Re: Arimidex and Hypericum

[Guest guest]

Think it is a tough call, cause although Jonathon doesn't mention it

specifically, I guess the theoretical interaction is that it will metabolise it

faster. As likely the interaction will be more complex, (in many circumstance

consider it a possible advantage as opposed to a problem), but you may want to

be cautious in this instance. In the sense you cannot monitor and undo. A thing

to consider is how might the hypericum be helping exactly - is it MAO (unlikely

as the activity seems marginal , and I always think the least significant

action), in which case passiflora might take the edge off. Is it by supporting

adn clearing things through the liver - in which case you are a bit stuck, but

you could at least focus on energy side by focussing on adrenals( I am really

llikeing Rhodolia for cheering up at the moment - though haven't considered

interactions in this particular case) - especially cause of airside side

effects.Also you can approach sugar level dips from a different direction. Has

she a propensity towards SAD - vitamin D supplements. Physical nerve

transmission - fish oils. Etc. A herbalist has many tools, which is one of the

things so fantastic about us!

Good luck,

Arimidex and Hypericum

Hello everyone, I could do with a very quick response to this query if

possible as patient coming this afternoon to collect Rx. Her first consultation

was yesterday, 40 years old, dx with oestrogen and Her 2 neu positive, grade II

breast cancer last year. Lumpectomy and lymph nodes removed, followed by 6x

epirubicin and cyclophosamide, plus 20 sessions of radiotherapy. Was prescribed

17 IV infusions of herceptin but as heart function deteriorated after 5 she

elected to stop (consultant told her that recent research showed that women

taking 5 lots of herceptin in trials did as well as those having the full

17).Became menopausal following chemo, elected to have both ovaries removed June

08.Taking Arimidex. Now doing really well, changing her life and diet,

addressing lots of emotional issues from the past. Had a recent stay in

Australia and saw naturopath/herbalist who prescribed her a herbal tincture

which has really improved her joint stiffness and most i! mportantly, her mood.

This mixture contains Hypericum and I am wondering about its impact on the

metabolism of Arimidex. I have checked my most up to date interactions book

(Jonathon Treasure's) and he doesn't mention a problem with Arimidex/Hypericum

but I wanted to get other practitioners thoughts on this. This is my main query

- this mix has clearly made a really positive impact on this patients mood and

this is really important to her at the current time.

The mixture also contains Trifolium and I'm wondering about that too -

especially in the light of Chanchal's recent 3 day seminar series when she said

that the effect of phyto oestrogen containing plants in post menopausal women

with oestrogen receptive cancers problematic and, as I remember, she didn't give

them.

All thougths much appreciated.

Regards

Sue Salmon

Huddersfield

[Guest guest]

There's some info on Rxlist.com - part of it here:

http://www.rxlist.com/arimidex-drug.htm

Arimidex is mostly metabolised by the liver (85%) and inhibits reactions

catalysed by some sub-species of P450 (never realised there were so many

varieties!). It seems that drug-drug reactions are not a big issue.

Hypericum needs caution with drugs that have a narrow therapeutic window, and

looking at dosages for Arimidex, it doesn't look like Arimidex is one of those.

Helen

Arimidex and Hypericum

Hello everyone, I could do with a very quick response to this query if

possible as patient coming this afternoon to collect Rx. Her first consultation

was yesterday, 40 years old, dx with oestrogen and Her 2 neu positive, grade II

breast cancer last year. Lumpectomy and lymph nodes removed, followed by 6x

epirubicin and cyclophosamide, plus 20 sessions of radiotherapy. Was prescribed

17 IV infusions of herceptin but as heart function deteriorated after 5 she

elected to stop (consultant told her that recent research showed that women

taking 5 lots of herceptin in trials did as well as those having the full

17).Became menopausal following chemo, elected to have both ovaries removed June

08.Taking Arimidex. Now doing really well, changing her life and diet,

addressing lots of emotional issues from the past. Had a recent stay in

Australia and saw naturopath/herbalist who prescribed her a herbal tincture

which has really improved her joint stiffness and most importantly, her mood.

This mixture contains Hypericum and I am wondering about its impact on the

metabolism of Arimidex. I have checked my most up to date interactions book

(Jonathon Treasure's) and he doesn't mention a problem with Arimidex/Hypericum

but I wanted to get other practitioners thoughts on this. This is my main query

- this mix has clearly made a really positive impact on this patients mood and

this is really important to her at the current time.

The mixture also contains Trifolium and I'm wondering about that too -

especially in the light of Chanchal's recent 3 day seminar series when she said

that the effect of phyto oestrogen containing plants in post menopausal women

with oestrogen receptive cancers problematic and, as I remember, she didn't give

them.

All thougths much appreciated.

Regards

Sue Salmon

Huddersfield

[Guest guest]

Hi all,

Anastrozole is a potent inhibitor of CYP19 ( = aromatase). It also inhibits 1A2,

2C9 and

3A4.

In my opinion, the 3rd generation AIs are way less specific than CYP19

inhibitors and

women taking them can display a bewildering if subtle variety of side effects

due to non

specific inhibition of enzymes with related prosthetic structure, not just the

CYP

superfamily, but eg SOD etc Depression is very common , but under-reported in

the

literature. Changing the AI can sometimes help tolerability.

" theoretically " SJW might influence clearance of the drug but who knows, We tend

to look

at a full estrogen panel in these patients ( before and efter the drug) to see

how effective

the inhibition of peripheral aromatisation is. To be honest, herbal and natural

strategies

are on a par with AI's in this respect but way more inconvenient and

expensive. Usually

disposable income in these patients is 'better spent " on other strategic angles

as it were.

I see no problem with isoflavones in post menopausal ER+ patients, indeed,

genistein is an

" aromatase inhibitor " . Of course, it all depends on the whole approach.

happpy holidays

jonathan ( snow locked in Oregon)

> Arimidex is mostly metabolised by the liver (85%) and inhibits reactions

catalysed by

some sub-species of P450 (never realised there were so many varieties!). It

seems that

drug-drug reactions are not a big issue.

>

> Hypericum needs caution with drugs that have a narrow therapeutic window, and

looking at dosages for Arimidex, it doesn't look like Arimidex is one of those.

>

> Helen

>

>

> Arimidex and Hypericum

>

>

> Hello everyone, I could do with a very quick response to this query if

possible as

patient coming this afternoon to collect Rx. Her first consultation was

yesterday, 40 years

old, dx with oestrogen and Her 2 neu positive, grade II breast cancer last year.

Lumpectomy and lymph nodes removed, followed by 6x epirubicin and

cyclophosamide,

plus 20 sessions of radiotherapy. Was prescribed 17 IV infusions of herceptin

but as heart

function deteriorated after 5 she elected to stop (consultant told her that

recent research

showed that women taking 5 lots of herceptin in trials did as well as those

having the full

17).Became menopausal following chemo, elected to have both ovaries removed June

08.Taking Arimidex. Now doing really well, changing her life and diet,

addressing lots of

emotional issues from the past. Had a recent stay in Australia and saw

naturopath/herbalist who prescribed her a herbal tincture which has really

improved her

joint stiffness and most importantly, her mood. This mixture contains Hypericum

and I am

wondering about its impact on the metabolism of Arimidex. I have checked my most

up to

date interactions book (Jonathon Treasure's) and he doesn't mention a problem

with

Arimidex/Hypericum but I wanted to get other practitioners thoughts on this.

This is my

main query - this mix has clearly made a really positive impact on this patients

mood and

this is really important to her at the current time.

>