Guest guest Posted October 26, 1999 Report Share Posted October 26, 1999 Lynn, When I did my poll of the major symptoms of PSC pain was number one. Severe fatigue and UC tied for number two. Hugs, Biddy Common denominator >Just interested in your thoughts.....If UC isn't always the common link to >PSC...what could be? What do those without UC have in common with the other >PSC patients? > >Food for thought > >Lynn > > >------------------------------------------------------------------------ >Get A 0% Intro APR Visa with Instant Approval right now a >GetSmart.com at http://clickhere./click/1270 > > > >eGroups.com home: /group/ > - Simplifying group communications > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 26, 1999 Report Share Posted October 26, 1999 Lynn, When I did my poll of the major symptoms of PSC pain was number one. Severe fatigue and UC tied for number two. Hugs, Biddy Common denominator >Just interested in your thoughts.....If UC isn't always the common link to >PSC...what could be? What do those without UC have in common with the other >PSC patients? > >Food for thought > >Lynn > > >------------------------------------------------------------------------ >Get A 0% Intro APR Visa with Instant Approval right now a >GetSmart.com at http://clickhere./click/1270 > > > >eGroups.com home: /group/ > - Simplifying group communications > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 26, 1999 Report Share Posted October 26, 1999 Lynn, When I did my poll of the major symptoms of PSC pain was number one. Severe fatigue and UC tied for number two. Hugs, Biddy Common denominator >Just interested in your thoughts.....If UC isn't always the common link to >PSC...what could be? What do those without UC have in common with the other >PSC patients? > >Food for thought > >Lynn > > >------------------------------------------------------------------------ >Get A 0% Intro APR Visa with Instant Approval right now a >GetSmart.com at http://clickhere./click/1270 > > > >eGroups.com home: /group/ > - Simplifying group communications > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 Biddy........ I realize these things. What I guess I'm asking is what did we have in common prior to being diagnosed.....life style, type of work we did, the area of the country, maybe childhood illness, etc. Maybe I'm crazy and maybe its all genetics at play..but I thought it might be a shot in the dark. Lynn Common denominator > > >>Just interested in your thoughts.....If UC isn't always the common link to >>PSC...what could be? What do those without UC have in common with the >other >>PSC patients? >> >>Food for thought >> >>Lynn >> >> >>------------------------------------------------------------------------ >>Get A 0% Intro APR Visa with Instant Approval right now a >>GetSmart.com at http://clickhere./click/1270 >> >> >> >>eGroups.com home: /group/ >> - Simplifying group communications >> >> >> >> >> > > >------------------------------------------------------------------------ >Essential Feynman Library for $7.99! A $96.65 >value of 3 books+6 audio tape set. Learn >physics from Feynman renown for making >complex ideas easy. Order NOW at Library >of Science http://clickhere./click/1370 > > >eGroups.com home: /group/ > - Simplifying group communications > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 Biddy........ I realize these things. What I guess I'm asking is what did we have in common prior to being diagnosed.....life style, type of work we did, the area of the country, maybe childhood illness, etc. Maybe I'm crazy and maybe its all genetics at play..but I thought it might be a shot in the dark. Lynn Common denominator > > >>Just interested in your thoughts.....If UC isn't always the common link to >>PSC...what could be? What do those without UC have in common with the >other >>PSC patients? >> >>Food for thought >> >>Lynn >> >> >>------------------------------------------------------------------------ >>Get A 0% Intro APR Visa with Instant Approval right now a >>GetSmart.com at http://clickhere./click/1270 >> >> >> >>eGroups.com home: /group/ >> - Simplifying group communications >> >> >> >> >> > > >------------------------------------------------------------------------ >Essential Feynman Library for $7.99! A $96.65 >value of 3 books+6 audio tape set. Learn >physics from Feynman renown for making >complex ideas easy. Order NOW at Library >of Science http://clickhere./click/1370 > > >eGroups.com home: /group/ > - Simplifying group communications > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 Biddy........ I realize these things. What I guess I'm asking is what did we have in common prior to being diagnosed.....life style, type of work we did, the area of the country, maybe childhood illness, etc. Maybe I'm crazy and maybe its all genetics at play..but I thought it might be a shot in the dark. Lynn Common denominator > > >>Just interested in your thoughts.....If UC isn't always the common link to >>PSC...what could be? What do those without UC have in common with the >other >>PSC patients? >> >>Food for thought >> >>Lynn >> >> >>------------------------------------------------------------------------ >>Get A 0% Intro APR Visa with Instant Approval right now a >>GetSmart.com at http://clickhere./click/1270 >> >> >> >>eGroups.com home: /group/ >> - Simplifying group communications >> >> >> >> >> > > >------------------------------------------------------------------------ >Essential Feynman Library for $7.99! A $96.65 >value of 3 books+6 audio tape set. Learn >physics from Feynman renown for making >complex ideas easy. Order NOW at Library >of Science http://clickhere./click/1370 > > >eGroups.com home: /group/ > - Simplifying group communications > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 Hi! The number one common denominator was chemicals -- from working in a chemical plant, to Agent Orange to common household chemicals. There were some who listed autonuclear antibodies -- believe it or not these are the only two that were mentioned. There has to be more. I asked that everyone really think about anything in their past that they would have been subject to or any disease (no matter what) they may have had. I asked whether or not any member or their family had had the same symptoms -- long ago that would help with the genetics thing. That is the only thing I received. They listed all of their symptoms now, but not in the past -- or anything that they were exposed to. I thought if we could get this info together we could help our doctors since they know nothing about us. Hugs, Biddy Common denominator >> >> >>>Just interested in your thoughts.....If UC isn't always the common link to >>>PSC...what could be? What do those without UC have in common with the >>other >>>PSC patients? >>> >>>Food for thought >>> >>>Lynn >>> >>> >>>------------------------------------------------------------------------ >>>Get A 0% Intro APR Visa with Instant Approval right now a >>>GetSmart.com at http://clickhere./click/1270 >>> >>> >>> >>>eGroups.com home: /group/ >>> - Simplifying group communications >>> >>> >>> >>> >>> >> >> >>------------------------------------------------------------------------ >>Essential Feynman Library for $7.99! A $96.65 >>value of 3 books+6 audio tape set. Learn >>physics from Feynman renown for making >>complex ideas easy. Order NOW at Library >>of Science http://clickhere./click/1370 >> >> >>eGroups.com home: /group/ >> - Simplifying group communications >> >> >> >> > > >------------------------------------------------------------------------ >The Mental Health Practitioner’s Instant Resource >Library for $5.99! A 4-book set of time-saving >aids for clinical tasks - a $139.35 value >Join the book club NOW at >http://clickhere./click/1371 > > > >eGroups.com home: /group/ > - Simplifying group communications > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 Hi! The number one common denominator was chemicals -- from working in a chemical plant, to Agent Orange to common household chemicals. There were some who listed autonuclear antibodies -- believe it or not these are the only two that were mentioned. There has to be more. I asked that everyone really think about anything in their past that they would have been subject to or any disease (no matter what) they may have had. I asked whether or not any member or their family had had the same symptoms -- long ago that would help with the genetics thing. That is the only thing I received. They listed all of their symptoms now, but not in the past -- or anything that they were exposed to. I thought if we could get this info together we could help our doctors since they know nothing about us. Hugs, Biddy Common denominator >> >> >>>Just interested in your thoughts.....If UC isn't always the common link to >>>PSC...what could be? What do those without UC have in common with the >>other >>>PSC patients? >>> >>>Food for thought >>> >>>Lynn >>> >>> >>>------------------------------------------------------------------------ >>>Get A 0% Intro APR Visa with Instant Approval right now a >>>GetSmart.com at http://clickhere./click/1270 >>> >>> >>> >>>eGroups.com home: /group/ >>> - Simplifying group communications >>> >>> >>> >>> >>> >> >> >>------------------------------------------------------------------------ >>Essential Feynman Library for $7.99! A $96.65 >>value of 3 books+6 audio tape set. Learn >>physics from Feynman renown for making >>complex ideas easy. Order NOW at Library >>of Science http://clickhere./click/1370 >> >> >>eGroups.com home: /group/ >> - Simplifying group communications >> >> >> >> > > >------------------------------------------------------------------------ >The Mental Health Practitioner’s Instant Resource >Library for $5.99! A 4-book set of time-saving >aids for clinical tasks - a $139.35 value >Join the book club NOW at >http://clickhere./click/1371 > > > >eGroups.com home: /group/ > - Simplifying group communications > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 Hi! The number one common denominator was chemicals -- from working in a chemical plant, to Agent Orange to common household chemicals. There were some who listed autonuclear antibodies -- believe it or not these are the only two that were mentioned. There has to be more. I asked that everyone really think about anything in their past that they would have been subject to or any disease (no matter what) they may have had. I asked whether or not any member or their family had had the same symptoms -- long ago that would help with the genetics thing. That is the only thing I received. They listed all of their symptoms now, but not in the past -- or anything that they were exposed to. I thought if we could get this info together we could help our doctors since they know nothing about us. Hugs, Biddy Common denominator >> >> >>>Just interested in your thoughts.....If UC isn't always the common link to >>>PSC...what could be? What do those without UC have in common with the >>other >>>PSC patients? >>> >>>Food for thought >>> >>>Lynn >>> >>> >>>------------------------------------------------------------------------ >>>Get A 0% Intro APR Visa with Instant Approval right now a >>>GetSmart.com at http://clickhere./click/1270 >>> >>> >>> >>>eGroups.com home: /group/ >>> - Simplifying group communications >>> >>> >>> >>> >>> >> >> >>------------------------------------------------------------------------ >>Essential Feynman Library for $7.99! A $96.65 >>value of 3 books+6 audio tape set. Learn >>physics from Feynman renown for making >>complex ideas easy. Order NOW at Library >>of Science http://clickhere./click/1370 >> >> >>eGroups.com home: /group/ >> - Simplifying group communications >> >> >> >> > > >------------------------------------------------------------------------ >The Mental Health Practitioner’s Instant Resource >Library for $5.99! A 4-book set of time-saving >aids for clinical tasks - a $139.35 value >Join the book club NOW at >http://clickhere./click/1371 > > > >eGroups.com home: /group/ > - Simplifying group communications > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 I have followed the discussion about a common denominator and I think it is an essential question. However, I do not think that there is a simple environmental answer. We should remember that some in our group are quite young and their exposure to chemicals, drugs, and other environmental factors is limited. The common denominator that we all share is most likely biochemical. Most researchers believe that PSC is an autoimmune disease in that our own bodies are attacking themselves. This is supported by the fact that many of us suffer from a myriad of other autoimmune problem ranging from UC, arthritis, asthma, and allergies. (I believe we even have someone with Lupus and some other rare autoimmune disorders.) The fundamental cause of all of these diseases is unknown. The result is that our immune system just overreacts. The cause is most likely genetic. PSC would need to involve at least a one rare defective recessive gene. For an individual to get the disease they would need to get defective alleles of this gene(s) from both their parents. (Thus the low incidence of 1 in 10,000) It is also possible that PSC may have different causes. (for example, there is a breast cancer gene that is responsible for some but not all breast cancer cases). I think the that most exciting cause of hope is the humane genome project. Geneticists will have mapped the location of all 100,000 genes in the human body in the next few years. All that we need to do is a genetic analysis of bunch of PSC patients and find out what makes us different. Finding the defective gene(s) and thus the defective protien(s) is a huge step towards finding a cure. This process will be too slow for some of us but probably not for the kids in our group. There is a book about PSC that is a collection of scientific