Beneficial Effects of Omega-3 Fatty Acids in Patients with Nonalcoholic Fatty Liver Disease

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Beneficial Effects of Omega-3 Fatty Acids in Patients with Nonalcoholic

Fatty Liver Disease

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Effects of omega-3 polyunsaturated fatty acids in subjects

with nonalcoholic fatty liver disease, " Spadaro L, Magliocco O, et al,

Dig Liver Dis, 2007 Dec 2; [Epub ahead of print]. (Address: Dept of

Internal Medicine, Ospedale Garibaldi-Nesima, University of Catania, Italy).

Summary: In a study involving 40 patients with nonalcoholic fatty liver

disease, results indicate that supplementation with omega-3

polyunsaturated fatty acids (omega-3 PUFAs) may exert beneficial

effects. The patients were randomized to an AHA recommended diet

supplemented with omega-3 PUFAs (2g/d) (n=20) or an AHA diet alone

(n=20), for a period of 6 months. At intervention end, patients in the

omega-3 PUFAs-supplemented group showed a decrease in alanine

aminotransferase, triglycerides, serum tumor necrosis factor-alpha

levels and HOMA(IR). Additionally, complete fatty liver regression was

observed in 33.4% of patients in the omega-3 PUFAs-supplemented group,

and an overall reduction in 50% of the patients. Thus, the authors of

this study conclude, " Our results indicate that alanine

aminotransferase, triglyceride and serum tumor necrosis factor-alpha

levels, as well as fatty liver improved after polyunsaturated fatty acid

administration. "

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