complex case

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Dear All,I am struggling to make any progress with a particular patient and would appreciate your insights:54 year old female who developed ME like symptoms following a foot operation 6 years ago (the operation was a disaster and she is in constant pain), on top of that she was diagnosed with Hashimoto's 2 years ago and is on 25mg thyroxine (which seems to be very low? anyway, it has made no difference to her symptoms). Her symptoms are: extreme anxiety, which does not respond to the usual herbals, "heat in the head", sore, dry eyes with extreme floaters and some distortion of vision, muscle weakness, and what the patient calls "adrenalin rushes" but could be hot

flushes (periods stopped 3 years ago), generally feeling depressed and despairing, nausea in the morning, poor sleep. She is worse on any exercise. Her blood tests are unremarkable except for low eosinophils; cortisol test showed high cortisol in the morning (chronic pain?). She is on paleo diet, takes vit D3.I have tried so far (in various combinations):Glycyrhiza, Leonorus, Hypericum, Eleuthro, Lavandula, Ribes nigrum, Filipendula, Uncaria, Borago, Valeriana, Passiflora, Salvia, Dioscorea, Tarax rad, Tabebuia, Artemisia annua, Rehmania. She says she is not better and her anxiety is getting worse but wants to keep on trying as she responded well to herbs in the past. It has been suggested to her by a doctor (whom she saw privately and who is a specialist in ME) that she should increase her thyroxine to 75mg/day and take supplement of DHEA of 10mg/day - however, she is not keen to do either.I would be grateful for your collective wisdom.Best wishes