articles presented at the International Falk Workshop in Oct. 1997. Amazingly enough it is called " Primary Sclerosing Cholangitis. " It can be ordered from Amazon.com for $107.00. It is short (about 130 pages) and has hideous orange cover. It is very technical but it also the only comprehensive resource out there. Adam dx96 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 I have followed the discussion about a common denominator and I think it is an essential question. However, I do not think that there is a simple environmental answer. We should remember that some in our group are quite young and their exposure to chemicals, drugs, and other environmental factors is limited. The common denominator that we all share is most likely biochemical. Most researchers believe that PSC is an autoimmune disease in that our own bodies are attacking themselves. This is supported by the fact that many of us suffer from a myriad of other autoimmune problem ranging from UC, arthritis, asthma, and allergies. (I believe we even have someone with Lupus and some other rare autoimmune disorders.) The fundamental cause of all of these diseases is unknown. The result is that our immune system just overreacts. The cause is most likely genetic. PSC would need to involve at least a one rare defective recessive gene. For an individual to get the disease they would need to get defective alleles of this gene(s) from both their parents. (Thus the low incidence of 1 in 10,000) It is also possible that PSC may have different causes. (for example, there is a breast cancer gene that is responsible for some but not all breast cancer cases). I think the that most exciting cause of hope is the humane genome project. Geneticists will have mapped the location of all 100,000 genes in the human body in the next few years. All that we need to do is a genetic analysis of bunch of PSC patients and find out what makes us different. Finding the defective gene(s) and thus the defective protien(s) is a huge step towards finding a cure. This process will be too slow for some of us but probably not for the kids in our group. There is a book about PSC that is a collection of scientific articles presented at the International Falk Workshop in Oct. 1997. Amazingly enough it is called " Primary Sclerosing Cholangitis. " It can be ordered from Amazon.com for $107.00. It is short (about 130 pages) and has hideous orange cover. It is very technical but it also the only comprehensive resource out there. Adam dx96 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 1999 Report Share Posted October 27, 1999 I have followed the discussion about a common denominator and I think it is an essential question. However, I do not think that there is a simple environmental answer. We should remember that some in our group are quite young and their exposure to chemicals, drugs, and other environmental factors is limited. The common denominator that we all share is most likely biochemical. Most researchers believe that PSC is an autoimmune disease in that our own bodies are attacking themselves. This is supported by the fact that many of us suffer from a myriad of other autoimmune problem ranging from UC, arthritis, asthma, and allergies. (I believe we even have someone with Lupus and some other rare autoimmune disorders.) The fundamental cause of all of these diseases is unknown. The result is that our immune system just overreacts. The cause is most likely genetic. PSC would need to involve at least a one rare defective recessive gene. For an individual to get the disease they would need to get defective alleles of this gene(s) from both their parents. (Thus the low incidence of 1 in 10,000) It is also possible that PSC may have different causes. (for example, there is a breast cancer gene that is responsible for some but not all breast cancer cases). I think the that most exciting cause of hope is the humane genome project. Geneticists will have mapped the location of all 100,000 genes in the human body in the next few years. All that we need to do is a genetic analysis of bunch of PSC patients and find out what makes us different. Finding the defective gene(s) and thus the defective protien(s) is a huge step towards finding a cure. This process will be too slow for some of us but probably not for the kids in our group. There is a book about PSC that is a collection of scientific articles presented at the International Falk Workshop in Oct. 1997. Amazingly enough it is called " Primary Sclerosing Cholangitis. " It can be ordered from Amazon.com for $107.00. It is short (about 130 pages) and has hideous orange cover. It is very technical