Re: Articles on Oxytocin Spray

[Guest guest]

Where do you get it? Any pharmacy?

Joyce M. Dávila

Mamá de Verónica Marie

Puerto Rico

Articles on Oxytocin Spray

[Guest guest]

Coastal has it and Wellness also. Perhaps others but those are my

two favorites and I know they both have it... it is $25 for two

month supply of one squirt a day and $40-45 for two month supply of

two squirts a day. shipping on ice next day is $17-20. Please verify

these prices but this is what I think is correct. It is RX.

Hope this helps Joyce!

>

> Where do you get it? Any pharmacy?

>

> Joyce M. Dávila

> Mamá de Verónica Marie

> Puerto Rico

> Articles on Oxytocin Spray

>

>

>

>

>

[Guest guest]

So how does Oxytocin work? By enhancing seratonin levels?

Nandini

" Joyce M. Davila " wrote:

Where do you get it? Any pharmacy?

Joyce M. Dávila

Mamá de Verónica Marie

Puerto Rico

Articles on Oxytocin Spray

[Guest guest]

Is it injectable?

Joyce M. Dávila

Mamá de Verónica Marie

Puerto Rico

[Guest guest]

Joyce, it is pump nasal spray.. one or two squirts and it does not use

much with a squirt.. I have Slater sniff it up into his nose after I

squirt it. he was not too crazy about this initially but got used to

it. I practiced with saline nose spray even though the pump/bottle is

different than these. it does not burn or have any negatives that I can

see.

>

> Is it injectable?

>

> Joyce M. Dávila

> Mamá de Verónica Marie

> Puerto Rico

>

>

>

>

[Guest guest]

What improvements do you see with Oxytocin Spray?

Re: Articles on Oxytocin Spray

>

>Joyce, it is pump nasal spray.. one or two squirts and it does not use

>much with a squirt.. I have Slater sniff it up into his nose after I

>squirt it. he was not too crazy about this initially but got used to

>it. I practiced with saline nose spray even though the pump/bottle is

>different than these. it does not burn or have any negatives that I can

>see.

>

>>

>> Is it injectable?

>>

>> Joyce M. Dávila

>> Mamá de Verónica Marie

>> Puerto Rico

>>

>>

>>

>>

[Guest guest]

Nandini,

Oxytocin is a neural hormone so it has its own receptors. It is what is

responsible for telling your brain how to process social information. It

is also a hormone of labor: the same thing as pitocin. It is responsible

for helping your milk come in and in clamping down the uterus and in making

new mothers bond to their infants. Without oxytocin, the brain doesn't

register social signals...stuff like recognizing faces or in animals,

smells that tell you about the animal you just encountered. In animals

that have the gene knocked out for this protein, the behavior of the animal

is very autismish...he ignores other animals and doesn't participate in the

social exchanges that are typical. If they inject this mouse with

oxytocin, all of these abnormal behaviors go away and are replaced with

normal social behavior. They have even done studies of the brain showing

the hormone changes the place in the brain informaiton about social

exchanges is processed. Animals that form lifetime partnerships tend to

have oxytocin and those who love you then leave you do not tend to have a

lot of oxytocin.

The association of lack of oxytocin with repetitive behavior is a rather

new finding.

This is what I wrote on oxytocin years ago, but it goes into the connection

with sulfation problems that you find in autism.

After that I've put some relevant articles that may be of interest.

From 1997

Listmates,

I had a few thoughts on the pitocin issue related to my recent studies of

CCK. Thanks Kay, for posting the article you saw. I feel that the fact

that pitocin was needed to complete these pregnancies may speak of some

issues of biochemistry going on in mom that made her natural oxytocin

ineffective (pitocin is a manufactured oxytocin), and that those same

issues of biochemistry could have been an influence on development in utero

that may have nothing to do with direct effects of pitocin use.

I mentioned in an earlier post that it is possible that opiate excess and

sulfation problems could alter the body's use or manufacture of CCK. CCK

administered outside the brain can produce both the stimulation of

corticotrophin releasing hormone and oxytocin secretion from both the

pituitary and the hypothalamus. This is believed to happen through the

activation of the vagal nerve which has two brands of CCK receptors, the

type typically found in the brain, and the type typically found in the gut,

but the ones involved in oxytocin seem to be the type receptors more common

to the gut. They know that sulfated CCK8 will give rise to increases in

Fos protein in both the brain stem and in nerves known to encourage

oxytocin production in the hypothalamus. Involved in this process is the

appearance of a chemical called C-fos which is what they call an immediate

early gene. Interestingly, unsulfated CCK8 will engage the right CCK

receptors, but is incapable of stimulating this early gene expression that

is necessary to produce oxytocin. It might just get in the way and I

suppose could make pitocin less effective.

