Re: Need help on using antipsychotic drug called Leporex (Clozaril in the US)

[Guest guest]

Hi All,

 

Sorry for the confusion - Just realised it is called Clozaril (generic name -

clozapine) in the US. Brand name is Leporex in Europe.

 

Thanks

 

Selma

> From: rriddle_travel <rriddle@stanfordalu mni.org>

> Subject: Re: Need help on using antipsychotic drug called

Laporex

> To: LBDcaregivers@ yahoogroups. com

> Date: Wednesday, July 30, 2008, 9:17 PM

> I have never heard of Laporex. Can you get the generic

> name? Are

> you in the US?

>

>

>

> >

> >

> > Hi All,

> >  

> > My mother has LBD and is in stage 3 or 4. She was

> doing very well

> until 2 months ago although she always had hallucinations

> &

> dellusion. However they were all manageable. Now she has

> started to

> be very aggressive and couldnt recognise her home at all

> and want to

> go home all time - usual sowndowning sendrome.

> >  

> > We have tried Serequal before and it didnt help her at

> all. It made

> her more aggresive. Doctor put her on Laporex, but she is

> not doing

> well with this medicine as well IMHO.

> >  

> > Her career who started working only a month ago (so it

> could be

> that they couldnt get used to each other) is having a hard

> time to

> calm her down. They have to leave home in the afternoon

> and they

> return when my mother get tired of trying to find her

> home.

> >  

> > My question is regarding Laporex. Has anyone any

> experience with

> this drug?

> >  

> > She started with 1/4 lunch time and 1/4 in the

> evening. But since

> that dose did not really help her aggresive behavior doctor

> increased

> the dose. Currently my mother is taking 1/4 in the morning,

> 1/2 lunch

> time and 1/2 in the evening. Doctor is going to increase

> the dose but

> I am not sure this medicine is working. I think it is

> making her more

> aggresive and confused. Or may be she is not on the right

> dose, not

> sure. I am just worried that she will be even more

> aggresive if the

> dose is increased.

> >  

> > Many thanks for your time.

> >  

> > Selma

> >  

> >

>

>

> ------------ --------- --------- ------

>

> Welcome to LBDcaregivers.

>

>

[Guest guest]

Clozapine (Clozaril) is the only antipsychotic that has a lot of good

data behind it (randomized, controlled trials). According to most

medical articles I've read, it's the preferred antipsychotic.

However, because there's a risk of agranulocytosis, weekly blood

draws are required in the first several months of treatment.

Because of this, most neurologists prefer to use quetiapine

(Seroquel). There's a lot of anecdotal data about quetiapine but the

studies haven't all come out favorably.

We do have one person in our local support group who used Clozaril.

Most use Seroquel.

> > >

> > >

> > > Hi All,

> > >  

> > > My mother has LBD and is in stage 3 or 4. She was

> > doing very well

> > until 2 months ago although she always had hallucinations

> > &

> > dellusion. However they were all manageable. Now she has

> > started to

> > be very aggressive and couldnt recognise her home at all

> > and want to

> > go home all time - usual sowndowning sendrome.

> > >  

> > > We have tried Serequal before and it didnt help her at

> > all. It made

> > her more aggresive. Doctor put her on Laporex, but she is

> > not doing

> > well with this medicine as well IMHO.

> > >  

> > > Her career who started working only a month ago (so it

> > could be

> > that they couldnt get used to each other) is having a hard

> > time to

> > calm her down. They have to leave home in the afternoon

> > and they

> > return when my mother get tired of trying to find her

> > home.

> > >  

> > > My question is regarding Laporex. Has anyone any

> > experience with

> > this drug?

> > >  

> > > She started with 1/4 lunch time and 1/4 in the

> > evening. But since

> > that dose did not really help her aggresive behavior doctor

> > increased

> > the dose. Currently my mother is taking 1/4 in the morning,

> > 1/2 lunch

> > time and 1/2 in the evening. Doctor is going to increase

> > the dose but

> > I am not sure this medicine is working. I think it is

> > making her more

> > aggresive and confused. Or may be she is not on the right

> > dose, not

> > sure. I am just worried that she will be even more

> > aggresive if the

> > dose is increased.

> > >  

> > > Many thanks for your time.

> > >  

> > > Selma

> > >  

> > >

> >

> >

> > ------------ --------- --------- ------

> >

> > Welcome to LBDcaregivers.

> >

> >

[Guest guest]

Clozapine (Clozaril) is the only antipsychotic that has a lot of good

data behind it (randomized, controlled trials). According to most

medical articles I've read, it's the preferred antipsychotic.

However, because there's a risk of agranulocytosis, weekly blood

draws are required in the first several months of treatment.

Because of this, most neurologists prefer to use quetiapine

(Seroquel). There's a lot of anecdotal data about quetiapine but the

studies haven't all come out favorably.

We do have one person in our local support group who used Clozaril.

Most use Seroquel.

> > >

> > >

> > > Hi All,

> > >  

> > > My mother has LBD and is in stage 3 or 4. She was

> > doing very well

> > until 2 months ago although she always had hallucinations

> > &

> > dellusion. However they were all manageable. Now she has

> > started to

> > be very aggressive and couldnt recognise her home at all

> > and want to

> > go home all time - usual sowndowning sendrome.

> > >  

> > > We have tried Serequal before and it didnt help her at

> > all. It made

> > her more aggresive. Doctor put her on Laporex, but she is

> > not doing

> > well with this medicine as well IMHO.

