Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series

[Guest guest]

J Rheumatol. 2003 Oct;30(10):2287-91.

Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case

series.

Jarrett SJ, Cunnane G, Conaghan PG, Bingham SJ, Buch MH, Quinn MA, Emery

P.

Academic Unit of Musculoskeletal Medicine, University of Leeds, Great

Street, Leeds LS1 3EX, United Kingdom.

As experience with anti-tumor necrosis factor (TNF-alpha) therapy

increases, there has been the expected emergence of reports on uncommon

side effects. Large clinical trials identified the development of

autoantibodies and postmarketing surveillance has identified problems

including tuberculosis. There have been several case reports of

drug-induced systemic lupus erythematosus. We describe eight patients

with rheumatoid arthritis treated with anti-TNF therapies who developed

presumed vasculitis, with different pathophysiologic causes. We discuss

the literature and potential causal mechanisms, including disease

activity, the role of autoantibodies, and shifts in T cell responses.

Publication Types:

a.. Case Reports

PMID: 14528531

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org