Re: The Underlying Cause of Suicides and Homicides with SSRIs: Is It the Drugs, the Doctors, or the Drug Companies?

[Guest guest]

: I understand the importance of these articles but I also have

a disagreement with a statement in it....

Even psychiatrists are often appallingly ignorant about how SSRIs

work. This was made clear in a January 5, 2004, article in The New

York Times titled " A Doctor's Toxic Shock. " 14 A doctor taking

Wellbutrin herself described her reaction: " I developed insomnia,

agitation and tremors... panic attacks started... I needed every

ounce of energy to concentrate at work.... Sometimes

In a manner of speaking wellbutrin is not classified as an SSRI....

http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%

20Monographs/CPS-%20%28General%20Monographs-%20W%29/WELLBUTRIN.html

Action And Clinical Pharmacology: Bupropion is an antidepressant of

the aminoketone class. It is chemically unrelated to tricyclic,

tetracyclic, selective serotonin re-uptake inhibitors or other known

antidepressant agents. Its structure closely resembles that of

diethylpropion. It is related to the phenylethylamines.

The mechanism of bupropion's antidepressant activity is unknown but

appears to be mediated by noradrenergic (and possibly dopaminergic),

rather than serotonergic mechanisms. Preclinical studies have shown

that bupropion blocks noradrenalin (NA) reuptake and dopamine (DA)

reuptake. Its major metabolite (hydroxybupropion), which in man is

present at blood levels 10 to 20-fold higher than buproprion, blocks

only NA reuptake.

I also feel some resposibility has to be the patients, you must keep

your docs informed of what is going on and I think there are so many

under the skin type feelings about depression there is not always

full discloser on both sides....Kathi in OK

> MedicationSense.com

> Pre-Release from the MedicationSense E-Newsletter April - June,

2004

> by Dr. Jay S. Cohen

>

> " The Underlying Cause of Suicides and Homicides with SSRI

> Antidepressants: Is It the Drugs, the Doctors, or the Drug

Companies?

> How a dysfunctional medical-pharmaceutical complex causes and

> perpetuates unnecessary harm " :

>

>

http://www.medicationsense.com/articles/april_june_04/underlying_caus

e.html

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

[Guest guest]

Kathi,

True, Wellbutrin/Zyban (bupropion) is not classified as an SSRI, but it

is similar to SSRIs and has many SSRI-like side effects. It has been

implicated in serotonin syndrome. It's mechanism of action is unknown.

Two paragraphs down in the same article, Cohen points out that

Wellbutrin is not an SSRI:

" There is no excuse for not recognizing SSRI reactions. There is

extensive literature on the dangers with SSRIs 9-13, 15-26, and anxiety

and agitation are listed as side effects in the package inserts of most

SSRI drugs and Wellbutrin (which although not an SSRI, can cause

anxiety.) So it is alarming that so many intelligent, capable doctors

are so confused when typical SSRI side effects develop. Yet, if these

doctors are relying on the information provided by drug companies and

their 90,000 sales reps and drug company-underwritten, expenses-paid

seminars and conferences, maybe it isn't so surprising after all. "

I wholeheartedly agree - full disclosure and researching what drugs

you're on is a must. You know your body best, and your physician cannot

read your mind. And if your doctor is not taking your concerns,

especially related to possible adverse reactions to your meds,

seriously, you must find another.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: The Underlying Cause of Suicides and Homicides

with SSRIs: Is It the Drugs, the Doctors, or the Drug Companies?

> : I understand the importance of these articles but I also have

> a disagreement with a statement in it....

>

>

> Even psychiatrists are often appallingly ignorant about how SSRIs

> work. This was made clear in a January 5, 2004, article in The New

> York Times titled " A Doctor's Toxic Shock. " 14 A doctor taking

> Wellbutrin herself described her reaction: " I developed insomnia,

> agitation and tremors... panic attacks started... I needed every

> ounce of energy to concentrate at work.... Sometimes

>

> In a manner of speaking wellbutrin is not classified as an SSRI....

>

> http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%

> 20Monographs/CPS-%20%28General%20Monographs-%20W%29/WELLBUTRIN.html

>

>

> Action And Clinical Pharmacology: Bupropion is an antidepressant of

> the aminoketone class. It is chemically unrelated to tricyclic,

> tetracyclic, selective serotonin re-uptake inhibitors or other known

> antidepressant agents. Its structure closely resembles that of

> diethylpropion. It is related to the phenylethylamines.

>

> The mechanism of bupropion's antidepressant activity is unknown but

> appears to be mediated by noradrenergic (and possibly dopaminergic),

> rather than serotonergic mechanisms. Preclinical studies have shown

> that bupropion blocks noradrenalin (NA) reuptake and dopamine (DA)

> reuptake. Its major metabolite (hydroxybupropion), which in man is

> present at blood levels 10 to 20-fold higher than buproprion, blocks

> only NA reuptake.

>

> I also feel some resposibility has to be the patients, you must keep

> your docs informed of what is going on and I think there are so many

> under the skin type feelings about depression there is not always

> full discloser on both sides....Kathi in OK