Long-term 1,25(OH)2 vitamin D therapy increases bone mineral density in osteopenic women. Comparison with the effect of plain vitamin D

January 16, 2008

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Long-term 1,25(OH)2 vitamin D therapy increases bone mineral density in

osteopenic women. Comparison with the effect of plain vitamin D.

Zofkova I, Hill M.

Institute of Endocrinology, Prague, Czech Republic. izofko@....

BACKGROUND AND AIMS: Although the bone protective effect of vitamin D

has been studied intensively, the usefulness of 1,25(OH)2D3 in treating

osteoporosis is still questionable. The aim of the present prospective

study was to evaluate the effect of a standard pharmacological dose of

1,25(OH)2D3 in postmenopausal unsubstituted women. METHODS: Our study

group comprised 52 post-menopausal women with low normal or osteopenic

values of bone mineral density (BMD). Thirty-two of them were treated

with 1,25(OH)2D3 for 3 years. In parallel, another group of women was

treated with cholecalciferol (n=20). Vitamin D adequacy before

administration of 1,25(OH)2D3 and compliance with treatment were checked

by serum PTH levels, which were assessed at the start and three times in

the course of treatment. RESULTS: Increase in BMD at the spine at the

end of the 1st, 2nd and 3rd years of treatment with 1,25(OH)2D3

(expressed as a percentage of the value before treatment) was higher,

but did not significantly differ from the effect of plain vitamin D. A

significant increase in BMD at the hip at the end of the 3rd (but not

the 1st and 2nd) year of treatment with 1,25(OH)2D3 was found (p<0.05,

compared with the effect of plain vitamin D). The protective effect of

cholecalciferol was found only on spine but not hip BMD. CONCLUSION: The

study supports the hypothesis that long-term administration of

1,25(OH)2D3 is effective in treating low bone mass in postmenopausal women.

PMID: 18172369 [PubMed - in process]

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