but it also the only comprehensive resource out there. Adam dx96 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 30, 1999 Report Share Posted October 30, 1999 Hi Lynn, I don't know what everybody has in common, but your thought brings me back to a question that may or may not have been answered already. (I lost 2000 unread email messages when I restored my computer a few weeks ago.) tested positive for Auto Nuclear Anti-bodies (I believe the abbreviation is ANA, but I'm not positive.) I originally thought that ANA caused or started the PSC deterioration process. But I think I recall or someone stating that they didn't have them. Can somebody confirm for me then, - can PSC exist withOUT Auto Nuclear Antibodies? Common denominator > Just interested in your thoughts.....If UC isn't always the common link to > PSC...what could be? What do those without UC have in common with the other > PSC patients? > > Food for thought > > Lynn > > > ------------------------------------------------------------------------ > Get A 0% Intro APR Visa with Instant Approval right now a > GetSmart.com at http://clickhere./click/1270 > > > > eGroups.com home: /group/ > - Simplifying group communications > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 1999 Report Share Posted October 31, 1999 Biddy, Can you post to the list who has been exposed to what chemicals? I'd really like to have this info. Thanks a lot. Biddy Santon wrote: > Hi! > The number one common denominator was chemicals -- from working in a > chemical plant, to Agent Orange to common household chemicals. There were > some who listed autonuclear antibodies -- believe it or not these are the > only two that were mentioned. There has to be more. I asked that everyone > really think about anything in their past that they would have been subject > to or any disease (no matter what) they may have had. I asked whether or not > any member or their family had had the same symptoms -- long ago that would > help with the genetics thing. That is the only thing I received. > They listed all of their symptoms now, but not in the past -- or > anything that they were exposed to. > I thought if we could get this info together we could help our doctors > since they know nothing about us. > Hugs, > Biddy > Common denominator > >> > >> > >>>Just interested in your thoughts.....If UC isn't always the common link > to > >>>PSC...what could be? What do those without UC have in common with the > >>other > >>>PSC patients? > >>> > >>>Food for thought > >>> > >>>Lynn > >>> > >>> > >>>------------------------------------------------------------------------ > >>>Get A 0% Intro APR Visa with Instant Approval right now a > >>>GetSmart.com at http://clickhere./click/1270 > >>> > >>> > >>> > >>>eGroups.com home: /group/ > >>> - Simplifying group communications > >>> > >>> > >>> > >>> > >>> > >> > >> > >>------------------------------------------------------------------------ > >>Essential Feynman Library for $7.99! A $96.65 > >>value of 3 books+6 audio tape set. Learn > >>physics from Feynman renown for making > >>complex ideas easy. Order NOW at Library > >>of Science http://clickhere./click/1370 > >> > >> > >>eGroups.com home: /group/ > >> - Simplifying group communications > >> > >> > >> > >> > > > > > >------------------------------------------------------------------------ > >The Mental Health Practitioner’s Instant Resource > >Library for $5.99! A 4-book set of time-saving > >aids for clinical tasks - a $139.35 value > >Join the book club NOW at > >http://clickhere./click/1371 > > > > > > > >eGroups.com home: /group/ > > - Simplifying group communications > > > > > > > > > > > > ------------------------------------------------------------------------ > Java or juggling?. Everybody learns something at Learn2.com. Where > you'll find thousands of free 2torials, affordable online courses, and > useful tips for everyday life. http://clickhere./click/964 > > eGroups.com home: /group/ > - Simplifying group communications Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 1999 Report Share Posted October 31, 1999 Biddy, Can you post to the list who has been exposed to what chemicals? I'd really like to have this info. Thanks a lot. Biddy Santon wrote: > Hi! > The number one common denominator was chemicals -- from working in a > chemical plant, to Agent Orange to common household chemicals. There were > some who listed autonuclear antibodies -- believe it or not these are the > only two that were mentioned. There has to be more. I asked that everyone > really think about anything in their past that they would have been subject > to or any disease (no matter what) they may have had. I asked whether or not > any member or their family had had the same symptoms -- long ago that would > help with the genetics thing. That is the only thing I received. > They listed all of their symptoms now, but not in the past -- or > anything that they were exposed to. > I thought if we could get this info together we could help our doctors > since they know nothing about us. > Hugs, > Biddy > Common denominator > >> > >> > >>>Just interested in your thoughts.....If UC isn't always the common link > to > >>>PSC...what could be? What do those without UC have in common with the > >>other > >>>PSC patients? > >>> > >>>Food for thought > >>> > >>>Lynn > >>> > >>> > >>>------------------------------------------------------------------------ > >>>Get A 0% Intro APR Visa with Instant Approval right now a > >>>GetSmart.com at http://clickhere./click/1270 > >>> > >>> > >>> > >>>eGroups.com home: /group/ > >>> - Simplifying group communications > >>> > >>> > >>> > >>> > >>> > >> > >> > >>------------------------------------------------------------------------ > >>Essential Feynman Library for $7.99! A $96.65 > >>value of 3 books+6 audio tape set. Learn > >>physics from Feynman renown for making > >>complex ideas easy. Order NOW at Library > >>of Science http://clickhere./click/1370 > >> > >> > >>eGroups.com home: /group/ > >> - Simplifying group communications > >> > >> > >> > >> > > > > > >------------------------------------------------------------------------ > >The Mental Health Practitioner’s Instant Resource > >Library for $5.99! A 4-book set of time-saving > >aids for clinical tasks - a $139.35 value > >Join the book club NOW at > >http://clickhere./click/1371 > > > > > > > >eGroups.com home: /group/ > > - Simplifying group communications > > > > > > > > > > > > ------------------------------------------------------------------------ > Java or juggling?. Everybody learns something at Learn2.com. Where > you'll find thousands of free 2torials, affordable online courses, and > useful tips for everyday life. http://clickhere./click/964 > > eGroups.com home: /group/ > - Simplifying group communications Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 1999 Report Share Posted October 31, 1999 Biddy, Can you post to the list who has been exposed to what chemicals? I'd really like to have this info. Thanks a lot. Biddy Santon wrote: > Hi! > The number one common denominator was chemicals -- from working in a > chemical plant, to Agent Orange to common household chemicals. There were > some who listed autonuclear antibodies -- believe it or not these are the > only two that were mentioned. There has to be more. I asked that everyone > really think about anything in their past that they would have been subject > to or any disease (no matter what) they may have had. I asked whether or not > any member or their family had had the same symptoms -- long ago that would > help with the genetics thing. That is the only thing I received. > They listed all of their symptoms now, but not in the past -- or > anything that they were exposed to. > I thought if we could get this info together we could help our doctors > since they know nothing about us. > Hugs, > Biddy > Common denominator > >> > >> > >>>Just interested in your thoughts.....If UC isn't always the common link > to > >>>PSC...what could be? What do those without UC have in common with the > >>other > >>>PSC patients? > >>> > >>>Food for thought > >>> > >>>Lynn > >>> > >>> > >>>------------------------------------------------------------------------ > >>>Get A 0% Intro APR Visa with Instant Approval right now a > >>>GetSmart.com at http://clickhere./click/1270 > >>> > >>> > >>> > >>>eGroups.com home: /group/ > >>> - Simplifying group communications > >>> > >>> > >>> > >>> > >>> > >> > >> > >>------------------------------------------------------------------------ > >>Essential Feynman Library for $7.99! A $96.65 > >>value of 3 books+6 audio tape set. Learn > >>physics from Feynman renown for making > >>complex ideas easy. Order NOW at Library > >>of Science http://clickhere./click/1370 > >> > >> > >>eGroups.com home: /group/ > >> - Simplifying group communications > >> > >> > >> > >> > > > > > >------------------------------------------------------------------------ > >The Mental Health Practitioner’s Instant Resource > >Library for $5.99! A 4-book set of time-saving > >aids for clinical tasks - a $139.35 value > >Join the book club NOW at > >http://clickhere./click/1371 > > > > > > > >eGroups.com home: /group/ > > - Simplifying group communications > > > > > > > > > > > > ------------------------------------------------------------------------ > Java or juggling?. Everybody learns something at Learn2.com. Where > you'll find thousands of free 2torials, affordable online courses, and > useful tips for everyday life. http://clickhere./click/964 > > eGroups.com home: /group/ > - Simplifying group communications Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 1999 Report Share Posted October 31, 1999 , When I was first trying to figure out why I had elevated LFTs, I did a test for Auto Nuclear Antibodies. I recall my GI specialist saying that they were present in about 55% of patients with PSC. This was about 5 years ago so my memory isn't perfect, but I do recall the doctor saying that it is clue to a diagnosis but that it is not definitive. Adam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 1999 Report Share Posted October 31, 1999 , When I was first trying to figure out why I had elevated LFTs, I did a test for Auto Nuclear Antibodies. I recall my GI specialist saying that they were present in about 55% of patients with PSC. This was about 5 years ago so my memory isn't perfect, but I do recall the doctor saying that it is clue to a diagnosis but that it is not definitive. Adam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 , my husband worked for 15 years for Mobil Oil on the tugs and barges hauling gasoline and other types of fuel and was exposed to benzene as well as alot of other chemicals in fuels, I would assume. I remember when he was quite young, 20 or 21, coming home from work (they lived on the boat for a week or two at a time) and actually smelling gasoline on his breath (not a good thing!) I used to go crazy warning him that he should be wearing some kind of mask or breathing apparatus, especially when they went down into the tanks. He was young and foolish at the time, and feeling invincible, like so many 20 year olds do. I am not saying this is the cause of his PSC, but I will always wonder. Liz Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 I never added my chemical exposure list for Biddy. I worked at a Greenhouse in Eugene Oregon in 1975-76 and used many pesticides (if only I could remember the names). Insecticides and Fungicides, sometimes 300 gallons per week of the fungicides, but I always wore protective clothing and a respirator. Aftre returning to Denver I worked at another Greenhouse from 1977-1980 and used various chemicals but wore protective clothing and a respirator. I was exposed to Dieldrin (VERY toxic) at one point because the guy who sprayed it in that greenhouse didn't put up a sign saying not to go in there. I was also made to use DDT (illegal then) in one case. I also worked at a Geo-Chem Lab from 1980-82. I was exposed to many chemicals there, and analyzed samples for uranium. LOL! Hmmmmm. My first elevated enzymes were in March 1982. That's interesting isn't it? However, according to the hepatologists, my liver damage does not seem to be caused by chemicals or drugs. Dianne Arneill Dpa1228@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 Kenny works for a pest control company, so he works with pesticides (several of which have been banned, including DDT). I don't know if his contact with any chemicals caused his PSC, but one thing that seems to baffle the doc's a little is that there is no family history of autoimmune diseases. I know PSC is referred to as an autoimmune disease, but I'm not thoroughly convinced. It doesn't seem to fit. In the case of Autoimmune hepatitis, the body's immune system attacks the liver. It mistakes good things for bad and attacks. Is that what happens in PSC, only the ducts get attacked? It seems that PSC damage is caused more by bacterial infections in the ducts. If it is autoimmune, why doesn't prednisone work to slow it down?? It's used for other autoimmune diseases.... I know there's a link between Ulcerative Colitis and PSC, but why? Also, there's no set pattern. You don't acquire UC, then 10 years later show signs of PSC. People who are diagnosed with PSC, can develop UC before, after or during their PSC diagnosis (or maybe not at all). Do you think it's in the genes? Maybe they'll come up with a test to see who is predisposed to acquire these diseases, like they are doing with some cancers?? