Prevalence of antibodies against alpha-fodrin in Sjogren's syndrome

February 9, 2004

Rheumatol. 2003 Oct;30(10):2157-9.

Prevalence of antibodies against alpha-fodrin in Sjogren's syndrome:

comparison of 2 sets of classification criteria.

Witte T, Matthias T, Oppermann M, Helmke K, HH, Schmidt RE,

Tishler M.

Abteilung Klinische Immunologie, Medizinische Hochschule,

Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

witte.torsten@...

OBJECTIVE: To compare the prevalence of antibodies against alpha-fodrin

in Sjogren's syndrome (SS) classified according to San Diego and

European Community Study Group (ESG) criteria. METHODS: The prevalence

and mean concentrations of IgA and IgG autoantibodies against

alpha-fodrin were determined and compared in patients with SS classified

either according to San Diego criteria or to criteria of the ESG by

ELISA. RESULTS: IgA antibodies against alpha-fodrin were detected in 88%

and IgG antibodies against alpha-fodrin in 64% and either of these

antibodies in 93% of 85 patients classified according to San Diego

criteria. Antibodies against Ro were present in 38% of these sera. IgA

antibodies against alpha-fodrin were detected in 61%, IgG antibodies

against alpha-fodrin in 51%, and any of these antibodies in 73% of 51

patients classified according to the ESG criteria. The mean

concentrations of both IgA and IgG antibodies against alpha-fodrin that

seem to correlate with disease activity were higher in patients

classified according to the San Diego criteria.

CONCLUSION: Antibodies against alpha-fodrin are detectable in almost all

sera obtained from patients with SS classified according to the San

Diego criteria and are significantly more prevalent than antibodies

against Ro. The lower prevalence of the autoantibodies in patients

classified according to the ESG criteria reflects the lower specificity

of these criteria for SS.

PMID: 14528510

I'll tell you where to go!

Mayo Clinic in Rochester

s Hopkins Medicine

Recommended Posts