So, what does it mean? I think it may mean that if mother has poor

sulfation, she may have trouble in labor, because her body may be producing

adequate CCK to encourage the production of oxytocin, but it might not work

well if unsulfated CCK ends up engaging and blocking the receptors needed

to encourage the production of oxytocin. It just might be very inefficient

and might perhaps lead to stalled or slow labors.

Since CCK has some poorly understood functions in the brain that happen

primarily after the brain has already produced most of its neurons towards

the end of the second trimester, when the brain becomes more active in

making connections, then it may be that if mom has opiate excess problems

and sulfation problems, it may have some influence on how the brain

develops. Two events that are not directly related could occur together

because they have a common factor causing each event. The areas that show

the most response to peripheral CCK are the hypothalamus, the amygdala, and

the brainstem. We've heard of them before.

Now, just for comparison, here is a snapshot of my experience with pitocin,

and I DEFINITELY have had opiate excess problems, and have been happily off

wheat and milk for over twenty months. My second daughter is not autistic,

but did have developmental delays which have resolved since she quit eating

wheat and milk.

Both of my girls were delivered with pitocin. My first daughter had

already died in utero of unknown cause, but she was just at that magic age

when things in the brain's development switch over to new

priorities. After my cervix had ripened somewhat my doctor gave me a

prostaglandin cream that didn't work, and then he used pitocin. My blood

pressure dropped suddenly, but quickly recovered, and the rest of the

delivery was very straightforward.

When Grace was born, I had lots of slow or pre-labor all day, but I was

scheduled for induction the next morning, so at 2:00 a.m. we got to the

hospital. Sometime that morning when labor was quite active, the nurse

turned me on my side causing great pain, and my labor stopped cold. That

is when they used pitocin, and Grace came I'd guess six or seven hours

later (sorry, don't remember exactly the timing--I was too busy being angry

with that nurse!)

Another interesting angle is that I had great trouble getting my milk to

come in and required the help of a lactation consultant. Another function

of oxytocin is acting on the mammary glands to stimulate the production of

milk.

Hope this helps!

: Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R53-8.Click here

to read Links

Oxytocin receptor binding in the hypothalamus during gestation in rats.

* Bealer SL,

* Lipschitz DL,

* Ramoz G,

* Crowley WR.

Department of Pharmacology and Toxicology, College of Pharmacy,

University of Utah, Salt Lake City, Utah 84121, USA.

steve.bealer@...

Central oxytocin receptors (OTR) may be involved in adaptations of the

brain oxytocin (OT) system during gestation, which are critical for

systemic release of OT during parturition and lactation. We used

quantitative autoradiography to determine changes in OTR binding in

numerous brain sites during the course of gestation in the rat.

Furthermore, to evaluate the importance of ovarian steroids in mediating

pregnancy-related changes in OTR binding, we measured binding in

ovariectomized animals treated with progesterone and/or estrogen, and in

pregnant animals treated with exogenous progesterone during late gestation.

We found that OTR binding was significantly increased in the

paraventricular nucleus (PVN) and supraoptic nucleus (SON) by midgestation

(day 15) compared with control. In addition, there was a further

significant increase in OTR binding in these nuclei by late gestation (day

20). The bed nucleus of the stria terminalis (BNST) and the medial preoptic

area (MPOA) also showed significant gestation-associated increases in OTR

binding, which were similar during mid- and late pregnancy. Treatment with

exogenous progesterone throughout pregnancy did not alter the increase in

OTR binding characteristic of late gestation in any of these brain sites.

Finally, estrogen treatment in ovariectomized animals resulted in increased

OTR binding in the SON, BNST, and MPOA, but not the PVN. These data

demonstrate that OTR binding in the hypothalamus is increased during mid-

and late-gestation, compared with ovariectomized control animals, which may

be mediated by increased estradiol.

PMID: 16832906 [PubMed - indexed for MEDLINE]

Neuropsychopharmacology. 2003 Jan;28(1):193-8.Click here to read Links

Oxytocin infusion reduces repetitive behaviors in adults with autistic

and Asperger's disorders.

* Hollander E,

* Novotny S,

* Hanratty M,

* Yaffe R,

* DeCaria CM,

* Aronowitz BR,

* Mosovich S.

Department of Psychiatry, Seaver Autism Research Center, Mount Sinai

School of Medicine, New York, NY 10029, USA. eric.hollander@...

