 microg/day and Menorest 100

microg/day was 54.8, 106.2 and 101.6 pg/ml, respectively, and C(max)

for estrone was 75.6, 97.0 and 98.3 pg/ml, respectively. In Study 2,

the baseline-uncorrected mean maximum serum concentration (C(max))

for estradiol for Estradot 50 microg/day and Menorest 50 microg/day

patches was 56.7 and 52.7 pg/ml, respectively, and C(max) for estrone

was 41.7 and 41.3 pg/ml, respectively. No significant skin irritation

was observed in either study, but Estradot caused less skin

irritation than Menorest. CONCLUSIONS: Estradot produced comparable

serum concentrations of estradiol and estrone and caused less skin

irritation than Menorest.

PMID: 14585521 [PubMed - indexed for MEDLINE]

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