CFS & Impaired Peripheral Pulse Characteristics on Orthostasis -Potential Diagnostic Biomarker

[Guest guest]

http://1.usa.gov/y4Wc8Y

PubMed

US National Library of Medicine

National Institutes of Health

Physiol Meas. 2012 Jan 25;33(2):231-241. [Epub ahead of

print]

Chronic fatigue syndrome and impaired

peripheral pulse characteristics on

orthostasis-a new potential diagnostic

biomarker.

J, Murray A, Di C, Newton JL.

Microvascular Diagnostics, Regional Medical Physics

Department, Freeman Hospital, Newcastle upon Tyne NE7

7DN, UK.

Abstract

Autonomic nervous system dysfunction is frequently

reported in chronic fatigue syndrome (CFS) with orthostatic

intolerance, a common symptom that can be objectively

assessed.

The frequent finding of autonomic dysfunction and symptoms

on standing has the potential to provide a diagnostic

biomarker in chronic fatigue.

In this study we explored the clinical value of non-invasive

optical multi-site photoplethysmography (PPG) technology

to assess cardiovascular responses to standing.

Multi-site PPG pulses were collected from tissue pads of the

ears, fingers and toes of 14 patients with CFS and 14

age-matched sedentary subjects using a measurement

protocol of a 10 min baseline (subject supine) followed by 3

min of tilting on a tilt table (head-up to 70?).

Percentage change in pulse timing (pulse transit time, PTTf)

and pulse amplitude (AMP) at each site were calculated

using beat-to-beat pulse wave analysis.

A significant reduction in the overall pulse timing response to

controlled standing was found for the CFS group (using

summed absolute percentage change in PTTf for ear, finger

and toe sites, median change of 26% for CFS and 37% for

control with p = 0.002).

There were no significant differences between subject groups

for the AMP measure at any site.

Changes in AMP with tilt were, however, weakly significantly

and negatively correlated with fatigue severity (p < 0.05).

Receiver operating characteristic (ROC) analysis of timing

measures produced an area under the curve of 0.81.

Experimental linear discriminant classification analysis

comparing both timing and amplitude measures produced

an overall diagnostic accuracy of 82%.

Pulse wave abnormalities have been observed in CFS and

represent a potential objective measure to help differentiate

between CFS patients and healthy controls.

PMID: 22273713 [PubMed - as supplied by publisher]