Re: Complete recovery from refractory ITP in three patients treated with Enbrel (etanercept)

[Guest guest]

-Thank you so much for these articles. i find them very

enlightening! I have copied them and am going to show them to both

my hemo and ra dr.

Thanks for all your time in this , it is greatly appreciated!

1-- In , " "

<Matsumura_Clan@m...> wrote:

> Am J Hematol. 2003 Jun;73(2):135-40.

>

> Comment in:

> Curr Rheumatol Rep. 2003 Oct;5(5):381.

>

> Complete recovery from refractory immune thrombocytopenic purpura

in

> three patients treated with etanercept.

>

> McMinn JR Jr, Cohen S, J, Lilly S, Parkhurst J, Tarantino MD,

> Terrell DR, JN.

>

> Hematology-Oncology Section, Department of Medicine, University of

> Oklahoma Health Sciences Center, Oklahoma City 73190, USA.

>

> Management of patients with immune thrombocytopenic purpura (ITP)

who

> have persistent, severe, and symptomatic thrombocytopenia following

> splenectomy is difficult and empirical. No single agent or regimen

> provides long-term success for most patients, and for most

treatments it

> is difficult to assess whether benefits outweigh risks. We report

three

> consecutive patients with critical chronic refractory ITP, who

responded

> promptly and completely following treatment with etanercept, an

> inhibitor of tumor necrosis factor-alpha. These patients had

failed 6-11

> previous treatments. In the first patient, etanercept was given

for its

> approved indication: a flare of co-existing rheumatoid arthritis.

The

> next two patients were treated with etanercept because of

successful

> outcomes in the previous patients. Although etanercept appeared to

be

> effective treatment for ITP in these 3 patients, the experimental

nature

> of this treatment and the potential risks must be emphasized. On

the

> basis of these case reports, a clinical trial has been initiated to

> systematically evaluate the efficacy and risks of etanercept in the

> management of children and adults with chronic ITP. Copyright 2003

> Wiley-Liss, Inc.

>

> PMID: 12749017

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org