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My mother has offered to connect offlist with other women who are

near her age or over, using BHRT or thinking about using BHRT. She

is 70 and dayum! ...she is amazing. My legs burn trying to keep up

with her on a ski hill - she's a crazy speed demon.

Mom now uses a full range of BHRT which she tailors specifically for

her body. She did the WP and whoa she has no sympathy for anyone

getting on it now, given that there is so much information out there

about what a disaster it is for some of us. There was nothing

negative when we went on it. The WP was a disaster for her - really

scary!!! Her immune system was slammed and her lungs took a terrible

hit. Sadly she was dealing with that when her own mother died. Why

did she stick with it after starting it? Like so many of us, that

estrogen was so amazing.... we wanted to figure out how to make it

work and we were told that it was dangerous to use all that E without

using all the P (!!! Wiley strongly implied we could get cancer), but

now she gets her estrogen without all the hell simply by designing

her own program.

In her 50's she developed osteoporosis and eventually went on

Fosomax. My anti aging doc doesn't like the stuff as he thinks it

ages women so Mom got off it when she got on hormones, but she was

worried about her bones given how much she likes to ski. It appears

that her BHRT and a regular exercise program has solved the

problem. She's also found a huge improvement from a lifetime of

migraines and a wheat allergy since being on estrogen.

At this point she likes using Estraderm patches (50's) and uses two

at a time putting them on different days. If I recall correctly

she's come to prefer using oral Prometrium for a stretch of days to

trigger a bleed and finds she tolerates it better. I'll see if it's

changed.... her program changes and evolves as she listens to her

body and tries other things. She says she likes the Estraderm

patches as she can see when they are used up. With E she is biking

up the mountain. Without E.... oh no.... don't even go there.

She is a fantastic example of someone fearlessly experimenting and

listening to her body to successfully design her own program. So, if

you are in the older crowd and want to connect with her, let me know.

Laurel

** BTW, Dr. Formby pointed out that there is no science to support

that estrogen is a carcinogen. He also pointed out that the idea of

prophylactic use of progesterone to supposedly avoid cancer has no

place in BHRT.

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The more I read the studies about breast cancer the more I see P involved Here

is one that

includes the BRAC1 gene. Thought it was interesting because taking additional P

if you

have this gene might not be so healthy.

Karin (bigbird)

Comment in:

Science. 2006 Dec 1;314(5804):1370.

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone

antagonist.

Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY.

Department of Biological Chemistry, University of California, Irvine, CA

92697-4037, USA.

Women with mutations in the breast cancer susceptibility gene BRCA1 are

predisposed to

breast and ovarian cancers. Why the BRCA1 protein suppresses tumor development

specifically in ovarian hormone-sensitive tissues remains unclear. We

demonstrate that

mammary glands of nulliparous Brca1/p53-deficient mice accumulate lateral

branches

and undergo extensive alveologenesis, a phenotype that occurs only during

pregnancy in

wild-type mice. Progesterone receptors, but not estrogen receptors, are

overexpressed in

the mutant mammary epithelial cells because of a defect in their degradation by

the

proteasome pathway. Treatment of Brca1/p53-deficient mice with the progesterone

antagonist mifepristone (RU 486) prevented mammary tumorigenesis. These findings

reveal a tissue-specific function for the BRCA1 protein and raise the

possibility that

antiprogesterone treatment may be useful for breast cancer prevention in

individuals with

BRCA1 mutations.

PMID: 17138902 [PubMed - indexed for MEDLINE]

Related Articles

>

> My mother has offered to connect offlist with other women who are

> near her age or over, using BHRT or thinking about using BHRT. She

> is 70 and dayum! ...she is amazing. My legs burn trying to keep up

> with her on a ski hill - she's a crazy speed demon.

>

> Mom now uses a full range of BHRT which she tailors specifically for

> her body. She did the WP and whoa she has no sympathy for anyone

> getting on it now, given that there is so much information out there

> about what a disaster it is for some of us. There was nothing

> negative when we went on it. The WP was a disaster for her - really

> scary!!! Her immune system was slammed and her lungs took a terrible

> hit. Sadly she was dealing with that when her own mother died. Why

> did she stick with it after starting it? Like so many of us, that

> estrogen was so amazing.... we wanted to figure out how to make it

> work and we were told that it was dangerous to use all that E without

> using all the P (!!! Wiley strongly implied we could get cancer), but

> now she gets her estrogen without all the hell simply by designing

> her own program.

>

> In her 50's she developed osteoporosis and eventually went on

> Fosomax. My anti aging doc doesn't like the stuff as he thinks it

> ages women so Mom got off it when she got on hormones, but she was

> worried about her bones given how much she likes to ski. It appears

> that her BHRT and a regular exercise program has solved the

> problem. She's also found a huge improvement from a lifetime of

> migraines and a wheat allergy since being on estrogen.

>

> At this point she likes using Estraderm patches (50's) and uses two

> at a time putting them on different days. If I recall correctly

> she's come to prefer using oral Prometrium for a stretch of days to

> trigger a bleed and finds she tolerates it better. I'll see if it's

> changed.... her program changes and evolves as she listens to her

> body and tries other things. She says she likes the Estraderm

> patches as she can see when they are used up. With E she is biking

> up the mountain. Without E.... oh no.... don't even go there.

>

> She is a fantastic example of someone fearlessly experimenting and

> listening to her body to successfully design her own program. So, if

> you are in the older crowd and want to connect with her, let me know.

>

> Laurel

>

> ** BTW, Dr. Formby pointed out that there is no science to support

> that estrogen is a carcinogen. He also pointed out that the idea of

> prophylactic use of progesterone to supposedly avoid cancer has no

> place in BHRT.

>

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