TOBI & Tobramycin

[Guest guest]

fyi

I found this web site about TOBI/Tobramycin

Does seem that Genta, Tobi and Tobramycin are relatively specific to pathogen, one of which is P aeruginosa (Psa),

Also seems that Tobi is the nebulised from of Tobramycin see last paragraph.

APPROVED NAME: Tobramycin Nebuliser Solution

BRANDNAME: TOBI (Pathogenesis Limited)

PRESENTATION[1]: TOBI is a sterile, clear, slightly yellow, preservative-free, non-pyrogenic, aqueous solution containing 300mg tobramycin/5mL.

THERAPEUTICCLASS: BNF 5.1.4 Aminoglycosides

LICENSEDINDICATIONS [1]: Long-term management of chronic pulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis (CF) patients aged 6 years and older.

DOSE/ADMINISTRATION:

TOBI should be administered over 15 minutes, using a hand-held PARI LC PLUS reusable nebuliser in repeated cycles of 28 days on drug followed by 28 days off drug. It is hoped that intermittent administration will allow bacteria that become resistant to tobramycin to regain sensitivity. Patients should inhale TOBI, 300mg twice daily (as close as possible to 12 hours) during the 28 day on drug period regardless of age or weight. Suitable compressors are those which, when attached to a PARI LC PLUS nebuliser, deliver a flow rate of 4- 6L/min and/or a back pressure of 110-217 kPa.

THERAPEUTIC COMMENT

TOBI for inhalation is a new formulation of tobramycin which is preservative-free. This is an advantage over nebulised intravenous formulations of tobramycin in terms of airway tolerability. Trials comparing TOBI with nebulised colistin are required before place in therapy can be recommended.

http://www.ukmi.nhs.uk/NewMaterial/html/docs/tobramyc.pdf (above),

and

http://www.vitacost.com/Healthnotes/Drug/Tobramycin.aspx – discusses Gentamicin/Tobra etc

Cheers,

joy