Dietary Fiber Intake May Help Reduce the Risk of Endometrial Cancer

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Dietary Fiber Intake May Help Reduce the Risk of Endometrial Cancer

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Association between dietary fiber and endometrial cancer: a

dose-response meta-analysis, " Bandera EV, Kushi LH, et al, American

Journal of Clinical Nutrition, 2007; 86(6): 1730-1737. (Address: The

Cancer Institute of New Jersey, Wood Medical School, New

Brunswick, NJ 08903, USA. E-mail: elisa.bandera@...).

Summary: In a dose-response meta-analysis of studies examining the

relationship between dietary fiber consumption and endometrial cancer

risk, an inverse association was found between dietary fiber intake and

endometrial cancer. The authors conducted a systematic literature review

of articles published through February 2007 and identified 10 studies

for analysis (1 case-cohort study and 9 case-control studies). The

random-effects summary risk estimate was found to be 0.82 per 5 g/1000

kcal dietary fiber (based on 7 case-control studies), with no evidence

of heterogeneity. Comparing the highest versus the lowest intakes of

dietary fiber, the random-effects summary estimate was 0.71, with no

evidence of heterogeneity either (ased on 8 case-control studies). In

the one prospective study which evaluated the association between

dietary fiber intake and endometrial cancer, results did not show a

beneficial effect of fiber consumption. The authors conclude, " Although

the current evidenc e, based on data from case-control studies, supports

an inverse association between dietary fiber and endometrial cancer,

additional population-based studies, particularly cohort studies, are

needed before definitive conclusions can be drawn. "

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