Osteocyte viability with glucocorticoid treatment: relation to histomorphometry

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Ann Rheum Dis. 2003 Dec;62(12):1215-7.

Osteocyte viability with glucocorticoid treatment: relation to

histomorphometry.

Sambrook PN, DR, AE, BG, Mason RS.

Institute of Bone and Joint Research, Royal North Shore Hospital,

University of Sydney, Australia. sambrook@...

BACKGROUND: Glucocorticoid induced osteoporosis is a common clinical

problem. OBJECTIVE: To determine the pathophysiology of glucocorticoid

induced osteoarthritis at the organ level. METHODS: Iliac crest biopsy

specimens were obtained from nine patients receiving prednisone

treatment for rheumatoid arthritis. Osteocyte viability and

histomorphometric indices were assessed. RESULTS: Compared with

controls, glucocorticoid treated subjects had reduced trabecular

thickness and increased erosion. The number of viable osteocytes was

significantly decreased in glucocorticoid treated patients compared with

controls.

CONCLUSION: The impaired bone formation, increased erosion

and, importantly, loss of viable osteocytes are all likely to contribute

to the increased risk of fracture in these patients.

Publication Types:

a.. Clinical Trial

b.. Controlled Clinical Trial

PMID: 14644862

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