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 I have also wondered if my use of pesticides and other chemicals might have caused psc. However, if you look at the psc-list and ages, it's hard for me to believe that children have been exposed to harmful chemicals. I feel we should look deaper, perhaps polling our group with a comprehensive questionaire. mike in houston (diagnosed in 95) > > > <html><table><tr><td><pre> > Kenny works for a pest control company, so he works with pesticides (several > of which have been banned, including DDT). I don't know if his contact with > any chemicals caused his PSC, but one thing that seems to baffle the doc's a > little is that there is no family history of autoimmune diseases. > > I know PSC is referred to as an autoimmune disease, but I'm not thoroughly > convinced. It doesn't seem to fit. In the case of Autoimmune hepatitis, the > body's immune system attacks the liver. It mistakes good things for bad and > attacks. Is that what happens in PSC, only the ducts get attacked? It seems > that PSC damage is caused more by bacterial infections in the ducts. If it > is autoimmune, why doesn't prednisone work to slow it down?? It's used for > other autoimmune diseases.... > > I know there's a link between Ulcerative Colitis and PSC, but why? Also, > there's no set pattern. You don't acquire UC, then 10 years later show signs > of PSC. People who are diagnosed with PSC, can develop UC before, after or > during their PSC diagnosis (or maybe not at all). Do you think it's in the > genes? Maybe they'll come up with a test to see who is predisposed to > acquire these diseases, like they are doing with some cancers?? > > > > </pre></td></tr></table> > > <hr><center> > <a target= " egnewwin " href= " http://clickhere./click/886 " > > <center> > <img width= " 468 " height= " 60 " border= " 0 " > src= " http://clickhere./img/000886/sex_iQ_man.gif " > alt= " click here " > > </center> > <center> > Click Here! > </center> > </a> > </center> > > eGroups.com Home: <a href= " /group/ " >/group /</a><br> > <a href= " " >www.</a> - Simplifying group communications<br> > > > </html> > ________________________________________________________________ Get FREE voicemail, fax and email at http://voicemail.excite.com Talk online at http://voicechat.excite.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 What specifically is Auto Nuclear Antibodies? Lynn Re: Common denominator >, > >When I was first trying to figure out why I had elevated LFTs, I did a test >for Auto Nuclear Antibodies. I recall my GI specialist saying that they were >present in about 55% of patients with PSC. This was about 5 years ago so my >memory isn't perfect, but I do recall the doctor saying that it is clue to a >diagnosis but that it is not definitive. > >Adam > >------------------------------------------------------------------------ >The Mental Health Practitioner’s Instant Resource >Library for $5.99! A 4-book set of time-saving >aids for clinical tasks - a $139.35 value >Join the book club NOW at >http://clickhere./click/1371 > > >-- Easily schedule meetings and events using the group calendar! >-- /cal?listname= & m=1 > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 Adam, Okay, so what I don't get then is if Auto Nuclear Antibodies are attacking my son's liver, what is attacking the liver of the rest of you that don't have them? I thought the ANA's were the Garden of Eden character reps in our story. Maybe Prednisone helps cases WITH ANA's but not the cases WITHOUT. Or maybe the other way around. Or maybe I just don't have a clue. Re: Common denominator > , > > When I was first trying to figure out why I had elevated LFTs, I did a test > for Auto Nuclear Antibodies. I recall my GI specialist saying that they were > present in about 55% of patients with PSC. This was about 5 years ago so my > memory isn't perfect, but I do recall the doctor saying that it is clue to a > diagnosis but that it is not definitive. > > Adam > > ------------------------------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 1999 Report Share Posted November 1, 1999 Adam, Okay, so what I don't get then is if Auto Nuclear Antibodies are attacking my son's liver, what is attacking the liver of the rest of you that don't have them? I thought the ANA's were the Garden of Eden character reps in our story. Maybe Prednisone helps cases WITH ANA's but not the cases WITHOUT. Or maybe the other way around. Or maybe I just don't have a clue. Re: Common denominator > , > > When I was first trying to figure out why I had elevated LFTs, I did a test > for Auto Nuclear Antibodies. I recall my GI specialist saying that they were > present in about 55% of patients with PSC. This was about 5 years ago so my > memory isn't perfect, but I do recall the doctor saying that it is clue to a > diagnosis but that it is not definitive. > > Adam > > ------------------------------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
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