> > >  

> > > Her career who started working only a month ago (so it

> > could be

> > that they couldnt get used to each other) is having a hard

> > time to

> > calm her down. They have to leave home in the afternoon

> > and they

> > return when my mother get tired of trying to find her

> > home.

> > >  

> > > My question is regarding Laporex. Has anyone any

> > experience with

> > this drug?

> > >  

> > > She started with 1/4 lunch time and 1/4 in the

> > evening. But since

> > that dose did not really help her aggresive behavior doctor

> > increased

> > the dose. Currently my mother is taking 1/4 in the morning,

> > 1/2 lunch

> > time and 1/2 in the evening. Doctor is going to increase

> > the dose but

> > I am not sure this medicine is working. I think it is

> > making her more

> > aggresive and confused. Or may be she is not on the right

> > dose, not

> > sure. I am just worried that she will be even more

> > aggresive if the

> > dose is increased.

> > >  

> > > Many thanks for your time.

> > >  

> > > Selma

> > >  

> > >

> >

> >

> > ------------ --------- --------- ------

> >

> > Welcome to LBDcaregivers.

> >

> >

[Guest guest]

Sherry.

You are right on the money! We can't assume these will work for anyone with

LBD.

Hugs,

Donna R

Caregave for Mom (after I brought her from WI to MI) for 3 years and 4th year in

a nh.

She was almost 89 when she died in '02. No dx other than mine.

Re: Re: Need help on using antipsychotic drug called

Leporex (Clozaril in the US)

Just a question, were any of those trials and tests performed on LBDers?

I'm just wondering if we can apply those results to people for whom so many

of these kinds of meds have extreme or atypical responses. It seems that

drugs that work well in the general population it can't be assumed that we'd

get the same results in our LO's...in fact we can assume that they won't or

could actually cause harm. That's my only concern with statements based on

tests and trials unless they're performed on LBDers.

Is there any validity to my thoughts?

His,

Sherry

www.owly.net

daughter of , (mis?)diagnosed with AD in 2005, descent slowed by

Aricept; diagnosed with LBD March 2008, in a wonderful NH 1/2 mile from my

house. We're learning to live with Lewy...

----- Original Message -----

Clozapine (Clozaril) is the only antipsychotic that has a lot of good

data behind it (randomized, controlled trials). According to most

medical articles I've read, it's the preferred antipsychotic.

However, because there's a risk of agranulocytosis, weekly blood

draws are required in the first several months of treatment.

[Guest guest]

Yes, some of the studies are in those with LBD.

But, when it comes to meds, you *always* have proceed cautiously in

those with LBD (or any neurodegenerative disorder) or the elderly.

>

> Just a question, were any of those trials and tests performed on

LBDers?

> I'm just wondering if we can apply those results to people for whom

so many

> of these kinds of meds have extreme or atypical responses. It

seems that

> drugs that work well in the general population it can't be assumed

that we'd

> get the same results in our LO's...in fact we can assume that they

won't or

> could actually cause harm. That's my only concern with statements

based on

> tests and trials unless they're performed on LBDers.

>

> Is there any validity to my thoughts?

>

> His,

> Sherry

> www.owly.net

> daughter of , (mis?)diagnosed with AD in 2005, descent slowed

by

> Aricept; diagnosed with LBD March 2008, in a wonderful NH 1/2 mile

from my

> house. We're learning to live with Lewy...

>

>

> ----- Original Message -----

>

> Clozapine (Clozaril) is the only antipsychotic that has a lot of

good

> data behind it (randomized, controlled trials). According to most

> medical articles I've read, it's the preferred antipsychotic.

> However, because there's a risk of agranulocytosis, weekly blood

> draws are required in the first several months of treatment.

>

[Guest guest]

Many thanks for your all responses. Although her doctor wasnt really insist on

weekly blood test but I will get it done just to be on the safe side.

 

I am really hoping that it will work for my mum as all other antipsychotics are

failed to calm her down.

 

Regards

Selma

 

Subject: Re: Need help on using antipsychotic drug called

Leporex (Clozaril in the US)

To: LBDcaregivers

Date: Thursday, July 31, 2008, 12:26 PM

Yes, some of the studies are in those with LBD.

But, when it comes to meds, you *always* have proceed cautiously in

those with LBD (or any neurodegenerative disorder) or the elderly.

>

> Just a question, were any of those trials and tests performed on

LBDers?

> I'm just wondering if we can apply those results to people for whom

so many

> of these kinds of meds have extreme or atypical responses. It

seems that

> drugs that work well in the general population it can't be assumed

that we'd

> get the same results in our LO's...in fact we can assume that they

won't or

> could actually cause harm. That's my only concern with statements

based on

> tests and trials unless they're performed on LBDers.

>

> Is there any validity to my thoughts?

>

> His,

> Sherry

> www.owly.net

> daughter of , (mis?)diagnosed with AD in 2005, descent slowed

by

> Aricept; diagnosed with LBD March 2008, in a wonderful NH 1/2 mile

from my

> house. We're learning to live with Lewy...

>

>

> ----- Original Message -----

> From: " rriddle_travel " <rriddle@... >

> Clozapine (Clozaril) is the only antipsychotic that has a lot of

good

> data behind it (randomized, controlled trials). According to most

> medical articles I've read, it's the preferred antipsychotic.

> However, because there's a risk of agranulocytosis, weekly blood

> draws are required in the first several months of treatment.

>