ME/CFS -Xenotropic & polytropic murine leukemia virus-related sequences not detected in majority of patients

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PubMed

New Microbiol. 2012 Jul;35(3):341-4.

Epub 2012 Jun 30.

Xenotropic and polytropic

murine leukemia virus-related

sequences are not detected in

the majority of patients with

chronic fatigue syndrome.

Paolucci S, Piralla A, Zanello

C, Minoli L, Baldanti F.

S.S. Virologia Molecolare, S.C. Virologia e

Microbiologia, Fondazione IRCCS

Policlinico San Matteo, Pavia, Italy.

Abstract

XMRV and polytropic MLV-related virus

have been controversially associated

with chronic fatigue syndrome (CFS).

Subsequent reports failed to detect

XMRV and MLV-related virus in CFS

patients, and the previous results have

been interpreted as a massive

laboratory contamination by mouse

DNA sequences.

Among 12 sequential CFS patients, two

were positive for XMRV/MLV sequences.

In contrast, 40 selected control subjects

were negative.

CSF patients and controls were negative

for mitochondrial mouse-specific DNA

sequences.

These findings do not confirm the high

frequency of MLV-related viruses

infection in CFS patients, but also

contrast the widespread laboratory

contamination previously suggested.

PMID: 22842604 [PubMed - in process]