Re: ENG>ENG: adjuvant setting

[Guest guest]

Good morning,

The following may help:

http://www.thefreedictionary.com/adjuvant

Best regards,

Augustine LINGUIST

> **

>

>

> A small increase in toxicity was observed in patients who received zzz,

> but all of these patients had received prior www in the adjuvant setting -

> I can't see what 'adjuvant setting' means here. Any ideas?

>

> Thanks,

>

>

>

>

>

[Guest guest]

Le 15/04/2012 11:24, a écrit :

> A small increase in toxicity was observed in patients who received zzz,

> but all of these patients had received prior www in the adjuvant setting -

> I can't see what 'adjuvant setting' means here. Any ideas?

In cancer terms an adjuvant treatment is given after the main treatment

to cure the disease based on the statistical possibility that some

undetected cancer focus may remain with the intention of destroying it

(put cancer and adjuvant into Google)

but in your case the adjuvant was given before the treatment with zzz,

strictly, this again referring to cancer, would be neo-adjuvant

treatment if it was given to improve the chances of success with zzz (by

for example reducing tumour size) but perhaps could possibly simply be

referred to as adjuvant treatment.

As an example of this use of adjuvant prior to a main action, many years

ago when producing an animal model of RA I used Freund's adjuvant to

potentiate antibody reactions before challenging with an antigen. The

context isn't clinical but the adjuvant was given before the event.

HTH

[Guest guest]

Thanks, .

This text is very poorly written (in fact, I am sure it's a translation by

a non-native). Elsewhere, it does talk about 'neo-adjuvant'. So, the

terminology is inconsistent.

BTW, why is NEO-adjuvant, and not e.g. PRE-?

> Le 15/04/2012 11:24, a écrit :

>> A small increase in toxicity was observed in patients who received zzz,

>> but all of these patients had received prior www in the adjuvant setting

>> -

>> I can't see what 'adjuvant setting' means here. Any ideas?

> In cancer terms an adjuvant treatment is given after the main treatment

> to cure the disease based on the statistical possibility that some

> undetected cancer focus may remain with the intention of destroying it

> (put cancer and adjuvant into Google)

> but in your case the adjuvant was given before the treatment with zzz,

> strictly, this again referring to cancer, would be neo-adjuvant

> treatment if it was given to improve the chances of success with zzz (by

> for example reducing tumour size) but perhaps could possibly simply be

> referred to as adjuvant treatment.

> As an example of this use of adjuvant prior to a main action, many years

> ago when producing an animal model of RA I used Freund's adjuvant to

> potentiate antibody reactions before challenging with an antigen. The

> context isn't clinical but the adjuvant was given before the event.

>

> HTH

>

>

>

[Guest guest]

Le 15/04/2012 18:45, kinory@... a écrit :

> Thanks, .

>

> This text is very poorly written (in fact, I am sure it's a translation by

> a non-native). Elsewhere, it does talk about 'neo-adjuvant'. So, the

> terminology is inconsistent.

>

> BTW, why is NEO-adjuvant, and not e.g. PRE-?

Sorry can't answer that! It is certainly a pre-treatment but perhaps

pre-treatment would include treatment of any sort given before the event

whatever its purpose whereas a neoadjuvant always has the purpose of

facilitating the main treatment.

H

[Guest guest]

Many thanks.

It's the word 'setting' that was holding me up, not 'adjuvant'. I have

decided to construe it as 'adjuvant treatment'.

> Good morning,

>

> The following may help:

>

> http://www.thefreedictionary.com/adjuvant

>

> Best regards,

>

> Augustine LINGUIST

>

>

>

>

>> **

>>

>>

>> A small increase in toxicity was observed in patients who received zzz,

>> but all of these patients had received prior www in the adjuvant setting

>> -

>> I can't see what 'adjuvant setting' means here. Any ideas?

>>

>> Thanks,

>>

>>

>>

>>

>>

>

>

>