Autism is a neurodevelopmental disorder characterized by dysfunction

in three core behavioral domains: repetitive behaviors, social deficits,

and language abnormalities. There is evidence that abnormalities exist in

peptide systems, particularly the oxytocin system, in autism spectrum

patients. Furthermore, oxytocin and the closely related peptide vasopressin

are known to play a role in social and repetitive behaviors. This study

examined the impact of oxytocin on repetitive behaviors in 15 adults with

autism or Asperger's disorder via randomized double-blind oxytocin and

placebo challenges. The primary outcome measure was an instrument rating

six repetitive behaviors: need to know, repeating, ordering, need to

tell/ask, self-injury, and touching. Patients with autism spectrum

disorders showed a significant reduction in repetitive behaviors following

oxytocin infusion in comparison to placebo infusion. Repetitive behavior in

autism spectrum disorders may be related to abnormalities in the oxytocin

system, and may be partially ameliorated by synthetic oxytocin infusion.

PMID: 12496956 [PubMed - indexed for MEDLINE]

: Biol Psychiatry. 2006 Aug 10; [Epub ahead of print]Click here to read Links

Oxytocin Increases Retention of Social Cognition in Autism.

* Hollander E,

* Bartz J,

* Chaplin W,

* A,

* Sumner J,

* Soorya L,

* Anagnostou E,

* Wasserman S.

Mount Sinai School of Medicine.

BACKGROUND: Oxytocin dysfunction might contribute to the development

of social deficits in autism, a core symptom domain and potential target

for intervention. This study explored the effect of intravenous oxytocin

administration on the retention of social information in autism. METHODS:

Oxytocin and placebo challenges were administered to 15 adult subjects

diagnosed with autism or Asperger's disorder, and comprehension of

affective speech (happy, indifferent, angry, and sad) in neutral content

sentences was tested. RESULTS: All subjects showed improvements in

affective speech comprehension from pre- to post-infusion; however, whereas

those who received placebo first tended to revert to baseline after a

delay, those who received oxytocin first retained the ability to accurately

assign emotional significance to speech intonation on the speech

comprehension task. CONCLUSIONS: These results are consistent with studies

linking oxytocin to social recognition in rodents as well as studies

linking oxytocin to prosocial behavior in humans and suggest that oxytocin

might facilitate social information processing in those with autism. These

findings also provide preliminary support for the use of oxytocin in the

treatment of autism.

PMID: 16904652 [PubMed - as supplied by publisher]

: Biol Res. 2006;39(2):251-8. Epub 2006 Jul 25. Links

Social stimuli cause changes of plasma oxytocin and behavior in guinea

pigs.

* Wallner B,

* Dittami J,

* Machatschke I.

Department of Anthropology, University of Vienna, Vienna, Austria.

bernard.wallner@...

The neuropeptide oxytocin (OXT) is a key factor in the initiation and

regulation of sociosexual behavior. The present study analyzes the effects

of cohabitation and social challenge on plasma OXT concentration rates in

guinea pig pairs in relation to male sociosexual behavior. The cohabitation

phase lasted 3 days. On day 4, the pair was socially challenged by

introducing an unfamiliar male. Displayed male sexual behavior varied

significantly during cohabitation, with peaks on day 1. Sociopositive

behavior, i.e., side-by-side contact, was increased on days 3 and 4.

Cohabitation per se led to elevated plasma OXT concentrations only in

males. In contrast, both sexes reacted with increased plasma OXT

concentrations to the social challenge (day 4). At that time, male OXT was

significantly correlated with sexual behavior and female OXT with

sociosexual behavior received from the partner. Additionally, pairs were

synchronized in their OXT release during days 3 and 4. We conclude that

cohabitation causes sexually dimorphic plasma OXT concentration patterns in

guinea pigs. Secondly, the conformity of OXT release in both sexes may

represent an endocrine marker for long-term cohabitation, which is

reflected behaviorally by increased spatial proximity.

PMID: 16874400 [PubMed - in process]

At 05:41 PM 9/19/2006 -0700, you wrote:

>So how does Oxytocin work? By enhancing seratonin levels?

>

>Nandini

>

> " Joyce M. Davila "

><<mailto:joycemdavila%40gmail.com>joycemdavila@...> wrote:

>Where do you get it? Any pharmacy?

>

>Joyce M. Dávila

>Mamá de Verónica Marie

>Puerto Rico

> Articles on Oxytocin Spray

>

>

[Guest guest]

Has helped with calming... elimination of hyper behaviors. Also more

social and initiating interactions more. Beginning to seek affection

and give it freely which was lost with ASD regression.

> >>

> >> Is it injectable?

> >>

> >> Joyce M. Dávila

> >> Mamá de Verónica Marie

> >> Puerto Rico

> >>

> >>

> >>

> >>