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RE: Stem cell

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Laurie,You can hunt down Dr. Cheryl . She used to work at Arboretum View Animal Hospital in IL and has relocated to CO somewhere. She did research for a companion animal stem cell company and has performed the procedure on many patients. She may have some advice for you.Best, Mayer DVM CVA CVC CCRPIntegrative VeterinarianFounder and CEOwww.integrativeveterinarian.com From: VetRehab [mailto:VetRehab ] On Behalf Of Dr. Laurie McCauleySent: Saturday, May 19, 2012 4:15 PMTo: VetRehab Subject: Stem cell I have an 9 month old agility dog that just had sx for FCP and a bone spur at the elbow. Coronoid process was dropped and was unable to be recovered. 7 days later she is still non wt bearing and painful if you ask her to put wt on the limb. Owner asked me about stem cell therapy. Is anyone using this for young dogs? If so, what are your results?Laurie McCauley, DVMSent from my iPhone

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Hi Laurie,

What do you mean the coronoid was dropped and couldn't be recovered?

The objective is to remove it. Was it left in the joint? I have used

stem cell therapy a couple of times. Once on my own lab. She had

bilateral elbow arthroscopy for FCP removal at one year of age when I

adopted her and she was lame for 5 months. That was with appropriate

surgical recovery. I used Vet-Stem adipose derived stem cell therapy

(a misnomer of course, it is really a stromal vascular fraction) but

anyway one month after therapy her lameness resolved. I also did a

second young lab with severe DJD secondary to OCD of the medial aspect

of the humeral condyle and FCP. His response was more difficult to

fully evaluate because he got his stem cells 2 days post arthroscopy

so it is hard to say if his improvement was from the removal of the

coronoids and curettage of the OCD or from the stem cell therapy. I

would find out if the coronoid is still in the joint. Maybe she is

non weight bearing because it is in a weight bearing portion of the

joint. If that is the case she needs someone to scope that joint to

get it out. If the coronoid is out I would make sure she is on

appropriate pain medications and give her a little more time.

Although non-weight bearing is certainly not typical post FCP removal.

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Laurie,

The FCP must be removed….think of this like a " pebble in the shoe " , only in this

case a tightly articulated joint. It is a biomechanical discomfort at this

point, no level of PT, NSAIDs or even stem cells is going to help until its

removed (they will help decrease inflammation and pain but not " resolve the

issue " ). If the fragment migrated laterally (assuming it was a medial approach)

they can drop a scope in the lateral compartment to retrieve. Following that,

you should see a favorable response to PT and medical management.

Regarding stem cells for intra-articular pathology (ie., OA) we have not been

impressed with the results long term. The previous clinical trial we performed

for elbow OA using cultured adipose derived progenitor cells combined with PRP

showed clinical improvement for 6-9 months on objective gait analysis. Second

look arthroscopy however, showed no improvement in joint pathology

(another-words stem cell therapy does NOT regenerate the joint). What we do

believe is that is decreases the inflammatory mediators within the joint (this

is part of our current research project). So for OA, it acts in a similar

fashion to HA or even cortisone however way more expensive.

Where we are impressed with regenerative medicine is for the treatment of soft

tissue injury (tendons and ligaments). Here we have found true " regeneration "

or healing based on follow up MRI and musculoskeletal ultrasound. We presented

our data at VA3 in Naples and will be presenting again at the upcoming ACVS /

ACVSMR symposium this fall.

Please let me know if you know the surgeons who performed the original scope, I

would be more than happy to talk with them and walk them through a lateral

portal if they have any questions/concerns……its a bit trickier than a medial

portal.

Best,

Sherman

Sherman O. Canapp Jr., DVM, MS, CCRT

Diplomate, American College of Veterinary Surgeons

Diplomate, American College of Veterinary Sports Medicine & Rehabilitation

Chief of Staff

Veterinary Orthopedic &

Sports Medicine Group

10975 Guilford Road

polis Junction, MD 20701

Phone:

Fax:

http://www.vosm.com

>

> I have an 9 month old agility dog that just had sx for FCP and a bone spur at

the elbow. Coronoid process was dropped and was unable to be recovered. 7 days

later she is still non wt bearing and painful if you ask her to put wt on the

limb. Owner asked me about stem cell therapy. Is anyone using this for young

dogs? If so, what are your results?

> Laurie McCauley, DVM

>

> Sent from my iPhone

>

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