Intake of Dietary Flavonoids Inversely Associated with Marker of Inflammation

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Intake of Dietary Flavonoids Inversely Associated with Marker of

Inflammation

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Reference: " Serum C-Reactive Protein Concentrations Are Inversely

Associated with Dietary Flavonoid Intake in U.S. Adults, " Chun OK, Chung

SJ, et al, J Nutr, 2008; 138(4): 753-60. (Address: Won O. Song,

Department of Food Science and Human Nutrition, Michigan State

University, East Lansing, MI 48824, USA. E-mail: song@... ).

Summary: In a cross-sectional study involving data from 8,335 adults at

least 19 years of age, total flavonoid intake was found to be inversely

associated with serum C-reactive protein (CRP) concentration - a

biomarker for chronic inflammation and a sensitive risk factor for

cardiovascular diseases. Serum CRP concentrations were found to be

higher in women, older adults, blacks, smokers, those with high BMI or

low exercise level, and those taking non-steroidal anti-inflammatory

drugs (NSAIDs). After adjusting for covariates, intake of apples and

vegetables were inversely associated with serum CRP concentration. The

specific flavonoid compounds - quercetin, kaempferol, malvidin,

peonidin, daidzein, and genistein - were found to be inversely

associated with CRP concentration, even after adjusting for fruit and

vegetable consumption. The authors conclude, " Intake of flavonoid-rich

foods may thus reduce inflammation-mediated chronic diseases. "

--

ne Holden, MS, RD

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