Maternal age and family history are risk factors for AS

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J Rheumatol. 2003 Oct;30(10):2182-5.

Maternal age and family history are risk factors for ankylosing

spondylitis.

Jimenez-Balderas FJ, Zonana-Nacach A, ML, Talavera JO,

Barile-Fabris L, - ME, Arellano J, Fraga A.

Rheumatology Department and the Clinical Epidemiology Research Unit,

Hospital de Especialidades, Centro Medico Nacional La Raza, Seris y

Zaachila S/N, Colonia La Raza, CP 02990, Mexico City, Mexico.

fjjimenez19@...

OBJECTIVE: To investigate prevalence and gender distribution in parents

of children with ankylosing spondylitis (AS). METHODS: Family history of

AS (parents, uncles, and aunts), maternal age at delivery, and

consecutive pregnancy number were assessed in the relatives of 40

Mexican Mestizo patients with definite AS (New York Criteria). RESULTS:

We evaluated the family history of AS in 34 families of 40 AS patients;

12 with none, 4 with a paternal history (4 healthy fathers with a

brother with AS) (odds ratio, OR, 1.37, p = 0.75), 15 with a maternal

history of AS, (15 healthy mothers with a brother with AS) (OR 1.4, p =

0.55), and 3 with both lines (OR 0.84, p = 0.92). In these families AS

was more frequent in males (29%) than in females (10%), OR 3.40 (95%

confidence interval, CI: 1.43-8.29, p = 0.003). Juvenile onset was more

common in the offspring of mothers with family history (72%) (OR 13.0,

95% CI: 1.68-147.48, p = 0.009). The number of first-born children with

AS (18%) was similar to the later-born children (23%) (OR 1.37, 95% CI:

0.38-5.31, p = 0.78). The frequency of AS increased when the maternal

age at delivery was < or = 30 years (OR 0.20, 95% CI: 0.04-0.75, p =

0.01).

CONCLUSION: In Mexican Mestizo patients, there is no correlation between

the risk for AS and the gender of the affected parent. However we found

an association between juvenile onset and maternal family history with

an increased incidence in patients with younger mothers.

PMID: 14528515

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