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Re: MTX and leukovorin

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Joanne,

I have heard of this. MTX is a folic acid antagonist, meaning that it is a

chemical that inhibits a

cell¹s capacity to use folic acid. Since taking folic acid can interfere

with the effectiveness of mtx,

many doctors don¹t prescribe folic acid on the day the mtx is taken.

When my liver enzymes were elevated from mtx I took folic acid but I also

took milk thistle.

Milk Thistle , an herb, has a long history of being a liver protector. SAMe

also has been demonstrated

to protect the liver from drug-induced damage.

Milk Thistle's Liver-Protective Properties

http://www.chiro.org/nutrition/FULL/Milk_Thistle_Liver_Protective_Properties

..html

Milk Thistle

http://www.healthcentral.com/PeoplesPharmacy/PharmFullText.cfm?ID=20666 & stor

ytype=HerbalMon

a

> I've been on MTX since Sept 03 and Enbrel added 6 wks ago.

> Because of elevated liver enzymes, and despite concurrent

> use of folic acid, leukovorin was added in January.

> Now, probably because I have little response to the drugs,

> my rheumy suggested that I take the leukovorin 24 hrs

> after the MTX injection. I'd been taking it at the same

> time but now he feels it may be inactivating it.

> Anyone heard of this before?

> I am eager to find some pain relief!

> Joanne

>

>

>

>

>

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Guest guest

I also

> took milk thistle.

> Milk Thistle , an herb, has a long history of being a liver

protector. SAMe

> also has been demonstrated

> to protect the liver from drug-induced damage.

Hi a,

I am about to start taking MTX. I was aware of milk thistle, and

asked my rheumy if I could take it along with the MTX. Because she

had never heard of it and didn't know what possible interactions

there might be, she discouraged me. Did your rheumy have any

knowledge of it or opinions about it?

Thanks.

Sierra

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Sierra,

Yes, my rheumy knew I was taking it. My suggestion is to print out articles

and bring them to him to read.

Ask him to research it and see what he thinks.

a

> Hi a,

> I am about to start taking MTX. I was aware of milk thistle, and

> asked my rheumy if I could take it along with the MTX. Because she

> had never heard of it and didn't know what possible interactions

> there might be, she discouraged me. Did your rheumy have any

> knowledge of it or opinions about it?

>

> Thanks.

> Sierra

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Guest guest

Thanks!

S.

> Sierra,

> Yes, my rheumy knew I was taking it. My suggestion is to print out

articles

> and bring them to him to read.

> Ask him to research it and see what he thinks.

> a

>

>

>

> > Hi a,

> > I am about to start taking MTX. I was aware of milk thistle, and

> > asked my rheumy if I could take it along with the MTX. Because she

> > had never heard of it and didn't know what possible interactions

> > there might be, she discouraged me. Did your rheumy have any

> > knowledge of it or opinions about it?

> >

> > Thanks.

> > Sierra

>

>

>

>

>

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