Vitamin B6 May Reduce the Symptoms of Tardive Dyskinesia

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Vitamin B6 May Reduce the Symptoms of Tardive Dyskinesia

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Vitamin B6 treatment for tardive dyskinesia: a randomized,

double-blind, placebo-controlled, crossover study, " Lerner V, Miodownik

C, et al, J Clin Psychiatry, 2007; 68(11): 1648-54. (Address: Division

of Psychiatry, Ministry of Health Be'er Sheva Mental Health Center,

Faculty of Health Sciences, Ben-Gurion University of the Negev,

Be'er-Sheva, Israel. E-mail: lernervld@... ).

Summary: In a 26-week, double-blind, placebo-controlled study involving

50 inpatients diagnosed with schizophrenia or schizoaffective disorder

and tardive dyskinesia (TD), supplementation with vitamin B6 (1200 mg/d)

for a period of 12 weeks was found to reduce symptoms of tardive

dyskinesia. In a crossover fashion, subjects were assigned to either

receive 1200 mg of vitamin B6 per day, or a placebo, for a period of 12

weeks. This was followed by a 2-week washout period, after which the

groups were crossed over to receive the other treatment for another 12

week period. Results showed that after treatment with vitamin B6,

subjects were found to have significantly less symptoms (assessed via

scores on the extra-pyramidal symptom rating scale, the Parkinsonism

subscale, and the dyskinesia subscale), than after treatment with

placebo. After treatment with vitamin B6, global impression score

reduced 2.4 points from baseline, as compared to a mere 0.2 point

decrease in symptom score afte r treatment with placebo. Parkinsonism

reduced by 18.5 points after treatment with vitamin B6, compared to 1.4

points after placebo, and dyskinesia scores reduced by 5.2 points after

treatment with vitamin B6, while increasing by -0.8 points after

placebo. These results suggest that treatment with 1200 mg/day vitamin

B6 may be a safe and effective treatment for reducing symptoms of

tardive dyskinesia. Additional research is warranted. Vitasearch

Comment: Doses of Vitamin B6 exceeding 200mg/day on a chronic basis

should be undertaken under strict medical supervision.

--

ne Holden, MS, RD < fivestar@... >

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

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